Association between ratio of serum eicosapentaenoic acid to arachidonic acid and risk of cardiovascular disease

The Hisayama Study

Toshiharu Ninomiya, Masaharu Nagata, Jun Hata, Yoichiro Hirakawa, Mio Ozawa, Daigo Yoshida, Tomoyuki Ohara, Hiro Kishimoto, Naoko Mukai, Masayo Fukuhara, Takanari Kitazono, Yutaka Kiyohara

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Objective: We examined the association between the ratio of serum eicosapentaenoic acid to arachidonic acid (EPA/AA) or the docosahexaenoic acid (DHA)/AA and the development of cardiovascular disease in a general Japanese population. Methods: A total of 3103 community-dwelling Japanese individuals aged ≥40 years were followed up for an average of 5.1 years. Serum EPA/AA ratios were categorized into quartiles. The risk estimates were computed using a Cox proportional hazards model. Results: During the follow-up period, 127 subjects experienced cardiovascular events. Age- and sex-adjusted incidence rates of cardiovascular disease increased with lower serum EPA/AA ratios in individuals with high-sensitivity C-reactive protein (HS-CRP) of ≥1.0mg/L ( p for trend=0.006), whereas no clear association was observed in those with HS-CRP of <1.0mg/L (p for trend=0.27). The multivariable-adjusted risk of cardiovascular disease increased significantly, by 1.52 times (95% confidence interval 1.12-2.04) per 0.20 decrement in serum EPA/AA ratio in subjects with HS-CRP of ≥1.0mg/L. A lower serum EPA/AA ratio was significantly associated with an increased risk of coronary heart disease, but there was no evidence of an association with stroke. The magnitude of the influence of the serum EPA/AA ratio on the cardiovascular risk increased significantly with elevating HS-CRP levels taken as a continuous variable (p for heterogeneity=0.007). However, no such association was observed for DHA/AA ratio. Conclusion: Our findings suggest that a lower serum EPA/AA ratio is associated with a greater risk of cardiovascular disease, especially coronary heart disease, among subjects with higher HS-CRP levels in the general Japanese population.

Original languageEnglish
Pages (from-to)261-267
Number of pages7
JournalAtherosclerosis
Volume231
Issue number2
DOIs
Publication statusPublished - Dec 1 2013

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Eicosapentaenoic Acid
Arachidonic Acid
Cardiovascular Diseases
C-Reactive Protein
Serum
Docosahexaenoic Acids
Coronary Disease
Independent Living
Proportional Hazards Models
Population
Stroke
Confidence Intervals
Incidence

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Association between ratio of serum eicosapentaenoic acid to arachidonic acid and risk of cardiovascular disease : The Hisayama Study. / Ninomiya, Toshiharu; Nagata, Masaharu; Hata, Jun; Hirakawa, Yoichiro; Ozawa, Mio; Yoshida, Daigo; Ohara, Tomoyuki; Kishimoto, Hiro; Mukai, Naoko; Fukuhara, Masayo; Kitazono, Takanari; Kiyohara, Yutaka.

In: Atherosclerosis, Vol. 231, No. 2, 01.12.2013, p. 261-267.

Research output: Contribution to journalArticle

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abstract = "Objective: We examined the association between the ratio of serum eicosapentaenoic acid to arachidonic acid (EPA/AA) or the docosahexaenoic acid (DHA)/AA and the development of cardiovascular disease in a general Japanese population. Methods: A total of 3103 community-dwelling Japanese individuals aged ≥40 years were followed up for an average of 5.1 years. Serum EPA/AA ratios were categorized into quartiles. The risk estimates were computed using a Cox proportional hazards model. Results: During the follow-up period, 127 subjects experienced cardiovascular events. Age- and sex-adjusted incidence rates of cardiovascular disease increased with lower serum EPA/AA ratios in individuals with high-sensitivity C-reactive protein (HS-CRP) of ≥1.0mg/L ( p for trend=0.006), whereas no clear association was observed in those with HS-CRP of <1.0mg/L (p for trend=0.27). The multivariable-adjusted risk of cardiovascular disease increased significantly, by 1.52 times (95{\%} confidence interval 1.12-2.04) per 0.20 decrement in serum EPA/AA ratio in subjects with HS-CRP of ≥1.0mg/L. A lower serum EPA/AA ratio was significantly associated with an increased risk of coronary heart disease, but there was no evidence of an association with stroke. The magnitude of the influence of the serum EPA/AA ratio on the cardiovascular risk increased significantly with elevating HS-CRP levels taken as a continuous variable (p for heterogeneity=0.007). However, no such association was observed for DHA/AA ratio. Conclusion: Our findings suggest that a lower serum EPA/AA ratio is associated with a greater risk of cardiovascular disease, especially coronary heart disease, among subjects with higher HS-CRP levels in the general Japanese population.",
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AU - Ninomiya, Toshiharu

AU - Nagata, Masaharu

AU - Hata, Jun

AU - Hirakawa, Yoichiro

AU - Ozawa, Mio

AU - Yoshida, Daigo

AU - Ohara, Tomoyuki

AU - Kishimoto, Hiro

AU - Mukai, Naoko

AU - Fukuhara, Masayo

AU - Kitazono, Takanari

AU - Kiyohara, Yutaka

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