Abstract
Objective. The presence of regional lymph node metastasis is one of the prognostic factors for uterine cervical cancer. The development of metastasis requires that cancer cells avoid lymphocyte attack. Impaired lymphocyte function is mediated by apoptotic factors including receptor-binding cancer antigen expressed on SiSo cells (RCAS1), Fas ligand (FasL), and tumor necrosis factor-α (TNF-α). Our aim was to evaluate the association between expression of these factors and microenvironmental lymphocyte apoptosis in this disease. Methods. Immunohistochemical methods were used to determine the relationship between the expression of RCAS1, FasL, and TNF-α, and the number of apoptotic lymphocytes in primary lesions and metastatic lymph nodes in patients with cervical cancer. Results. Expression of these apoptosis-inducing molecules was quite different in primary tumors and metastatic lymph nodes: RCAS1 expression in lymph nodes was significantly higher than that in primary lesions (P < 0.0001), whereas FasL and TNF-α expressions at these two locations were not significantly different. The number of cells with positive expression of RCAS1, but not of FasL or TNF-α, was significantly correlated with the number of apoptotic lymphocytes in uterine cervix and metastatic lymph nodes (P < 0.0001 for both). Conclusion. RCAS1 expression may be related to tumor cell evasion of immune surveillance via induction of lymphocyte apoptosis in primary lesions and metastatic lymph nodes in uterine cervical cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 772-779 |
| Number of pages | 8 |
| Journal | Gynecologic Oncology |
| Volume | 97 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jun 1 2005 |
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All Science Journal Classification (ASJC) codes
- Oncology
- Obstetrics and Gynaecology
Cite this
Association between RCAS1 expression and microenvironmental immune cell death in uterine cervical cancer. / Sonoda, Kenzo; Miyamoto, Shingo; Hirakawa, Toshio; yagi, hiroshi; Yotsumoto, Fusanori; Nakashima, Manabu; Watanabe, Takeshi; Nakano, Hitoo.
In: Gynecologic Oncology, Vol. 97, No. 3, 01.06.2005, p. 772-779.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association between RCAS1 expression and microenvironmental immune cell death in uterine cervical cancer
AU - Sonoda, Kenzo
AU - Miyamoto, Shingo
AU - Hirakawa, Toshio
AU - yagi, hiroshi
AU - Yotsumoto, Fusanori
AU - Nakashima, Manabu
AU - Watanabe, Takeshi
AU - Nakano, Hitoo
PY - 2005/6/1
Y1 - 2005/6/1
N2 - Objective. The presence of regional lymph node metastasis is one of the prognostic factors for uterine cervical cancer. The development of metastasis requires that cancer cells avoid lymphocyte attack. Impaired lymphocyte function is mediated by apoptotic factors including receptor-binding cancer antigen expressed on SiSo cells (RCAS1), Fas ligand (FasL), and tumor necrosis factor-α (TNF-α). Our aim was to evaluate the association between expression of these factors and microenvironmental lymphocyte apoptosis in this disease. Methods. Immunohistochemical methods were used to determine the relationship between the expression of RCAS1, FasL, and TNF-α, and the number of apoptotic lymphocytes in primary lesions and metastatic lymph nodes in patients with cervical cancer. Results. Expression of these apoptosis-inducing molecules was quite different in primary tumors and metastatic lymph nodes: RCAS1 expression in lymph nodes was significantly higher than that in primary lesions (P < 0.0001), whereas FasL and TNF-α expressions at these two locations were not significantly different. The number of cells with positive expression of RCAS1, but not of FasL or TNF-α, was significantly correlated with the number of apoptotic lymphocytes in uterine cervix and metastatic lymph nodes (P < 0.0001 for both). Conclusion. RCAS1 expression may be related to tumor cell evasion of immune surveillance via induction of lymphocyte apoptosis in primary lesions and metastatic lymph nodes in uterine cervical cancer.
AB - Objective. The presence of regional lymph node metastasis is one of the prognostic factors for uterine cervical cancer. The development of metastasis requires that cancer cells avoid lymphocyte attack. Impaired lymphocyte function is mediated by apoptotic factors including receptor-binding cancer antigen expressed on SiSo cells (RCAS1), Fas ligand (FasL), and tumor necrosis factor-α (TNF-α). Our aim was to evaluate the association between expression of these factors and microenvironmental lymphocyte apoptosis in this disease. Methods. Immunohistochemical methods were used to determine the relationship between the expression of RCAS1, FasL, and TNF-α, and the number of apoptotic lymphocytes in primary lesions and metastatic lymph nodes in patients with cervical cancer. Results. Expression of these apoptosis-inducing molecules was quite different in primary tumors and metastatic lymph nodes: RCAS1 expression in lymph nodes was significantly higher than that in primary lesions (P < 0.0001), whereas FasL and TNF-α expressions at these two locations were not significantly different. The number of cells with positive expression of RCAS1, but not of FasL or TNF-α, was significantly correlated with the number of apoptotic lymphocytes in uterine cervix and metastatic lymph nodes (P < 0.0001 for both). Conclusion. RCAS1 expression may be related to tumor cell evasion of immune surveillance via induction of lymphocyte apoptosis in primary lesions and metastatic lymph nodes in uterine cervical cancer.
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UR - http://www.scopus.com/inward/citedby.url?scp=20444489510&partnerID=8YFLogxK
U2 - 10.1016/j.ygyno.2005.02.025
DO - 10.1016/j.ygyno.2005.02.025
M3 - Article
C2 - 15943986
AN - SCOPUS:20444489510
VL - 97
SP - 772
EP - 779
JO - Gynecologic Oncology
JF - Gynecologic Oncology
SN - 0090-8258
IS - 3
ER -