Association between RCAS1 expression and microenvironmental immune cell death in uterine cervical cancer

Kenzo Sonoda, Shingo Miyamoto, Toshio Hirakawa, hiroshi yagi, Fusanori Yotsumoto, Manabu Nakashima, Takeshi Watanabe, Hitoo Nakano

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Objective. The presence of regional lymph node metastasis is one of the prognostic factors for uterine cervical cancer. The development of metastasis requires that cancer cells avoid lymphocyte attack. Impaired lymphocyte function is mediated by apoptotic factors including receptor-binding cancer antigen expressed on SiSo cells (RCAS1), Fas ligand (FasL), and tumor necrosis factor-α (TNF-α). Our aim was to evaluate the association between expression of these factors and microenvironmental lymphocyte apoptosis in this disease. Methods. Immunohistochemical methods were used to determine the relationship between the expression of RCAS1, FasL, and TNF-α, and the number of apoptotic lymphocytes in primary lesions and metastatic lymph nodes in patients with cervical cancer. Results. Expression of these apoptosis-inducing molecules was quite different in primary tumors and metastatic lymph nodes: RCAS1 expression in lymph nodes was significantly higher than that in primary lesions (P < 0.0001), whereas FasL and TNF-α expressions at these two locations were not significantly different. The number of cells with positive expression of RCAS1, but not of FasL or TNF-α, was significantly correlated with the number of apoptotic lymphocytes in uterine cervix and metastatic lymph nodes (P < 0.0001 for both). Conclusion. RCAS1 expression may be related to tumor cell evasion of immune surveillance via induction of lymphocyte apoptosis in primary lesions and metastatic lymph nodes in uterine cervical cancer.

Original languageEnglish
Pages (from-to)772-779
Number of pages8
JournalGynecologic Oncology
Volume97
Issue number3
DOIs
Publication statusPublished - Jun 1 2005

Fingerprint

Uterine Cervical Neoplasms
Fas Ligand Protein
Cell Death
Lymph Nodes
Tumor Necrosis Factor-alpha
Lymphocytes
Lymphocyte Count
Apoptosis
Tumor Escape
Neoplasm Metastasis
Neoplasms
Cervix Uteri
Cell Count
Antigens

All Science Journal Classification (ASJC) codes

  • Oncology
  • Obstetrics and Gynaecology

Cite this

Association between RCAS1 expression and microenvironmental immune cell death in uterine cervical cancer. / Sonoda, Kenzo; Miyamoto, Shingo; Hirakawa, Toshio; yagi, hiroshi; Yotsumoto, Fusanori; Nakashima, Manabu; Watanabe, Takeshi; Nakano, Hitoo.

In: Gynecologic Oncology, Vol. 97, No. 3, 01.06.2005, p. 772-779.

Research output: Contribution to journalArticle

Sonoda, K, Miyamoto, S, Hirakawa, T, yagi, H, Yotsumoto, F, Nakashima, M, Watanabe, T & Nakano, H 2005, 'Association between RCAS1 expression and microenvironmental immune cell death in uterine cervical cancer', Gynecologic Oncology, vol. 97, no. 3, pp. 772-779. https://doi.org/10.1016/j.ygyno.2005.02.025
Sonoda, Kenzo ; Miyamoto, Shingo ; Hirakawa, Toshio ; yagi, hiroshi ; Yotsumoto, Fusanori ; Nakashima, Manabu ; Watanabe, Takeshi ; Nakano, Hitoo. / Association between RCAS1 expression and microenvironmental immune cell death in uterine cervical cancer. In: Gynecologic Oncology. 2005 ; Vol. 97, No. 3. pp. 772-779.
@article{440e7c9d39d44498a686b7bc06df2e3e,
title = "Association between RCAS1 expression and microenvironmental immune cell death in uterine cervical cancer",
abstract = "Objective. The presence of regional lymph node metastasis is one of the prognostic factors for uterine cervical cancer. The development of metastasis requires that cancer cells avoid lymphocyte attack. Impaired lymphocyte function is mediated by apoptotic factors including receptor-binding cancer antigen expressed on SiSo cells (RCAS1), Fas ligand (FasL), and tumor necrosis factor-α (TNF-α). Our aim was to evaluate the association between expression of these factors and microenvironmental lymphocyte apoptosis in this disease. Methods. Immunohistochemical methods were used to determine the relationship between the expression of RCAS1, FasL, and TNF-α, and the number of apoptotic lymphocytes in primary lesions and metastatic lymph nodes in patients with cervical cancer. Results. Expression of these apoptosis-inducing molecules was quite different in primary tumors and metastatic lymph nodes: RCAS1 expression in lymph nodes was significantly higher than that in primary lesions (P < 0.0001), whereas FasL and TNF-α expressions at these two locations were not significantly different. The number of cells with positive expression of RCAS1, but not of FasL or TNF-α, was significantly correlated with the number of apoptotic lymphocytes in uterine cervix and metastatic lymph nodes (P < 0.0001 for both). Conclusion. RCAS1 expression may be related to tumor cell evasion of immune surveillance via induction of lymphocyte apoptosis in primary lesions and metastatic lymph nodes in uterine cervical cancer.",
author = "Kenzo Sonoda and Shingo Miyamoto and Toshio Hirakawa and hiroshi yagi and Fusanori Yotsumoto and Manabu Nakashima and Takeshi Watanabe and Hitoo Nakano",
year = "2005",
month = "6",
day = "1",
doi = "10.1016/j.ygyno.2005.02.025",
language = "English",
volume = "97",
pages = "772--779",
journal = "Gynecologic Oncology",
issn = "0090-8258",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - Association between RCAS1 expression and microenvironmental immune cell death in uterine cervical cancer

AU - Sonoda, Kenzo

AU - Miyamoto, Shingo

AU - Hirakawa, Toshio

AU - yagi, hiroshi

AU - Yotsumoto, Fusanori

AU - Nakashima, Manabu

AU - Watanabe, Takeshi

AU - Nakano, Hitoo

PY - 2005/6/1

Y1 - 2005/6/1

N2 - Objective. The presence of regional lymph node metastasis is one of the prognostic factors for uterine cervical cancer. The development of metastasis requires that cancer cells avoid lymphocyte attack. Impaired lymphocyte function is mediated by apoptotic factors including receptor-binding cancer antigen expressed on SiSo cells (RCAS1), Fas ligand (FasL), and tumor necrosis factor-α (TNF-α). Our aim was to evaluate the association between expression of these factors and microenvironmental lymphocyte apoptosis in this disease. Methods. Immunohistochemical methods were used to determine the relationship between the expression of RCAS1, FasL, and TNF-α, and the number of apoptotic lymphocytes in primary lesions and metastatic lymph nodes in patients with cervical cancer. Results. Expression of these apoptosis-inducing molecules was quite different in primary tumors and metastatic lymph nodes: RCAS1 expression in lymph nodes was significantly higher than that in primary lesions (P < 0.0001), whereas FasL and TNF-α expressions at these two locations were not significantly different. The number of cells with positive expression of RCAS1, but not of FasL or TNF-α, was significantly correlated with the number of apoptotic lymphocytes in uterine cervix and metastatic lymph nodes (P < 0.0001 for both). Conclusion. RCAS1 expression may be related to tumor cell evasion of immune surveillance via induction of lymphocyte apoptosis in primary lesions and metastatic lymph nodes in uterine cervical cancer.

AB - Objective. The presence of regional lymph node metastasis is one of the prognostic factors for uterine cervical cancer. The development of metastasis requires that cancer cells avoid lymphocyte attack. Impaired lymphocyte function is mediated by apoptotic factors including receptor-binding cancer antigen expressed on SiSo cells (RCAS1), Fas ligand (FasL), and tumor necrosis factor-α (TNF-α). Our aim was to evaluate the association between expression of these factors and microenvironmental lymphocyte apoptosis in this disease. Methods. Immunohistochemical methods were used to determine the relationship between the expression of RCAS1, FasL, and TNF-α, and the number of apoptotic lymphocytes in primary lesions and metastatic lymph nodes in patients with cervical cancer. Results. Expression of these apoptosis-inducing molecules was quite different in primary tumors and metastatic lymph nodes: RCAS1 expression in lymph nodes was significantly higher than that in primary lesions (P < 0.0001), whereas FasL and TNF-α expressions at these two locations were not significantly different. The number of cells with positive expression of RCAS1, but not of FasL or TNF-α, was significantly correlated with the number of apoptotic lymphocytes in uterine cervix and metastatic lymph nodes (P < 0.0001 for both). Conclusion. RCAS1 expression may be related to tumor cell evasion of immune surveillance via induction of lymphocyte apoptosis in primary lesions and metastatic lymph nodes in uterine cervical cancer.

UR - http://www.scopus.com/inward/record.url?scp=20444489510&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20444489510&partnerID=8YFLogxK

U2 - 10.1016/j.ygyno.2005.02.025

DO - 10.1016/j.ygyno.2005.02.025

M3 - Article

C2 - 15943986

AN - SCOPUS:20444489510

VL - 97

SP - 772

EP - 779

JO - Gynecologic Oncology

JF - Gynecologic Oncology

SN - 0090-8258

IS - 3

ER -