Association between serum 25-hydroxyvitamin D and depressive symptoms in Japanese: Analysis by survey season

A. Nanri, T. Mizoue, Y. Matsushita, K. Poudel-Tandukar, M. Sato, M. Ohta, N. Mishima

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Both depressive symptoms and vitamin D insufficiency are common during winter. This study examined the association between serum 25-hydroxyvitamin D and depressive symptoms by survey season. Subjects were 527 municipal employees aged 21-67 years of two municipal offices in Japan. Overall, there was no measurable association. However, in the workplace surveyed in November, multivariate-adjusted odds ratios (95% confidence interval) of having depressive symptoms (Center for Epidemiologic Studies Depression score of 16) for the lowest through highest quartiles of serum 25-hydroxyvitamin D were 1.00 (reference), 0.84 (0.45-1.58), 0.83 (0.44-1.58) and 0.59 (0.30-1.15), respectively (trend P0.14). The association with the severe depressive state was more pronounced. By contrast, there was no such association in the workplace surveyed in July. Overall, this study did not provide evidence linking higher blood vitamin D levels with decreased depressive symptoms. The suggestive inverse association in sun-deprived season warrants further investigation.

Original languageEnglish
Pages (from-to)1444-1447
Number of pages4
JournalEuropean Journal of Clinical Nutrition
Volume63
Issue number12
DOIs
Publication statusPublished - Dec 26 2009

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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