Abstract
Serum albumin is the major intravascular antioxidant. Though oxidative stress plays an important role in the pathophysiology of Immunoglobulin A nephropathy (IgAN), the association between serum albumin and the progression of IgAN is not entirely understood. This retrospective cohort study of 1,352 participants with biopsy-proven IgAN determined the associations between serum albumin level and the incidence of end-stage renal disease (ESRD) using a Cox proportional hazards model. Patients were divided into three groups by tertiles of serum albumin level: Low, Middle, and High group (3.9 g/dL, 4.0–4.3 g/dL, 4.4 g/dL, respectively). During the median 5.1-year follow-up period, 152 patients (11.2%) developed ESRD. Participants in the Low group had a 1.88-fold increased risk for ESRD compared with those in the High group after adjustment for clinical parameters, including urinary protein excretion, and pathological parameters (Oxford classification). We also experimentally proved the antioxidant capacity of albumin on mesangial cells. The intracellular reactive oxygen species and mitochondrial injury, induced by hydrogen peroxide were significantly attenuated in albumin-pretreated mouse mesangial cells and human kidney cells compared with γ-globulin-pretreated cells. Low serum albumin level is an independent risk factor for ESRD in patients with IgAN. The mechanism could be explained by the antioxidant capacity of serum albumin.
| Original language | English |
|---|---|
| Article number | e0196655 |
| Journal | PloS one |
| Volume | 13 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 2018 |
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All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
- Agricultural and Biological Sciences(all)
Cite this
Association between serum albumin level and incidence of end-stage renal disease in patients with Immunoglobulin A nephropathy : A possible role of albumin as an antioxidant agent. / Kawai, Yasuhiro; Masutani, Kosuke; Torisu, Kumiko; Katafuchi, Ritsuko; Tanaka, Shigeru; Tsuchimoto, Akihiro; Mitsuiki, Koji; Tsuruya, Kazuhiko; Kitazono, Takanari.
In: PloS one, Vol. 13, No. 5, e0196655, 05.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association between serum albumin level and incidence of end-stage renal disease in patients with Immunoglobulin A nephropathy
T2 - A possible role of albumin as an antioxidant agent
AU - Kawai, Yasuhiro
AU - Masutani, Kosuke
AU - Torisu, Kumiko
AU - Katafuchi, Ritsuko
AU - Tanaka, Shigeru
AU - Tsuchimoto, Akihiro
AU - Mitsuiki, Koji
AU - Tsuruya, Kazuhiko
AU - Kitazono, Takanari
PY - 2018/5
Y1 - 2018/5
N2 - Serum albumin is the major intravascular antioxidant. Though oxidative stress plays an important role in the pathophysiology of Immunoglobulin A nephropathy (IgAN), the association between serum albumin and the progression of IgAN is not entirely understood. This retrospective cohort study of 1,352 participants with biopsy-proven IgAN determined the associations between serum albumin level and the incidence of end-stage renal disease (ESRD) using a Cox proportional hazards model. Patients were divided into three groups by tertiles of serum albumin level: Low, Middle, and High group (3.9 g/dL, 4.0–4.3 g/dL, 4.4 g/dL, respectively). During the median 5.1-year follow-up period, 152 patients (11.2%) developed ESRD. Participants in the Low group had a 1.88-fold increased risk for ESRD compared with those in the High group after adjustment for clinical parameters, including urinary protein excretion, and pathological parameters (Oxford classification). We also experimentally proved the antioxidant capacity of albumin on mesangial cells. The intracellular reactive oxygen species and mitochondrial injury, induced by hydrogen peroxide were significantly attenuated in albumin-pretreated mouse mesangial cells and human kidney cells compared with γ-globulin-pretreated cells. Low serum albumin level is an independent risk factor for ESRD in patients with IgAN. The mechanism could be explained by the antioxidant capacity of serum albumin.
AB - Serum albumin is the major intravascular antioxidant. Though oxidative stress plays an important role in the pathophysiology of Immunoglobulin A nephropathy (IgAN), the association between serum albumin and the progression of IgAN is not entirely understood. This retrospective cohort study of 1,352 participants with biopsy-proven IgAN determined the associations between serum albumin level and the incidence of end-stage renal disease (ESRD) using a Cox proportional hazards model. Patients were divided into three groups by tertiles of serum albumin level: Low, Middle, and High group (3.9 g/dL, 4.0–4.3 g/dL, 4.4 g/dL, respectively). During the median 5.1-year follow-up period, 152 patients (11.2%) developed ESRD. Participants in the Low group had a 1.88-fold increased risk for ESRD compared with those in the High group after adjustment for clinical parameters, including urinary protein excretion, and pathological parameters (Oxford classification). We also experimentally proved the antioxidant capacity of albumin on mesangial cells. The intracellular reactive oxygen species and mitochondrial injury, induced by hydrogen peroxide were significantly attenuated in albumin-pretreated mouse mesangial cells and human kidney cells compared with γ-globulin-pretreated cells. Low serum albumin level is an independent risk factor for ESRD in patients with IgAN. The mechanism could be explained by the antioxidant capacity of serum albumin.
UR - http://www.scopus.com/inward/record.url?scp=85047420425&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85047420425&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0196655
DO - 10.1371/journal.pone.0196655
M3 - Article
C2 - 29795559
AN - SCOPUS:85047420425
VL - 13
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 5
M1 - e0196655
ER -