Association between sleep duration and urinary albumin excretion in patients with type 2 diabetes: The Fukuoka Diabetes Registry

Toshiaki Ohkuma, Hiroki Fujii, Masanori Iwase, Shinako Ogata-Kaizu, Hitoshi Ide, Yohei Kikuchi, Yasuhiro Idewaki, Tamaki Jodai, Yoichiro Hirakawa, Udai Nakamura, Takanari Kitazono

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Objective: Few studies have so far investigated the impact of sleep duration on chronic kidney disease in diabetic patients. The objective of the present study was to examine the relationship between sleep duration and albuminuria in type 2 diabetic patients. Research Design and Methods: A total of 4,870 Japanese type 2 diabetic patients ≥20 years of age were divided into six groups according to self-reported sleep duration: less than 4.5 hours, 4.5-5.4 hours, 5.5-6.4 hours, 6.5-7.4 hours, 7.5-8.4 hours and more than 8.5 hours. The association between sleep duration and urinary albumin-creatinine ratio (UACR) was examined cross-sectionally. Results: Both short and long sleep durations were significantly associated with higher UACR levels and higher proportions of patients with albuminuria (≥30 mg/g) and macroalbuminuria (≥300 mg/g) compared with a sleep duration of 6.5-7.4 hours (P for quadratic trend <0.001). A U-shaped association between sleep duration and UACR remained significant even after adjustment for potential confounders, including age, sex, duration of diabetes, current smoking habits, former smoking habits, current drinking habits, regular exercise habits, total energy intake, total protein intake, hypnotic use and estimated glomerular filtration rate. Furthermore, the association remained substantially unchanged after additional adjustment for body mass index, hemoglobin A1c, systolic blood pressure, renin-angiotensin system inhibitor use and depressive symptoms. Conclusions: Our findings suggest that sleep duration has a U-shaped association with the UACR levels in type 2 diabetic patients, independent of potential confounders.

Original languageEnglish
Article numbere78968
JournalPloS one
Volume8
Issue number11
DOIs
Publication statusPublished - Nov 12 2013

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Medical problems
sleep
noninsulin-dependent diabetes mellitus
Type 2 Diabetes Mellitus
albumins
diabetes
Registries
Albumins
Sleep
excretion
duration
Habits
Creatinine
creatinine
Albuminuria
smoking (habit)
Smoking
Blood Pressure
renin-angiotensin system
Blood pressure

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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Association between sleep duration and urinary albumin excretion in patients with type 2 diabetes : The Fukuoka Diabetes Registry. / Ohkuma, Toshiaki; Fujii, Hiroki; Iwase, Masanori; Ogata-Kaizu, Shinako; Ide, Hitoshi; Kikuchi, Yohei; Idewaki, Yasuhiro; Jodai, Tamaki; Hirakawa, Yoichiro; Nakamura, Udai; Kitazono, Takanari.

In: PloS one, Vol. 8, No. 11, e78968, 12.11.2013.

Research output: Contribution to journalArticle

Ohkuma, Toshiaki ; Fujii, Hiroki ; Iwase, Masanori ; Ogata-Kaizu, Shinako ; Ide, Hitoshi ; Kikuchi, Yohei ; Idewaki, Yasuhiro ; Jodai, Tamaki ; Hirakawa, Yoichiro ; Nakamura, Udai ; Kitazono, Takanari. / Association between sleep duration and urinary albumin excretion in patients with type 2 diabetes : The Fukuoka Diabetes Registry. In: PloS one. 2013 ; Vol. 8, No. 11.
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