Association between the maximal distance of atrial septal protrusion and cryptogenic stroke

Keisuke Tokunaga, Masahiro Yasaka, Takahiro Kuwashiro, Seiji Gotoh, Asako Nakamura, Go Takaguchi, Tetsuro Ago, Masahiro Kamouchi, Takanari Kitazono, Yasushi Okada

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background and purpose: Previous studies have suggested that atrial septal aneurysm is a potential risk factor for cerebral embolism. However, the association between the level of atrial septal protrusion and cerebral embolism is still unclear. The purpose of the present study was to assess the association between the maximal distance of atrial septal protrusion and cryptogenic stroke. Methods: A total of 588 consecutive acute ischemic stroke patients (70±11 (mean±SD) years, 401 men) who underwent transesophageal echocardiography were enrolled. The maximal distance of atrial septal protrusion into the right or left atrium was measured. Atrial septal aneurysm was diagnosed when the maximal distance of atrial septal protrusion was >10 mm. Cryptogenic stroke was defined as non-lacunar ischemic stroke without >50% proximal artery stenosis or occlusion, cardioembolic sources, ≥4mm atherosclerotic plaques in the aortic arch, or carotid or vertebral artery dissection. Results: The rate of cryptogenic stroke increased with the increasing maximal distance of atrial septal protrusion. The maximal distance of atrial septal protrusion (multivariate-adjusted odds ratio (OR) per 1 mm, 1.14; 95% confidence interval (CI), 1.04–1.24; P=0.003) and atrial septal aneurysm (multivariate-adjusted OR, 4.32; 95% CI, 1.22–20.39; P=0.022) was independently associated with cryptogenic stroke. Conclusions: The maximal distance of atrial septal protrusion was independently associated with cryptogenic stroke.

Original languageEnglish
Pages (from-to)941-945
Number of pages5
JournalInternational Journal of Stroke
Volume12
Issue number9
DOIs
Publication statusPublished - Jan 1 2017

Fingerprint

Stroke
Aneurysm
Intracranial Embolism
Heart Atria
Odds Ratio
Vertebral Artery Dissection
Confidence Intervals
Transesophageal Echocardiography
Atherosclerotic Plaques
Thoracic Aorta
Carotid Arteries
Pathologic Constriction
Arteries

All Science Journal Classification (ASJC) codes

  • Neurology

Cite this

Tokunaga, K., Yasaka, M., Kuwashiro, T., Gotoh, S., Nakamura, A., Takaguchi, G., ... Okada, Y. (2017). Association between the maximal distance of atrial septal protrusion and cryptogenic stroke. International Journal of Stroke, 12(9), 941-945. https://doi.org/10.1177/1747493016685721

Association between the maximal distance of atrial septal protrusion and cryptogenic stroke. / Tokunaga, Keisuke; Yasaka, Masahiro; Kuwashiro, Takahiro; Gotoh, Seiji; Nakamura, Asako; Takaguchi, Go; Ago, Tetsuro; Kamouchi, Masahiro; Kitazono, Takanari; Okada, Yasushi.

In: International Journal of Stroke, Vol. 12, No. 9, 01.01.2017, p. 941-945.

Research output: Contribution to journalArticle

Tokunaga, Keisuke ; Yasaka, Masahiro ; Kuwashiro, Takahiro ; Gotoh, Seiji ; Nakamura, Asako ; Takaguchi, Go ; Ago, Tetsuro ; Kamouchi, Masahiro ; Kitazono, Takanari ; Okada, Yasushi. / Association between the maximal distance of atrial septal protrusion and cryptogenic stroke. In: International Journal of Stroke. 2017 ; Vol. 12, No. 9. pp. 941-945.
@article{30cd46211ffc46f1bd8e632e9a9a442d,
title = "Association between the maximal distance of atrial septal protrusion and cryptogenic stroke",
abstract = "Background and purpose: Previous studies have suggested that atrial septal aneurysm is a potential risk factor for cerebral embolism. However, the association between the level of atrial septal protrusion and cerebral embolism is still unclear. The purpose of the present study was to assess the association between the maximal distance of atrial septal protrusion and cryptogenic stroke. Methods: A total of 588 consecutive acute ischemic stroke patients (70±11 (mean±SD) years, 401 men) who underwent transesophageal echocardiography were enrolled. The maximal distance of atrial septal protrusion into the right or left atrium was measured. Atrial septal aneurysm was diagnosed when the maximal distance of atrial septal protrusion was >10 mm. Cryptogenic stroke was defined as non-lacunar ischemic stroke without >50{\%} proximal artery stenosis or occlusion, cardioembolic sources, ≥4mm atherosclerotic plaques in the aortic arch, or carotid or vertebral artery dissection. Results: The rate of cryptogenic stroke increased with the increasing maximal distance of atrial septal protrusion. The maximal distance of atrial septal protrusion (multivariate-adjusted odds ratio (OR) per 1 mm, 1.14; 95{\%} confidence interval (CI), 1.04–1.24; P=0.003) and atrial septal aneurysm (multivariate-adjusted OR, 4.32; 95{\%} CI, 1.22–20.39; P=0.022) was independently associated with cryptogenic stroke. Conclusions: The maximal distance of atrial septal protrusion was independently associated with cryptogenic stroke.",
author = "Keisuke Tokunaga and Masahiro Yasaka and Takahiro Kuwashiro and Seiji Gotoh and Asako Nakamura and Go Takaguchi and Tetsuro Ago and Masahiro Kamouchi and Takanari Kitazono and Yasushi Okada",
year = "2017",
month = "1",
day = "1",
doi = "10.1177/1747493016685721",
language = "English",
volume = "12",
pages = "941--945",
journal = "International Journal of Stroke",
issn = "1747-4930",
publisher = "Wiley-Blackwell",
number = "9",

}

TY - JOUR

T1 - Association between the maximal distance of atrial septal protrusion and cryptogenic stroke

AU - Tokunaga, Keisuke

AU - Yasaka, Masahiro

AU - Kuwashiro, Takahiro

AU - Gotoh, Seiji

AU - Nakamura, Asako

AU - Takaguchi, Go

AU - Ago, Tetsuro

AU - Kamouchi, Masahiro

AU - Kitazono, Takanari

AU - Okada, Yasushi

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Background and purpose: Previous studies have suggested that atrial septal aneurysm is a potential risk factor for cerebral embolism. However, the association between the level of atrial septal protrusion and cerebral embolism is still unclear. The purpose of the present study was to assess the association between the maximal distance of atrial septal protrusion and cryptogenic stroke. Methods: A total of 588 consecutive acute ischemic stroke patients (70±11 (mean±SD) years, 401 men) who underwent transesophageal echocardiography were enrolled. The maximal distance of atrial septal protrusion into the right or left atrium was measured. Atrial septal aneurysm was diagnosed when the maximal distance of atrial septal protrusion was >10 mm. Cryptogenic stroke was defined as non-lacunar ischemic stroke without >50% proximal artery stenosis or occlusion, cardioembolic sources, ≥4mm atherosclerotic plaques in the aortic arch, or carotid or vertebral artery dissection. Results: The rate of cryptogenic stroke increased with the increasing maximal distance of atrial septal protrusion. The maximal distance of atrial septal protrusion (multivariate-adjusted odds ratio (OR) per 1 mm, 1.14; 95% confidence interval (CI), 1.04–1.24; P=0.003) and atrial septal aneurysm (multivariate-adjusted OR, 4.32; 95% CI, 1.22–20.39; P=0.022) was independently associated with cryptogenic stroke. Conclusions: The maximal distance of atrial septal protrusion was independently associated with cryptogenic stroke.

AB - Background and purpose: Previous studies have suggested that atrial septal aneurysm is a potential risk factor for cerebral embolism. However, the association between the level of atrial septal protrusion and cerebral embolism is still unclear. The purpose of the present study was to assess the association between the maximal distance of atrial septal protrusion and cryptogenic stroke. Methods: A total of 588 consecutive acute ischemic stroke patients (70±11 (mean±SD) years, 401 men) who underwent transesophageal echocardiography were enrolled. The maximal distance of atrial septal protrusion into the right or left atrium was measured. Atrial septal aneurysm was diagnosed when the maximal distance of atrial septal protrusion was >10 mm. Cryptogenic stroke was defined as non-lacunar ischemic stroke without >50% proximal artery stenosis or occlusion, cardioembolic sources, ≥4mm atherosclerotic plaques in the aortic arch, or carotid or vertebral artery dissection. Results: The rate of cryptogenic stroke increased with the increasing maximal distance of atrial septal protrusion. The maximal distance of atrial septal protrusion (multivariate-adjusted odds ratio (OR) per 1 mm, 1.14; 95% confidence interval (CI), 1.04–1.24; P=0.003) and atrial septal aneurysm (multivariate-adjusted OR, 4.32; 95% CI, 1.22–20.39; P=0.022) was independently associated with cryptogenic stroke. Conclusions: The maximal distance of atrial septal protrusion was independently associated with cryptogenic stroke.

UR - http://www.scopus.com/inward/record.url?scp=85044041397&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85044041397&partnerID=8YFLogxK

U2 - 10.1177/1747493016685721

DO - 10.1177/1747493016685721

M3 - Article

C2 - 28885101

AN - SCOPUS:85044041397

VL - 12

SP - 941

EP - 945

JO - International Journal of Stroke

JF - International Journal of Stroke

SN - 1747-4930

IS - 9

ER -