TY - JOUR
T1 - Association between the melanopsin gene polymorphism OPN4*Ile394Thr and sleep/wake timing in Japanese university students
AU - Lee, Sang Il
AU - Hida, Akiko
AU - Kitamura, Shingo
AU - Mishima, Kazuo
AU - Higuchi, Shigekazu
N1 - Funding Information:
This study was supported in part by JSPS KAKENHI (24370102) and a part of this study is the result of ‘Understanding of Molecular and Environmental Bases for Brain Health’ carried out under the Strategic Research Program for Brain Sciences by the Ministry of Education, Culture, Sports, Science and Technology of Japan. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We would like to thank Takeshi Nishi at Kyushu University, Kaoru Inami at Fukuoka Women’s University and especially Mie Kato at National Center of Neurology and Psychiatry for technical assistance in genetic analysis.
Publisher Copyright:
© 2014 Lee et al.; licensee BioMed Central Ltd.
PY - 2014/6/12
Y1 - 2014/6/12
N2 - Background: In our previous studies, we found that the Ile394Thr SNP in the melanopsin gene (OPN4) was functionally associated with the pupillary light reflex. This indicates the possibility that OPN4*Ile394Thr is associated with other non-image forming responses. The aim of this study was therefore to determine whether OPN4*Ile394Thr is associated with sleep/wake timing. Methods: A total of 348 healthy Japanese university students participated in this study. Scalp hair was used to genotype the Ile394Thr SNP of OPN4. Sleep habits, including bedtime, wake time and sleep duration, were assessed separately for weekdays and weekends. A total of 328 samples, including 223 samples with TT genotype, 91 with TC genotype and 14 with CC genotype, were used for statistical analysis. No significant difference in age or male/ female distribution was found among the three genotype groups. Results: There was no significant difference in circadian preference among the genotype groups. During weekdays, bedtime, wake time and midpoint of sleep for CC subjects were significantly later than those for TT and TC subjects. However, there was no difference between TT and TC subjects in any of their sleep habits. During weekends, bedtime of CC subjects was significantly later than those of TT and TC subjects, and the midpoint of sleep of CC subjects was significantly later than that of TC subjects. Conclusions: Our findings demonstrated that OPN4*Ile394Thr is associated with sleep/wake timing. We also found that the sleep/wake timing of subjects with the CC genotype was later than that of subjects with the TT or TC genotype.
AB - Background: In our previous studies, we found that the Ile394Thr SNP in the melanopsin gene (OPN4) was functionally associated with the pupillary light reflex. This indicates the possibility that OPN4*Ile394Thr is associated with other non-image forming responses. The aim of this study was therefore to determine whether OPN4*Ile394Thr is associated with sleep/wake timing. Methods: A total of 348 healthy Japanese university students participated in this study. Scalp hair was used to genotype the Ile394Thr SNP of OPN4. Sleep habits, including bedtime, wake time and sleep duration, were assessed separately for weekdays and weekends. A total of 328 samples, including 223 samples with TT genotype, 91 with TC genotype and 14 with CC genotype, were used for statistical analysis. No significant difference in age or male/ female distribution was found among the three genotype groups. Results: There was no significant difference in circadian preference among the genotype groups. During weekdays, bedtime, wake time and midpoint of sleep for CC subjects were significantly later than those for TT and TC subjects. However, there was no difference between TT and TC subjects in any of their sleep habits. During weekends, bedtime of CC subjects was significantly later than those of TT and TC subjects, and the midpoint of sleep of CC subjects was significantly later than that of TC subjects. Conclusions: Our findings demonstrated that OPN4*Ile394Thr is associated with sleep/wake timing. We also found that the sleep/wake timing of subjects with the CC genotype was later than that of subjects with the TT or TC genotype.
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U2 - 10.1186/1880-6805-33-9
DO - 10.1186/1880-6805-33-9
M3 - Article
C2 - 24887407
AN - SCOPUS:84910009870
VL - 33
JO - Journal of Physiological Anthropology
JF - Journal of Physiological Anthropology
SN - 1880-6791
IS - 1
M1 - 9
ER -
