Association between white blood cell count and diabetes in relation to triglycerides-to-hdl cholesterol ratio in a japanese population: The nagasaki islands study

Yuji Shimizu, Mio Nakazat, Koichiro Kadota, Shimpei Sato, Jun Koyam Atsu, Kazuhiko Arima, Hironori Yamasaki, Noboru Takamura, Kiyoshi Aoyagi, Takahiro Maeda

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Abstract

Although our previous study found that diabetes combined with a high serum triglycerides to high-density lipoprotein cholesterol (TG-HDL) ratio constitutes a risk for atherosclerosis and chronic kidney disease (CKD), the association, in terms of TG-HDL ratio, between diabetes and white blood cell (WBC) count, which is an independent risk factor for atherosclerosis, has not been clarifed. To investigate this association, we conducted a cross-sectional study of 3,998 Japanese subjects aged 30-89 years undergoing a general health check. We investigated the associations between WBC count and diabetes for all subjects, who were divided into tertiles according to TG-HDL level. Independent of classical cardiovascular risk factors, WBC count of both men and women was positively associated with diabetes combined with high but not with low TG-HDL. The multivariable odds ratios (ORs) and 95% confdence intervals (95%CIs) of 1SD (standard deviation) increment in WBC count (1,538/μL for men, 1,382/μL for women) for high TG-HDL diabetes and low TG-HDL diabetes were 1.39 (95%CI: 1.04-1.85) and 0.88 (95%CI: 0.66-1.19) for men, and 1.83 (95%CI: 1.45-2.33) and 0.91 (95%CI: 0.64-1.29) for women, respectively. In conclusion, for both men and women, WBC count is associated with high TG-HDL diabetes but not with low TG-HDL diabetes. These fndings suggest that measuring WBC count is clinically relevant for estimating the risk of atherosclerosis and CKD in patients with diabetes categorized according to TG-HDL ratio.

Original languageEnglish
Pages (from-to)91-97
Number of pages7
JournalActa Medica Nagasakiensia
Volume59
Issue number3
Publication statusPublished - Jan 1 2015

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Leukocyte Count
Islands
HDL Cholesterol
Triglycerides
Cholesterol
Population
Atherosclerosis
Chronic Renal Insufficiency
Cross-Sectional Studies
Odds Ratio
Health
Serum

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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Association between white blood cell count and diabetes in relation to triglycerides-to-hdl cholesterol ratio in a japanese population : The nagasaki islands study. / Shimizu, Yuji; Nakazat, Mio; Kadota, Koichiro; Sato, Shimpei; Atsu, Jun Koyam; Arima, Kazuhiko; Yamasaki, Hironori; Takamura, Noboru; Aoyagi, Kiyoshi; Maeda, Takahiro.

In: Acta Medica Nagasakiensia, Vol. 59, No. 3, 01.01.2015, p. 91-97.

Research output: Contribution to journalArticle

Shimizu, Y, Nakazat, M, Kadota, K, Sato, S, Atsu, JK, Arima, K, Yamasaki, H, Takamura, N, Aoyagi, K & Maeda, T 2015, 'Association between white blood cell count and diabetes in relation to triglycerides-to-hdl cholesterol ratio in a japanese population: The nagasaki islands study', Acta Medica Nagasakiensia, vol. 59, no. 3, pp. 91-97.
Shimizu, Yuji ; Nakazat, Mio ; Kadota, Koichiro ; Sato, Shimpei ; Atsu, Jun Koyam ; Arima, Kazuhiko ; Yamasaki, Hironori ; Takamura, Noboru ; Aoyagi, Kiyoshi ; Maeda, Takahiro. / Association between white blood cell count and diabetes in relation to triglycerides-to-hdl cholesterol ratio in a japanese population : The nagasaki islands study. In: Acta Medica Nagasakiensia. 2015 ; Vol. 59, No. 3. pp. 91-97.
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