Association of b-type natriuretic peptide level with residual kidney function in incident peritoneal dialysis patients

Yasuhiro Kawai, Shigeru Tanaka, Hisako Yoshida, Masatoshi Hara, Hiroaki Tsujikawa, Kazuhiko Tsuruya, Takanari Kitazono

Research output: Contribution to journalArticle

Abstract

Background: Residual kidney function (RKF) is an important factor influencing both technique and patient survival in peritoneal dialysis (PD) patients. B-type natriuretic peptide (BNP) is considered a marker of cardio-renal syndrome. The relationship between BNP and RKF in PD patients remains unclear. Methods: We conducted a prospective study of 89 patients who had started and continued PD for 6 months or more in Kyushu University Hospital between June 2006 and September 2015. Participants were divided into low BNP (≤ 102.1 ng/L) and high BNP (>102.1ng/L) groups according to median plasma BNP level at PD initiation. The primary outcome was RKF loss, defined as 24-hour urine volume less than 100 mL. We estimated the association between BNP and RKF loss using a Kaplan-Meier method and Cox proportional hazards model and compared the rate of RKF decline between the 2 groups. To evaluate the consistency of the association, we performed subgroup analysis stratified by baseline characteristics. Results: During the median follow-up of 30 months, 30 patients lost RKF. Participants in the high BNP group had a 5.87-fold increased risk for RKF loss compared with the low BNP group after adjustment for clinical and cardiac parameters. A high plasma BNP level was more clearly associated with RKF loss in younger participants compared with older participants in subgroup analysis. Conclusions: B-type natriuretic peptide may be a useful risk marker for RKF loss in PD patients. The clinical importance of plasma BNP level as a marker of RKF loss might be affected by age.

Original languageEnglish
Pages (from-to)147-154
Number of pages8
JournalPeritoneal Dialysis International
Volume39
Issue number2
DOIs
Publication statusPublished - Mar 1 2019

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Natriuretic Peptides
Brain Natriuretic Peptide
Peritoneal Dialysis
Kidney
Cardio-Renal Syndrome
Proportional Hazards Models
Urine
Prospective Studies

All Science Journal Classification (ASJC) codes

  • Nephrology

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Association of b-type natriuretic peptide level with residual kidney function in incident peritoneal dialysis patients. / Kawai, Yasuhiro; Tanaka, Shigeru; Yoshida, Hisako; Hara, Masatoshi; Tsujikawa, Hiroaki; Tsuruya, Kazuhiko; Kitazono, Takanari.

In: Peritoneal Dialysis International, Vol. 39, No. 2, 01.03.2019, p. 147-154.

Research output: Contribution to journalArticle

Kawai, Yasuhiro ; Tanaka, Shigeru ; Yoshida, Hisako ; Hara, Masatoshi ; Tsujikawa, Hiroaki ; Tsuruya, Kazuhiko ; Kitazono, Takanari. / Association of b-type natriuretic peptide level with residual kidney function in incident peritoneal dialysis patients. In: Peritoneal Dialysis International. 2019 ; Vol. 39, No. 2. pp. 147-154.
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