Association of cognitive impairment with magnetic resonance imaging findings and social activities in patients with multiple sclerosis

Masaaki Niino, Nobuhiro Mifune, Tatsuo Kohriyama, Masahiro Mori, Takashi Ohashi, Izumi Kawachi, Yuko Shimizu, Hikoaki Fukaura, Ichiro Nakashima, Susumu Kusunoki, Katsuichi Miyamoto, Kazuto Yoshida, Takashi Kanda, Kyoichi Nomura, Takashi Yamamura, Fumihito Yoshii, Jun-Ichi Kira, Shunya Nakane, Kazumasa Yokoyama, Makoto MatsuiYusei Miyazaki, Seiji Kikuchi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective The aim of the present study was to investigate the association of magnetic resonance imaging (MRI) findings and social activity with cognitive function in Japanese patients with multiple sclerosis (MS).

Methods The Brief Repeatable Battery of Neuropsychological tests (BRB-N) was carried out in 184 Japanese patients with MS, and 163 controls matched for age, sex and education. MRI findings of cerebral, brainstem, and cerebellar lesions and social activities of MS patients were further examined.

Results MS patients with higher numbers of cerebral lesions on MRI had lower scores in most BRB-N tests. BRB-N scores in the majority of tests were significantly lower in patients with brainstem and cerebellar lesions. Data from an analysis of variance model in which only the main effects of cerebral, brainstem and cerebellar lesions were hypothesized showed an association of cerebral lesions with decreased scores in all BRB-N tests, except symbol digit modalities test (SDMT) and paced auditory serial addition test (PASAT). In contrast, cerebellar lesions were associated with decreased SDMT and PASAT scores. Patients categorized as "unemployed because of MS" had lower BRB-N scores than other social activity groups. Lower SDMT scores had an effect on the "unemployed because of MS" group, whereas the Expanded Disability Status Scale had a significantly greater negative impact on patients in this social category.

Conclusions Higher numbers of brain lesions on MRI could have an impact on cognitive function in patients with MS, and impairment of information processing appears significantly associated with cerebellar lesions. Cognitive impairment affects the employment status of patients with MS.

Original languageEnglish
Pages (from-to)328-335
Number of pages8
JournalClinical and Experimental Neuroimmunology
Volume5
Issue number3
DOIs
Publication statusPublished - Oct 1 2014

Fingerprint

Multiple Sclerosis
Magnetic Resonance Imaging
Neuropsychological Tests
Brain Stem
Cognition
Cognitive Dysfunction
Sex Education
Automatic Data Processing
Analysis of Variance
Brain

All Science Journal Classification (ASJC) codes

  • Neuroscience (miscellaneous)
  • Immunology
  • Immunology and Microbiology (miscellaneous)
  • Clinical Neurology

Cite this

Association of cognitive impairment with magnetic resonance imaging findings and social activities in patients with multiple sclerosis. / Niino, Masaaki; Mifune, Nobuhiro; Kohriyama, Tatsuo; Mori, Masahiro; Ohashi, Takashi; Kawachi, Izumi; Shimizu, Yuko; Fukaura, Hikoaki; Nakashima, Ichiro; Kusunoki, Susumu; Miyamoto, Katsuichi; Yoshida, Kazuto; Kanda, Takashi; Nomura, Kyoichi; Yamamura, Takashi; Yoshii, Fumihito; Kira, Jun-Ichi; Nakane, Shunya; Yokoyama, Kazumasa; Matsui, Makoto; Miyazaki, Yusei; Kikuchi, Seiji.

In: Clinical and Experimental Neuroimmunology, Vol. 5, No. 3, 01.10.2014, p. 328-335.

Research output: Contribution to journalArticle

Niino, M, Mifune, N, Kohriyama, T, Mori, M, Ohashi, T, Kawachi, I, Shimizu, Y, Fukaura, H, Nakashima, I, Kusunoki, S, Miyamoto, K, Yoshida, K, Kanda, T, Nomura, K, Yamamura, T, Yoshii, F, Kira, J-I, Nakane, S, Yokoyama, K, Matsui, M, Miyazaki, Y & Kikuchi, S 2014, 'Association of cognitive impairment with magnetic resonance imaging findings and social activities in patients with multiple sclerosis', Clinical and Experimental Neuroimmunology, vol. 5, no. 3, pp. 328-335. https://doi.org/10.1111/cen3.12133
Niino, Masaaki ; Mifune, Nobuhiro ; Kohriyama, Tatsuo ; Mori, Masahiro ; Ohashi, Takashi ; Kawachi, Izumi ; Shimizu, Yuko ; Fukaura, Hikoaki ; Nakashima, Ichiro ; Kusunoki, Susumu ; Miyamoto, Katsuichi ; Yoshida, Kazuto ; Kanda, Takashi ; Nomura, Kyoichi ; Yamamura, Takashi ; Yoshii, Fumihito ; Kira, Jun-Ichi ; Nakane, Shunya ; Yokoyama, Kazumasa ; Matsui, Makoto ; Miyazaki, Yusei ; Kikuchi, Seiji. / Association of cognitive impairment with magnetic resonance imaging findings and social activities in patients with multiple sclerosis. In: Clinical and Experimental Neuroimmunology. 2014 ; Vol. 5, No. 3. pp. 328-335.
@article{a8e2593f225444f7bcae204c837d4fad,
title = "Association of cognitive impairment with magnetic resonance imaging findings and social activities in patients with multiple sclerosis",
abstract = "Objective The aim of the present study was to investigate the association of magnetic resonance imaging (MRI) findings and social activity with cognitive function in Japanese patients with multiple sclerosis (MS).Methods The Brief Repeatable Battery of Neuropsychological tests (BRB-N) was carried out in 184 Japanese patients with MS, and 163 controls matched for age, sex and education. MRI findings of cerebral, brainstem, and cerebellar lesions and social activities of MS patients were further examined.Results MS patients with higher numbers of cerebral lesions on MRI had lower scores in most BRB-N tests. BRB-N scores in the majority of tests were significantly lower in patients with brainstem and cerebellar lesions. Data from an analysis of variance model in which only the main effects of cerebral, brainstem and cerebellar lesions were hypothesized showed an association of cerebral lesions with decreased scores in all BRB-N tests, except symbol digit modalities test (SDMT) and paced auditory serial addition test (PASAT). In contrast, cerebellar lesions were associated with decreased SDMT and PASAT scores. Patients categorized as {"}unemployed because of MS{"} had lower BRB-N scores than other social activity groups. Lower SDMT scores had an effect on the {"}unemployed because of MS{"} group, whereas the Expanded Disability Status Scale had a significantly greater negative impact on patients in this social category.Conclusions Higher numbers of brain lesions on MRI could have an impact on cognitive function in patients with MS, and impairment of information processing appears significantly associated with cerebellar lesions. Cognitive impairment affects the employment status of patients with MS.",
author = "Masaaki Niino and Nobuhiro Mifune and Tatsuo Kohriyama and Masahiro Mori and Takashi Ohashi and Izumi Kawachi and Yuko Shimizu and Hikoaki Fukaura and Ichiro Nakashima and Susumu Kusunoki and Katsuichi Miyamoto and Kazuto Yoshida and Takashi Kanda and Kyoichi Nomura and Takashi Yamamura and Fumihito Yoshii and Jun-Ichi Kira and Shunya Nakane and Kazumasa Yokoyama and Makoto Matsui and Yusei Miyazaki and Seiji Kikuchi",
year = "2014",
month = "10",
day = "1",
doi = "10.1111/cen3.12133",
language = "English",
volume = "5",
pages = "328--335",
journal = "Clinical and Experimental Neuroimmunology",
issn = "1759-1961",
publisher = "John Wiley and Sons Ltd",
number = "3",

}

TY - JOUR

T1 - Association of cognitive impairment with magnetic resonance imaging findings and social activities in patients with multiple sclerosis

AU - Niino, Masaaki

AU - Mifune, Nobuhiro

AU - Kohriyama, Tatsuo

AU - Mori, Masahiro

AU - Ohashi, Takashi

AU - Kawachi, Izumi

AU - Shimizu, Yuko

AU - Fukaura, Hikoaki

AU - Nakashima, Ichiro

AU - Kusunoki, Susumu

AU - Miyamoto, Katsuichi

AU - Yoshida, Kazuto

AU - Kanda, Takashi

AU - Nomura, Kyoichi

AU - Yamamura, Takashi

AU - Yoshii, Fumihito

AU - Kira, Jun-Ichi

AU - Nakane, Shunya

AU - Yokoyama, Kazumasa

AU - Matsui, Makoto

AU - Miyazaki, Yusei

AU - Kikuchi, Seiji

PY - 2014/10/1

Y1 - 2014/10/1

N2 - Objective The aim of the present study was to investigate the association of magnetic resonance imaging (MRI) findings and social activity with cognitive function in Japanese patients with multiple sclerosis (MS).Methods The Brief Repeatable Battery of Neuropsychological tests (BRB-N) was carried out in 184 Japanese patients with MS, and 163 controls matched for age, sex and education. MRI findings of cerebral, brainstem, and cerebellar lesions and social activities of MS patients were further examined.Results MS patients with higher numbers of cerebral lesions on MRI had lower scores in most BRB-N tests. BRB-N scores in the majority of tests were significantly lower in patients with brainstem and cerebellar lesions. Data from an analysis of variance model in which only the main effects of cerebral, brainstem and cerebellar lesions were hypothesized showed an association of cerebral lesions with decreased scores in all BRB-N tests, except symbol digit modalities test (SDMT) and paced auditory serial addition test (PASAT). In contrast, cerebellar lesions were associated with decreased SDMT and PASAT scores. Patients categorized as "unemployed because of MS" had lower BRB-N scores than other social activity groups. Lower SDMT scores had an effect on the "unemployed because of MS" group, whereas the Expanded Disability Status Scale had a significantly greater negative impact on patients in this social category.Conclusions Higher numbers of brain lesions on MRI could have an impact on cognitive function in patients with MS, and impairment of information processing appears significantly associated with cerebellar lesions. Cognitive impairment affects the employment status of patients with MS.

AB - Objective The aim of the present study was to investigate the association of magnetic resonance imaging (MRI) findings and social activity with cognitive function in Japanese patients with multiple sclerosis (MS).Methods The Brief Repeatable Battery of Neuropsychological tests (BRB-N) was carried out in 184 Japanese patients with MS, and 163 controls matched for age, sex and education. MRI findings of cerebral, brainstem, and cerebellar lesions and social activities of MS patients were further examined.Results MS patients with higher numbers of cerebral lesions on MRI had lower scores in most BRB-N tests. BRB-N scores in the majority of tests were significantly lower in patients with brainstem and cerebellar lesions. Data from an analysis of variance model in which only the main effects of cerebral, brainstem and cerebellar lesions were hypothesized showed an association of cerebral lesions with decreased scores in all BRB-N tests, except symbol digit modalities test (SDMT) and paced auditory serial addition test (PASAT). In contrast, cerebellar lesions were associated with decreased SDMT and PASAT scores. Patients categorized as "unemployed because of MS" had lower BRB-N scores than other social activity groups. Lower SDMT scores had an effect on the "unemployed because of MS" group, whereas the Expanded Disability Status Scale had a significantly greater negative impact on patients in this social category.Conclusions Higher numbers of brain lesions on MRI could have an impact on cognitive function in patients with MS, and impairment of information processing appears significantly associated with cerebellar lesions. Cognitive impairment affects the employment status of patients with MS.

UR - http://www.scopus.com/inward/record.url?scp=84908207743&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84908207743&partnerID=8YFLogxK

U2 - 10.1111/cen3.12133

DO - 10.1111/cen3.12133

M3 - Article

AN - SCOPUS:84908207743

VL - 5

SP - 328

EP - 335

JO - Clinical and Experimental Neuroimmunology

JF - Clinical and Experimental Neuroimmunology

SN - 1759-1961

IS - 3

ER -