Association of diabetic retinopathy with both sarcopenia and muscle quality in patients with type 2 diabetes: A crosssectional study

Tatsuya Fukuda, Ryotaro Bouchi, Takato Takeuchi, Yujiro Nakano, Masanori Murakami, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto, Yoshihiro Ogawa

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective To examine whether the existence and severity of diabetic retinopathy (DR) could be associated with the prevalent sarcopenia and muscle quality in patients with type 2 diabetes. Research design and methods This is a cross-sectional study of 316 patients with type 2 diabetes (mean age 65±12 years; 38% female). Body compositions were measured by the dual-energy X-ray absorptiometry. Patients were divided into three groups: patients without DR (NDR), with non-proliferative DR (NPDR) and proliferative DR (PDR). Sarcopenia was diagnosed according to the criteria for Asians, using both skeletal muscle index (SMI) and grip strength (kg). Muscle quality was also determined by the grip strength divided by SMI. Logistic regression analyses were carried out to assess the cross-sectional association of the severity of DR with sarcopenia. In addition, linear regression analyses were performed to determine the associations between DR and muscle quality. Selection of covariates in the multivariate logistic and linear regression analyses was done by a stepwise procedure. Results Among the patients examined, NDR, NPDR and PDR were diagnosed in 261, 38 and 17 patients, respectively. The prevalence of sarcopenia significantly increased along with the progression of DR. Multivariate logistic regression analysis showed that PDR is significantly associated with sarcopenia (OR 7.78, 95% CI 1.52 to 39.81, p=0.014) and low muscle strength (OR 6.25, 95% CI 1.15 to 33.96, p=0.034). Multivariate linear regression analysis additionally showed that the existence of DR was significantly associated with the muscle quality (standardized β −0.136, p=0.005 for NPDR, standardized β −0.146, p=0.003 for PDR). Conclusions This study provides evidence that PDR is significantly associated with sarcopenia, and the existence of DR increases the risk for low muscle quality in patients with type 2 diabetes.

Original languageEnglish
Article numbere000404
JournalBMJ Open Diabetes Research and Care
Volume5
Issue number1
DOIs
Publication statusPublished - May 1 2017

Fingerprint

Sarcopenia
Diabetic Retinopathy
Type 2 Diabetes Mellitus
Muscles
Regression Analysis
Linear Models
Logistic Models
Hand Strength
Skeletal Muscle
Photon Absorptiometry
Muscle Strength
Body Composition
Research Design
Cross-Sectional Studies

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism

Cite this

Association of diabetic retinopathy with both sarcopenia and muscle quality in patients with type 2 diabetes : A crosssectional study. / Fukuda, Tatsuya; Bouchi, Ryotaro; Takeuchi, Takato; Nakano, Yujiro; Murakami, Masanori; Minami, Isao; Izumiyama, Hajime; Hashimoto, Koshi; Yoshimoto, Takanobu; Ogawa, Yoshihiro.

In: BMJ Open Diabetes Research and Care, Vol. 5, No. 1, e000404, 01.05.2017.

Research output: Contribution to journalArticle

Fukuda, T, Bouchi, R, Takeuchi, T, Nakano, Y, Murakami, M, Minami, I, Izumiyama, H, Hashimoto, K, Yoshimoto, T & Ogawa, Y 2017, 'Association of diabetic retinopathy with both sarcopenia and muscle quality in patients with type 2 diabetes: A crosssectional study', BMJ Open Diabetes Research and Care, vol. 5, no. 1, e000404. https://doi.org/10.1136/bmjdrc-2017-000404
Fukuda, Tatsuya ; Bouchi, Ryotaro ; Takeuchi, Takato ; Nakano, Yujiro ; Murakami, Masanori ; Minami, Isao ; Izumiyama, Hajime ; Hashimoto, Koshi ; Yoshimoto, Takanobu ; Ogawa, Yoshihiro. / Association of diabetic retinopathy with both sarcopenia and muscle quality in patients with type 2 diabetes : A crosssectional study. In: BMJ Open Diabetes Research and Care. 2017 ; Vol. 5, No. 1.
@article{19d11e8b044e47569d3b4e0bf678f504,
title = "Association of diabetic retinopathy with both sarcopenia and muscle quality in patients with type 2 diabetes: A crosssectional study",
abstract = "Objective To examine whether the existence and severity of diabetic retinopathy (DR) could be associated with the prevalent sarcopenia and muscle quality in patients with type 2 diabetes. Research design and methods This is a cross-sectional study of 316 patients with type 2 diabetes (mean age 65±12 years; 38{\%} female). Body compositions were measured by the dual-energy X-ray absorptiometry. Patients were divided into three groups: patients without DR (NDR), with non-proliferative DR (NPDR) and proliferative DR (PDR). Sarcopenia was diagnosed according to the criteria for Asians, using both skeletal muscle index (SMI) and grip strength (kg). Muscle quality was also determined by the grip strength divided by SMI. Logistic regression analyses were carried out to assess the cross-sectional association of the severity of DR with sarcopenia. In addition, linear regression analyses were performed to determine the associations between DR and muscle quality. Selection of covariates in the multivariate logistic and linear regression analyses was done by a stepwise procedure. Results Among the patients examined, NDR, NPDR and PDR were diagnosed in 261, 38 and 17 patients, respectively. The prevalence of sarcopenia significantly increased along with the progression of DR. Multivariate logistic regression analysis showed that PDR is significantly associated with sarcopenia (OR 7.78, 95{\%} CI 1.52 to 39.81, p=0.014) and low muscle strength (OR 6.25, 95{\%} CI 1.15 to 33.96, p=0.034). Multivariate linear regression analysis additionally showed that the existence of DR was significantly associated with the muscle quality (standardized β −0.136, p=0.005 for NPDR, standardized β −0.146, p=0.003 for PDR). Conclusions This study provides evidence that PDR is significantly associated with sarcopenia, and the existence of DR increases the risk for low muscle quality in patients with type 2 diabetes.",
author = "Tatsuya Fukuda and Ryotaro Bouchi and Takato Takeuchi and Yujiro Nakano and Masanori Murakami and Isao Minami and Hajime Izumiyama and Koshi Hashimoto and Takanobu Yoshimoto and Yoshihiro Ogawa",
year = "2017",
month = "5",
day = "1",
doi = "10.1136/bmjdrc-2017-000404",
language = "English",
volume = "5",
journal = "BMJ Open Diabetes Research and Care",
issn = "2052-4897",
publisher = "BMJ Publishing Group",
number = "1",

}

TY - JOUR

T1 - Association of diabetic retinopathy with both sarcopenia and muscle quality in patients with type 2 diabetes

T2 - A crosssectional study

AU - Fukuda, Tatsuya

AU - Bouchi, Ryotaro

AU - Takeuchi, Takato

AU - Nakano, Yujiro

AU - Murakami, Masanori

AU - Minami, Isao

AU - Izumiyama, Hajime

AU - Hashimoto, Koshi

AU - Yoshimoto, Takanobu

AU - Ogawa, Yoshihiro

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Objective To examine whether the existence and severity of diabetic retinopathy (DR) could be associated with the prevalent sarcopenia and muscle quality in patients with type 2 diabetes. Research design and methods This is a cross-sectional study of 316 patients with type 2 diabetes (mean age 65±12 years; 38% female). Body compositions were measured by the dual-energy X-ray absorptiometry. Patients were divided into three groups: patients without DR (NDR), with non-proliferative DR (NPDR) and proliferative DR (PDR). Sarcopenia was diagnosed according to the criteria for Asians, using both skeletal muscle index (SMI) and grip strength (kg). Muscle quality was also determined by the grip strength divided by SMI. Logistic regression analyses were carried out to assess the cross-sectional association of the severity of DR with sarcopenia. In addition, linear regression analyses were performed to determine the associations between DR and muscle quality. Selection of covariates in the multivariate logistic and linear regression analyses was done by a stepwise procedure. Results Among the patients examined, NDR, NPDR and PDR were diagnosed in 261, 38 and 17 patients, respectively. The prevalence of sarcopenia significantly increased along with the progression of DR. Multivariate logistic regression analysis showed that PDR is significantly associated with sarcopenia (OR 7.78, 95% CI 1.52 to 39.81, p=0.014) and low muscle strength (OR 6.25, 95% CI 1.15 to 33.96, p=0.034). Multivariate linear regression analysis additionally showed that the existence of DR was significantly associated with the muscle quality (standardized β −0.136, p=0.005 for NPDR, standardized β −0.146, p=0.003 for PDR). Conclusions This study provides evidence that PDR is significantly associated with sarcopenia, and the existence of DR increases the risk for low muscle quality in patients with type 2 diabetes.

AB - Objective To examine whether the existence and severity of diabetic retinopathy (DR) could be associated with the prevalent sarcopenia and muscle quality in patients with type 2 diabetes. Research design and methods This is a cross-sectional study of 316 patients with type 2 diabetes (mean age 65±12 years; 38% female). Body compositions were measured by the dual-energy X-ray absorptiometry. Patients were divided into three groups: patients without DR (NDR), with non-proliferative DR (NPDR) and proliferative DR (PDR). Sarcopenia was diagnosed according to the criteria for Asians, using both skeletal muscle index (SMI) and grip strength (kg). Muscle quality was also determined by the grip strength divided by SMI. Logistic regression analyses were carried out to assess the cross-sectional association of the severity of DR with sarcopenia. In addition, linear regression analyses were performed to determine the associations between DR and muscle quality. Selection of covariates in the multivariate logistic and linear regression analyses was done by a stepwise procedure. Results Among the patients examined, NDR, NPDR and PDR were diagnosed in 261, 38 and 17 patients, respectively. The prevalence of sarcopenia significantly increased along with the progression of DR. Multivariate logistic regression analysis showed that PDR is significantly associated with sarcopenia (OR 7.78, 95% CI 1.52 to 39.81, p=0.014) and low muscle strength (OR 6.25, 95% CI 1.15 to 33.96, p=0.034). Multivariate linear regression analysis additionally showed that the existence of DR was significantly associated with the muscle quality (standardized β −0.136, p=0.005 for NPDR, standardized β −0.146, p=0.003 for PDR). Conclusions This study provides evidence that PDR is significantly associated with sarcopenia, and the existence of DR increases the risk for low muscle quality in patients with type 2 diabetes.

UR - http://www.scopus.com/inward/record.url?scp=85019981281&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85019981281&partnerID=8YFLogxK

U2 - 10.1136/bmjdrc-2017-000404

DO - 10.1136/bmjdrc-2017-000404

M3 - Article

AN - SCOPUS:85019981281

VL - 5

JO - BMJ Open Diabetes Research and Care

JF - BMJ Open Diabetes Research and Care

SN - 2052-4897

IS - 1

M1 - e000404

ER -