Association of endometrial epithelial metaplasias with endometrial carcinoma and hyperplasia in Japanese and American women

Tsunehisa Kaku, Steven G. Silverberg, Naoki Tsukamoto, Nobuhiro Tsuruchi, Toshiharu Kamura, Toshiaki Saito, Hitoo Nakano

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31 Citations (Scopus)

Abstract

We reviewed endometrial tissue from 166 cases of endometrial adenocarcinoma and hyperplasia—91 seen at Kyushu University, Fukuoka, Japan, and 75 at George Washington University, Washington, D.C., U.S.A.—to compare the prevalence of epithelial metaplastic changes in the two populations. Metaplasias were more common in the benign endometrium associated with carcinoma at George Washington University (78%) than at Kyushu University (54%). They were associated with carcinomas of lower grade and accompanied by hyperplasia at both institutions. These results indicate that endometrial metaplasias, like endometrial hyperplasias, tend to be associated with less virulent endometrial carcinomas and to be more common in American women (who represent a high-risk population for endometrial carcinoma) than in Japanese women (in whom the risk is low but rising).

Original languageEnglish
Pages (from-to)297-300
Number of pages4
JournalInternational Journal of Gynecological Pathology
Volume12
Issue number4
DOIs
Publication statusPublished - Oct 1993

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Obstetrics and Gynaecology

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