Association of general fatigue with cellular immune indicators among healthy white-collar employees

Akinori Nakata, Masahiro Irie, Masaya Takahashi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: Although fatigue is a common complaint in the working population, underlying immunological mechanisms are not well understood. This study investigated the association of general fatigue with cellular immune indicators. Methods: A total of 148 healthy white-collar employees (70% men) underwent a blood draw for the measurement of natural killer (NK), B, and T cell counts as well as NK cell cytotoxicity (NKCC) and completed two different fatigue scales, that is, Profile of Mood State (POMS) and Maastricht Questionnaire (MQ). Results: Multiple linear regression analyses revealed that POMS fatigue score was significantly associated with decreases of NK cells (β =-.407) and NKCC (β =-.215), whereas MQ fatigue score was significantly associated with reduced NK cells (β =-.290) but not with NKCC (β =-.127). Conclusion: The results suggest that general fatigue may be related to impaired NK cell competency among healthy employees.

Original languageEnglish
Pages (from-to)1078-1086
Number of pages9
JournalJournal of Occupational and Environmental Medicine
Volume53
Issue number9
DOIs
Publication statusPublished - Jan 1 2011

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Natural Killer Cells
Fatigue
Natural Killer T-Cells
Linear Models
B-Lymphocytes
Cell Count
Regression Analysis
Population
Surveys and Questionnaires

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

Cite this

Association of general fatigue with cellular immune indicators among healthy white-collar employees. / Nakata, Akinori; Irie, Masahiro; Takahashi, Masaya.

In: Journal of Occupational and Environmental Medicine, Vol. 53, No. 9, 01.01.2011, p. 1078-1086.

Research output: Contribution to journalArticle

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