Association of general fatigue with cellular immune indicators among healthy white-collar employees

Akinori Nakata, Masahiro Irie, Masaya Takahashi

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)

    Abstract

    Objective: Although fatigue is a common complaint in the working population, underlying immunological mechanisms are not well understood. This study investigated the association of general fatigue with cellular immune indicators. Methods: A total of 148 healthy white-collar employees (70% men) underwent a blood draw for the measurement of natural killer (NK), B, and T cell counts as well as NK cell cytotoxicity (NKCC) and completed two different fatigue scales, that is, Profile of Mood State (POMS) and Maastricht Questionnaire (MQ). Results: Multiple linear regression analyses revealed that POMS fatigue score was significantly associated with decreases of NK cells (β =-.407) and NKCC (β =-.215), whereas MQ fatigue score was significantly associated with reduced NK cells (β =-.290) but not with NKCC (β =-.127). Conclusion: The results suggest that general fatigue may be related to impaired NK cell competency among healthy employees.

    Original languageEnglish
    Pages (from-to)1078-1086
    Number of pages9
    JournalJournal of Occupational and Environmental Medicine
    Volume53
    Issue number9
    DOIs
    Publication statusPublished - Sep 2011

    All Science Journal Classification (ASJC) codes

    • Public Health, Environmental and Occupational Health

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