Abstract
Objective: Although fatigue is a common complaint in the working population, underlying immunological mechanisms are not well understood. This study investigated the association of general fatigue with cellular immune indicators. Methods: A total of 148 healthy white-collar employees (70% men) underwent a blood draw for the measurement of natural killer (NK), B, and T cell counts as well as NK cell cytotoxicity (NKCC) and completed two different fatigue scales, that is, Profile of Mood State (POMS) and Maastricht Questionnaire (MQ). Results: Multiple linear regression analyses revealed that POMS fatigue score was significantly associated with decreases of NK cells (β =-.407) and NKCC (β =-.215), whereas MQ fatigue score was significantly associated with reduced NK cells (β =-.290) but not with NKCC (β =-.127). Conclusion: The results suggest that general fatigue may be related to impaired NK cell competency among healthy employees.
| Original language | English |
|---|---|
| Pages (from-to) | 1078-1086 |
| Number of pages | 9 |
| Journal | Journal of Occupational and Environmental Medicine |
| Volume | 53 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Jan 1 2011 |
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All Science Journal Classification (ASJC) codes
- Public Health, Environmental and Occupational Health
Cite this
Association of general fatigue with cellular immune indicators among healthy white-collar employees. / Nakata, Akinori; Irie, Masahiro; Takahashi, Masaya.
In: Journal of Occupational and Environmental Medicine, Vol. 53, No. 9, 01.01.2011, p. 1078-1086.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association of general fatigue with cellular immune indicators among healthy white-collar employees
AU - Nakata, Akinori
AU - Irie, Masahiro
AU - Takahashi, Masaya
PY - 2011/1/1
Y1 - 2011/1/1
N2 - Objective: Although fatigue is a common complaint in the working population, underlying immunological mechanisms are not well understood. This study investigated the association of general fatigue with cellular immune indicators. Methods: A total of 148 healthy white-collar employees (70% men) underwent a blood draw for the measurement of natural killer (NK), B, and T cell counts as well as NK cell cytotoxicity (NKCC) and completed two different fatigue scales, that is, Profile of Mood State (POMS) and Maastricht Questionnaire (MQ). Results: Multiple linear regression analyses revealed that POMS fatigue score was significantly associated with decreases of NK cells (β =-.407) and NKCC (β =-.215), whereas MQ fatigue score was significantly associated with reduced NK cells (β =-.290) but not with NKCC (β =-.127). Conclusion: The results suggest that general fatigue may be related to impaired NK cell competency among healthy employees.
AB - Objective: Although fatigue is a common complaint in the working population, underlying immunological mechanisms are not well understood. This study investigated the association of general fatigue with cellular immune indicators. Methods: A total of 148 healthy white-collar employees (70% men) underwent a blood draw for the measurement of natural killer (NK), B, and T cell counts as well as NK cell cytotoxicity (NKCC) and completed two different fatigue scales, that is, Profile of Mood State (POMS) and Maastricht Questionnaire (MQ). Results: Multiple linear regression analyses revealed that POMS fatigue score was significantly associated with decreases of NK cells (β =-.407) and NKCC (β =-.215), whereas MQ fatigue score was significantly associated with reduced NK cells (β =-.290) but not with NKCC (β =-.127). Conclusion: The results suggest that general fatigue may be related to impaired NK cell competency among healthy employees.
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U2 - 10.1097/JOM.0b013e318229a938
DO - 10.1097/JOM.0b013e318229a938
M3 - Article
VL - 53
SP - 1078
EP - 1086
JO - Journal of Occupational and Environmental Medicine
JF - Journal of Occupational and Environmental Medicine
SN - 1076-2752
IS - 9
ER -