Association of HLA-DRB1*0803 and *1602 with the susceptibility to primary biliary cirrhosis

Tamotsu Mukai, Akinori Kimura, Hiromi Ishibashi, Takehiko Sasazuki, Michio Sata, Toshihiro Maruyama, Hironori Sakai, Yoshiyuki Niho

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15 Citations (Scopus)

Abstract

Forty-eight patients with primary biliary cirrhosis (PBC) and 336 healthy individuals were examined for HLA-DR, DQ and DP alleles, by DNA typing based on the polymerase chain reaction (PCR) sequence-specific oligonucleotide probe (SSOP) method. Frequencies of HLA-DRB1*1602, DRB1*0803, DQB1*0502, DQB1*0601 and DPB1*0202 were found to be increased in the patients. These HLA alleles are in linkage disequilibria consisting of DRB1*1602-DQB1*0502 and DRB1*0803-DQB1*0601-DPB1*0202 haplotypes. Since the frequencies of DRB1*1401 and DRB1*1502, that are in linkage disequilibria with DQB1*0502 and DQB1*0601, respectively, were not increased in the patients, the susceptibility to PBC was suggested to be controlled by the HLA-DRB1 locus. In contrast, the frequency of HLA-DQB1*0302 was decreased in the patients, while the frequency of each DRB1 allele in linkage disequilibria with DQB1*0302 did not differ significantly between the patient group and control group. This observation suggested that the resistance to PBC may be controlled by the HLA-DQ locus.

Original languageEnglish
Pages (from-to)207-212
Number of pages6
JournalInternational Hepatology Communications
Volume3
Issue number4
DOIs
Publication statusPublished - Apr 1995

All Science Journal Classification (ASJC) codes

  • Hepatology

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