Association of human leukocyte antigen class II alleles with severe acute respiratory syndrome in the Vietnamese population

Naoto Keicho, Satoru Itoyama, Koichi Kashiwase, Nguyen Chi Phi, Hoang Thuy Long, Le Dang Ha, Vo Van Ban, Bach Khanh Hoa, Nguyen Thi Le Hang, Minako Hijikata, Shinsaku Sakurada, Masahiro Satake, Katsushi Tokunaga, Takehiko Sasazuki, Tran Quy

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Excessive immune response is believed to play a role in the development of severe acute respiratory syndrome (SARS). Inhomogeneous spread of SARS led one to think of an Asian genetic predisposition and contribution of human leukocyte antigen (HLA) to the disease susceptibility. However, past case-control studies showed inconsistent results. In Viet Nam, of 62 patients with SARS, 44 participated in the present study together with 103 individuals who had contact with SARS patients and 50 without contact history. HLA-DRB1*12 was more frequently shown in SARS patients than in controls (corrected p = 0.042). HLA-DRB1*1202, the predominant allele in the Vietnamese population showed the strongest association with SARS in a dominant model (corrected p = 0.0065 and 0.0052, depending on the controls to be compared). Our results and accumulated data on HLA in the Asian populations would help in the understanding of associations with emerging infectious diseases.

Original languageEnglish
Pages (from-to)527-531
Number of pages5
JournalHuman Immunology
Volume70
Issue number7
DOIs
Publication statusPublished - Jul 1 2009
Externally publishedYes

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Severe Acute Respiratory Syndrome
HLA Antigens
Alleles
Population
Emerging Communicable Diseases
Vietnam
Disease Susceptibility
Genetic Predisposition to Disease
Case-Control Studies
History

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Association of human leukocyte antigen class II alleles with severe acute respiratory syndrome in the Vietnamese population. / Keicho, Naoto; Itoyama, Satoru; Kashiwase, Koichi; Phi, Nguyen Chi; Long, Hoang Thuy; Ha, Le Dang; Van Ban, Vo; Hoa, Bach Khanh; Hang, Nguyen Thi Le; Hijikata, Minako; Sakurada, Shinsaku; Satake, Masahiro; Tokunaga, Katsushi; Sasazuki, Takehiko; Quy, Tran.

In: Human Immunology, Vol. 70, No. 7, 01.07.2009, p. 527-531.

Research output: Contribution to journalArticle

Keicho, N, Itoyama, S, Kashiwase, K, Phi, NC, Long, HT, Ha, LD, Van Ban, V, Hoa, BK, Hang, NTL, Hijikata, M, Sakurada, S, Satake, M, Tokunaga, K, Sasazuki, T & Quy, T 2009, 'Association of human leukocyte antigen class II alleles with severe acute respiratory syndrome in the Vietnamese population', Human Immunology, vol. 70, no. 7, pp. 527-531. https://doi.org/10.1016/j.humimm.2009.05.006
Keicho, Naoto ; Itoyama, Satoru ; Kashiwase, Koichi ; Phi, Nguyen Chi ; Long, Hoang Thuy ; Ha, Le Dang ; Van Ban, Vo ; Hoa, Bach Khanh ; Hang, Nguyen Thi Le ; Hijikata, Minako ; Sakurada, Shinsaku ; Satake, Masahiro ; Tokunaga, Katsushi ; Sasazuki, Takehiko ; Quy, Tran. / Association of human leukocyte antigen class II alleles with severe acute respiratory syndrome in the Vietnamese population. In: Human Immunology. 2009 ; Vol. 70, No. 7. pp. 527-531.
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