Association of iron levels in hair with brain structures and functions in young adults

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Magistro Daniele, Yuko Sassa, Ryuta Kawashima

Research output: Contribution to journalArticle

Abstract

Background: Iron plays a critical role in normal brain functions and development, but it has also been known to have adverse neurological effects. Methods: Here, we investigated the associations of iron levels in hair with regional gray matter volume (rGMV), regional cerebral blood flow (rCBF), fractional anisotropy (FA), mean diffusivity (MD), and cognitive differences in a study cohort of 590 healthy young adults. Results: Our findings showed that high iron levels were associated with lower rGMV in areas including the hippocampus, lower rCBF in the anterior and posterior parts of the brain, greater FA in areas including the part of the splenium of the corpus callosum, lower MD in the overlapping area including the splenium of the corpus callosum, as well as greater MD in the left hippocampus and areas including the frontal lobe. Conclusion: These results are compatible with the notion that iron plays diverse roles in neural mechanisms in healthy young adults.

Original languageEnglish
Article number126436
JournalJournal of Trace Elements in Medicine and Biology
Volume58
DOIs
Publication statusPublished - Mar 2020
Externally publishedYes

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Hair
Young Adult
Brain
Cerebrovascular Circulation
Iron
Corpus Callosum
Anisotropy
Regional Blood Flow
Hippocampus
Blood
Frontal Lobe
Cohort Studies
Gray Matter

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Inorganic Chemistry

Cite this

Takeuchi, H., Taki, Y., Nouchi, R., Yokoyama, R., Kotozaki, Y., Nakagawa, S., ... Kawashima, R. (2020). Association of iron levels in hair with brain structures and functions in young adults. Journal of Trace Elements in Medicine and Biology, 58, [126436]. https://doi.org/10.1016/j.jtemb.2019.126436

Association of iron levels in hair with brain structures and functions in young adults. / Takeuchi, Hikaru; Taki, Yasuyuki; Nouchi, Rui; Yokoyama, Ryoichi; Kotozaki, Yuka; Nakagawa, Seishu; Sekiguchi, Atsushi; Iizuka, Kunio; Yamamoto, Yuki; Hanawa, Sugiko; Araki, Tsuyoshi; Miyauchi, Carlos Makoto; Sakaki, Kohei; Nozawa, Takayuki; Ikeda, Shigeyuki; Yokota, Susumu; Daniele, Magistro; Sassa, Yuko; Kawashima, Ryuta.

In: Journal of Trace Elements in Medicine and Biology, Vol. 58, 126436, 03.2020.

Research output: Contribution to journalArticle

Takeuchi, H, Taki, Y, Nouchi, R, Yokoyama, R, Kotozaki, Y, Nakagawa, S, Sekiguchi, A, Iizuka, K, Yamamoto, Y, Hanawa, S, Araki, T, Miyauchi, CM, Sakaki, K, Nozawa, T, Ikeda, S, Yokota, S, Daniele, M, Sassa, Y & Kawashima, R 2020, 'Association of iron levels in hair with brain structures and functions in young adults', Journal of Trace Elements in Medicine and Biology, vol. 58, 126436. https://doi.org/10.1016/j.jtemb.2019.126436
Takeuchi, Hikaru ; Taki, Yasuyuki ; Nouchi, Rui ; Yokoyama, Ryoichi ; Kotozaki, Yuka ; Nakagawa, Seishu ; Sekiguchi, Atsushi ; Iizuka, Kunio ; Yamamoto, Yuki ; Hanawa, Sugiko ; Araki, Tsuyoshi ; Miyauchi, Carlos Makoto ; Sakaki, Kohei ; Nozawa, Takayuki ; Ikeda, Shigeyuki ; Yokota, Susumu ; Daniele, Magistro ; Sassa, Yuko ; Kawashima, Ryuta. / Association of iron levels in hair with brain structures and functions in young adults. In: Journal of Trace Elements in Medicine and Biology. 2020 ; Vol. 58.
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AU - Kotozaki, Yuka

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AU - Sekiguchi, Atsushi

AU - Iizuka, Kunio

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AU - Hanawa, Sugiko

AU - Araki, Tsuyoshi

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AU - Sakaki, Kohei

AU - Nozawa, Takayuki

AU - Ikeda, Shigeyuki

AU - Yokota, Susumu

AU - Daniele, Magistro

AU - Sassa, Yuko

AU - Kawashima, Ryuta

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