Association of mannose binding lectin (MBL) gene polymorphism and serum MBL concentration with characteristics and progression of systemic lupus erythematosus

R. Takahashi, A. Tsutsumi, K. Ohtani, Y. Muraki, D. Goto, I. Matsumoto, N. Wakamiya, T. Sumida

Research output: Contribution to journalArticle

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Abstract

Objective: To determine whether occurrence, characteristics, and progression of systemic lupus erythematosus (SLE) are associated with polymorphism of the mannose binding lectin (MBL) gene and with serum MBL concentration. Methods: Codon 54 MBL gene polymorphism of 147 patients with SLE and 160 healthy controls was determined by polymerase chain reaction-restriction fragment length polymorphism. Serum concentration of MBL was measured by enzyme immunoassay. Fluctuations of serum MBL were analysed with respect to disease characteristics and activity. Results: Frequency of homozygosity for codon 54 minority allele was 6% (9/147) in patients with SLE, and significantly higher than in controls (p = 0.0294, Fisher's exact test). MBL polymorphism in patients with SLE was not significantly associated with disease characteristics or immunological phenotypes. Patients homozygous for the B allele tended to have a higher risk of infection during treatment. Levels of C3 and CH50 were slightly, but significantly, associated with serum MBL concentration in patients with SLE homozygous for the majority allele. During the course of SLE, serum MBL concentration increased in 6/14 patients, and decreased in 7 after initiation of immunosuppressive treatment. Conclusions: MBL gene polymorphism influences susceptibility to SLE, but has no direct effect on disease characteristics. Serum MBL levels fluctuate during the course of SLE in individual patients. MBL genotyping may be useful in assessing the risk of infection during treatment of SLE.

Original languageEnglish
Pages (from-to)311-314
Number of pages4
JournalAnnals of the Rheumatic Diseases
Volume64
Issue number2
DOIs
Publication statusPublished - Feb 1 2005

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Mannose-Binding Lectin
Polymorphism
Systemic Lupus Erythematosus
Genes
Serum
Alleles
Codon
Polymerase chain reaction
Immunosuppressive Agents
Infection
Immunoenzyme Techniques
Restriction Fragment Length Polymorphisms
Therapeutics

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

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Association of mannose binding lectin (MBL) gene polymorphism and serum MBL concentration with characteristics and progression of systemic lupus erythematosus. / Takahashi, R.; Tsutsumi, A.; Ohtani, K.; Muraki, Y.; Goto, D.; Matsumoto, I.; Wakamiya, N.; Sumida, T.

In: Annals of the Rheumatic Diseases, Vol. 64, No. 2, 01.02.2005, p. 311-314.

Research output: Contribution to journalArticle

Takahashi, R. ; Tsutsumi, A. ; Ohtani, K. ; Muraki, Y. ; Goto, D. ; Matsumoto, I. ; Wakamiya, N. ; Sumida, T. / Association of mannose binding lectin (MBL) gene polymorphism and serum MBL concentration with characteristics and progression of systemic lupus erythematosus. In: Annals of the Rheumatic Diseases. 2005 ; Vol. 64, No. 2. pp. 311-314.
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