Association of MBL gene polymorphisms with major bacterial infection in patients treated with high-dose chemotherapy and autologus PBSCT

T. Horiuchi, H. Gondo, H. Miyagawa, J. Otsuka, S. Inaba, K. Nagafuji, K. Takase, H. Tsukamoto, T. Koyama, H. Mitoma, Y. Tamimoto, Y. Miyagi, T. Tahira, K. Hayashi, C. Hashimura, S. Okamura, M. Harada

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Abstract

A growing body of evidence indicates that genetic factors are involved in an increased risk of infection. We investigated whether mannose-binding lectin (MBL) gene polymorphisms that cause low levels of MBL are associated with the occurrence of major infections in patients, mainly bearing hematological malignancies, after high-dose chemotherapy (HDT) rescued by autologous peripheral blood stem cell transplantation (auto-PBSCT). A retrospective evaluation of 113 patients treated with HDT and auto-PBSCT revealed that the low-producing genotypes, B/B and B/LXA, were associated with major bacterial infection (P = 0.0016, OR 7.9). We next performed a nation-wide large-scale study to assess the allele frequency of the MBL coding mutation in a total of 2623 healthy individuals in Japan. The frequency of allele B was estimated to be ∼ 0.2, almost the same in seven different areas of Japan. This common occurrence suggests that MBL deficiency may play an important role in the clinical settings of immunosuppression.

Original languageEnglish
Pages (from-to)162-166
Number of pages5
JournalGenes and Immunity
Volume6
Issue number2
DOIs
Publication statusPublished - Mar 1 2005

All Science Journal Classification (ASJC) codes

  • Immunology
  • Genetics
  • Genetics(clinical)

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    Horiuchi, T., Gondo, H., Miyagawa, H., Otsuka, J., Inaba, S., Nagafuji, K., Takase, K., Tsukamoto, H., Koyama, T., Mitoma, H., Tamimoto, Y., Miyagi, Y., Tahira, T., Hayashi, K., Hashimura, C., Okamura, S., & Harada, M. (2005). Association of MBL gene polymorphisms with major bacterial infection in patients treated with high-dose chemotherapy and autologus PBSCT. Genes and Immunity, 6(2), 162-166. https://doi.org/10.1038/sj.gene.6364165