TY - JOUR
T1 - Association of oral health status with the CD4+ cell count in children living with HIV in Phnom Penh, Cambodia
AU - Kikuchi, Kimiyo
AU - Furukawa, Yusuke
AU - Tuot, Sovannary
AU - Pal, Khuondyla
AU - Huot, Chantheany
AU - Yi, Siyan
N1 - Funding Information:
We acknowledge the contributions of all the participants and staff at the National Paediatric Hospital, Phnom Penh, as well as those of the research staff, to this study. This research was supported by the Kyushu University QR Program and JSPS KAKENHI Grant Number JP17H04658. The content of this article is solely the responsibility of the authors and does not necessarily represent the official views of the funding agencies.
Publisher Copyright:
© 2019, The Author(s).
PY - 2019/12/1
Y1 - 2019/12/1
N2 - The association between oral and overall health, and particularly between dental and immune health, in children living with HIV remains unclear. This study examined the association between the decayed, missing and filled teeth (DMFT) score and CD4+ cell counts in 142 children living with HIV aged 8–15 years (male, 51%) from Phnom Penh, Cambodia. Other indicators of oral health (e.g., debris index, salivary flow, salivary pH and oral health-related quality of life) and overall health (e.g., nutritional status and quality of life) were also evaluated. DMFT scores were negatively associated with the CD4+ cell count in male children (β: −0.13, 95% confidence interval [CI]: −0.25, −0.02). In all children, positive associations were observed between salivary pH and CD4+ count (β: −0.645, 95% CI: 0.02, 1.25) and between salivary flow and height-for-age Z-score (β: 1.22, 95% CI: 0.50, 1.95). The debris index was negatively associated with the height-for-age Z-score (β: −2.04, 95% CI: −3.38, −0.71). In summary, oral health was associated with immune and nutritional status. Oral health policies for children living with HIV should be emphasised, and further studies should evaluate the mechanism underlying the relationship between oral and overall health.
AB - The association between oral and overall health, and particularly between dental and immune health, in children living with HIV remains unclear. This study examined the association between the decayed, missing and filled teeth (DMFT) score and CD4+ cell counts in 142 children living with HIV aged 8–15 years (male, 51%) from Phnom Penh, Cambodia. Other indicators of oral health (e.g., debris index, salivary flow, salivary pH and oral health-related quality of life) and overall health (e.g., nutritional status and quality of life) were also evaluated. DMFT scores were negatively associated with the CD4+ cell count in male children (β: −0.13, 95% confidence interval [CI]: −0.25, −0.02). In all children, positive associations were observed between salivary pH and CD4+ count (β: −0.645, 95% CI: 0.02, 1.25) and between salivary flow and height-for-age Z-score (β: 1.22, 95% CI: 0.50, 1.95). The debris index was negatively associated with the height-for-age Z-score (β: −2.04, 95% CI: −3.38, −0.71). In summary, oral health was associated with immune and nutritional status. Oral health policies for children living with HIV should be emphasised, and further studies should evaluate the mechanism underlying the relationship between oral and overall health.
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U2 - 10.1038/s41598-019-51077-0
DO - 10.1038/s41598-019-51077-0
M3 - Article
C2 - 31601886
AN - SCOPUS:85073099655
SN - 2045-2322
VL - 9
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 14610
ER -
