Abstract
Background To investigate the association of both latent autoimmune diabetes in adults (LADA) and type 2 diabetes (T2DM) with muscle mass and function (sarcopenia). Methods Japanese patients with LADA (N = 20), T2DM (N = 208), and control subjects (N = 41) were included in this cross-sectional study. The definition of LADA was based on age of onset (≥ 30), positive glutamic acid decarboxylase autoantibodies, and insulin requirement within the first 6 months after diagnosis. Sarcopenia was diagnosed by the criteria for Asians, using skeletal muscle index (male < 7.0 and female < 5.4) and grip strength (male < 26.0 kg and female < 18.0 kg). The odds ratio (OR) with a 95% confidence interval (CI) was estimated using logistic regression. Results The prevalence of sarcopenia was higher in LADA (35.0%) than in either T2DM (13.3%) or control subjects (9.8%). LADA was significantly associated with an increased risk for sarcopenia in a multivariate model in which age and body mass index were incorporated (OR: 9.57, 95% CI: 1.86–49.27). In contrast, T2DM tended to be associated with an increased risk for sarcopenia (OR: 2.99, 95% CI: 0.83–10.80). Conclusions This study provides evidence that patients with LADA are at a high risk for sarcopenia compared to those with T2DM or to control subjects.
| Original language | English |
|---|---|
| Pages (from-to) | 992-996 |
| Number of pages | 5 |
| Journal | Journal of Diabetes and Its Complications |
| Volume | 31 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 2017 |
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All Science Journal Classification (ASJC) codes
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
- Endocrinology
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Association of sarcopenia with both latent autoimmune diabetes in adults and type 2 diabetes : A cross-sectional study. / Bouchi, Ryotaro; Fukuda, Tatsuya; Takeuchi, Takato; Nakano, Yujiro; Murakami, Masanori; Minami, Isao; Izumiyama, Hajime; Hashimoto, Koshi; Yoshimoto, Takanobu; Ogawa, Yoshihiro.
In: Journal of Diabetes and Its Complications, Vol. 31, No. 6, 06.2017, p. 992-996.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association of sarcopenia with both latent autoimmune diabetes in adults and type 2 diabetes
T2 - A cross-sectional study
AU - Bouchi, Ryotaro
AU - Fukuda, Tatsuya
AU - Takeuchi, Takato
AU - Nakano, Yujiro
AU - Murakami, Masanori
AU - Minami, Isao
AU - Izumiyama, Hajime
AU - Hashimoto, Koshi
AU - Yoshimoto, Takanobu
AU - Ogawa, Yoshihiro
PY - 2017/6
Y1 - 2017/6
N2 - Background To investigate the association of both latent autoimmune diabetes in adults (LADA) and type 2 diabetes (T2DM) with muscle mass and function (sarcopenia). Methods Japanese patients with LADA (N = 20), T2DM (N = 208), and control subjects (N = 41) were included in this cross-sectional study. The definition of LADA was based on age of onset (≥ 30), positive glutamic acid decarboxylase autoantibodies, and insulin requirement within the first 6 months after diagnosis. Sarcopenia was diagnosed by the criteria for Asians, using skeletal muscle index (male < 7.0 and female < 5.4) and grip strength (male < 26.0 kg and female < 18.0 kg). The odds ratio (OR) with a 95% confidence interval (CI) was estimated using logistic regression. Results The prevalence of sarcopenia was higher in LADA (35.0%) than in either T2DM (13.3%) or control subjects (9.8%). LADA was significantly associated with an increased risk for sarcopenia in a multivariate model in which age and body mass index were incorporated (OR: 9.57, 95% CI: 1.86–49.27). In contrast, T2DM tended to be associated with an increased risk for sarcopenia (OR: 2.99, 95% CI: 0.83–10.80). Conclusions This study provides evidence that patients with LADA are at a high risk for sarcopenia compared to those with T2DM or to control subjects.
AB - Background To investigate the association of both latent autoimmune diabetes in adults (LADA) and type 2 diabetes (T2DM) with muscle mass and function (sarcopenia). Methods Japanese patients with LADA (N = 20), T2DM (N = 208), and control subjects (N = 41) were included in this cross-sectional study. The definition of LADA was based on age of onset (≥ 30), positive glutamic acid decarboxylase autoantibodies, and insulin requirement within the first 6 months after diagnosis. Sarcopenia was diagnosed by the criteria for Asians, using skeletal muscle index (male < 7.0 and female < 5.4) and grip strength (male < 26.0 kg and female < 18.0 kg). The odds ratio (OR) with a 95% confidence interval (CI) was estimated using logistic regression. Results The prevalence of sarcopenia was higher in LADA (35.0%) than in either T2DM (13.3%) or control subjects (9.8%). LADA was significantly associated with an increased risk for sarcopenia in a multivariate model in which age and body mass index were incorporated (OR: 9.57, 95% CI: 1.86–49.27). In contrast, T2DM tended to be associated with an increased risk for sarcopenia (OR: 2.99, 95% CI: 0.83–10.80). Conclusions This study provides evidence that patients with LADA are at a high risk for sarcopenia compared to those with T2DM or to control subjects.
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UR - http://www.scopus.com/inward/citedby.url?scp=85016080116&partnerID=8YFLogxK
U2 - 10.1016/j.jdiacomp.2017.02.021
DO - 10.1016/j.jdiacomp.2017.02.021
M3 - Article
C2 - 28347695
AN - SCOPUS:85016080116
VL - 31
SP - 992
EP - 996
JO - Journal of Diabetes and its Complications
JF - Journal of Diabetes and its Complications
SN - 1056-8727
IS - 6
ER -