Association of sarcopenia with both latent autoimmune diabetes in adults and type 2 diabetes: A cross-sectional study

Ryotaro Bouchi, Tatsuya Fukuda, Takato Takeuchi, Yujiro Nakano, Masanori Murakami, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto, Yoshihiro Ogawa

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background To investigate the association of both latent autoimmune diabetes in adults (LADA) and type 2 diabetes (T2DM) with muscle mass and function (sarcopenia). Methods Japanese patients with LADA (N = 20), T2DM (N = 208), and control subjects (N = 41) were included in this cross-sectional study. The definition of LADA was based on age of onset (≥ 30), positive glutamic acid decarboxylase autoantibodies, and insulin requirement within the first 6 months after diagnosis. Sarcopenia was diagnosed by the criteria for Asians, using skeletal muscle index (male < 7.0 and female < 5.4) and grip strength (male < 26.0 kg and female < 18.0 kg). The odds ratio (OR) with a 95% confidence interval (CI) was estimated using logistic regression. Results The prevalence of sarcopenia was higher in LADA (35.0%) than in either T2DM (13.3%) or control subjects (9.8%). LADA was significantly associated with an increased risk for sarcopenia in a multivariate model in which age and body mass index were incorporated (OR: 9.57, 95% CI: 1.86–49.27). In contrast, T2DM tended to be associated with an increased risk for sarcopenia (OR: 2.99, 95% CI: 0.83–10.80). Conclusions This study provides evidence that patients with LADA are at a high risk for sarcopenia compared to those with T2DM or to control subjects.

Original languageEnglish
Pages (from-to)992-996
Number of pages5
JournalJournal of Diabetes and Its Complications
Volume31
Issue number6
DOIs
Publication statusPublished - Jun 2017

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Sarcopenia
Type 2 Diabetes Mellitus
Cross-Sectional Studies
Odds Ratio
Confidence Intervals
Glutamate Decarboxylase
Hand Strength
Age of Onset
Autoantibodies
Latent Autoimmune Diabetes in Adults
Skeletal Muscle
Body Mass Index
Logistic Models
Insulin
Muscles

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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Association of sarcopenia with both latent autoimmune diabetes in adults and type 2 diabetes : A cross-sectional study. / Bouchi, Ryotaro; Fukuda, Tatsuya; Takeuchi, Takato; Nakano, Yujiro; Murakami, Masanori; Minami, Isao; Izumiyama, Hajime; Hashimoto, Koshi; Yoshimoto, Takanobu; Ogawa, Yoshihiro.

In: Journal of Diabetes and Its Complications, Vol. 31, No. 6, 06.2017, p. 992-996.

Research output: Contribution to journalArticle

Bouchi, R, Fukuda, T, Takeuchi, T, Nakano, Y, Murakami, M, Minami, I, Izumiyama, H, Hashimoto, K, Yoshimoto, T & Ogawa, Y 2017, 'Association of sarcopenia with both latent autoimmune diabetes in adults and type 2 diabetes: A cross-sectional study', Journal of Diabetes and Its Complications, vol. 31, no. 6, pp. 992-996. https://doi.org/10.1016/j.jdiacomp.2017.02.021
Bouchi, Ryotaro ; Fukuda, Tatsuya ; Takeuchi, Takato ; Nakano, Yujiro ; Murakami, Masanori ; Minami, Isao ; Izumiyama, Hajime ; Hashimoto, Koshi ; Yoshimoto, Takanobu ; Ogawa, Yoshihiro. / Association of sarcopenia with both latent autoimmune diabetes in adults and type 2 diabetes : A cross-sectional study. In: Journal of Diabetes and Its Complications. 2017 ; Vol. 31, No. 6. pp. 992-996.
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T1 - Association of sarcopenia with both latent autoimmune diabetes in adults and type 2 diabetes

T2 - A cross-sectional study

AU - Bouchi, Ryotaro

AU - Fukuda, Tatsuya

AU - Takeuchi, Takato

AU - Nakano, Yujiro

AU - Murakami, Masanori

AU - Minami, Isao

AU - Izumiyama, Hajime

AU - Hashimoto, Koshi

AU - Yoshimoto, Takanobu

AU - Ogawa, Yoshihiro

PY - 2017/6

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N2 - Background To investigate the association of both latent autoimmune diabetes in adults (LADA) and type 2 diabetes (T2DM) with muscle mass and function (sarcopenia). Methods Japanese patients with LADA (N = 20), T2DM (N = 208), and control subjects (N = 41) were included in this cross-sectional study. The definition of LADA was based on age of onset (≥ 30), positive glutamic acid decarboxylase autoantibodies, and insulin requirement within the first 6 months after diagnosis. Sarcopenia was diagnosed by the criteria for Asians, using skeletal muscle index (male < 7.0 and female < 5.4) and grip strength (male < 26.0 kg and female < 18.0 kg). The odds ratio (OR) with a 95% confidence interval (CI) was estimated using logistic regression. Results The prevalence of sarcopenia was higher in LADA (35.0%) than in either T2DM (13.3%) or control subjects (9.8%). LADA was significantly associated with an increased risk for sarcopenia in a multivariate model in which age and body mass index were incorporated (OR: 9.57, 95% CI: 1.86–49.27). In contrast, T2DM tended to be associated with an increased risk for sarcopenia (OR: 2.99, 95% CI: 0.83–10.80). Conclusions This study provides evidence that patients with LADA are at a high risk for sarcopenia compared to those with T2DM or to control subjects.

AB - Background To investigate the association of both latent autoimmune diabetes in adults (LADA) and type 2 diabetes (T2DM) with muscle mass and function (sarcopenia). Methods Japanese patients with LADA (N = 20), T2DM (N = 208), and control subjects (N = 41) were included in this cross-sectional study. The definition of LADA was based on age of onset (≥ 30), positive glutamic acid decarboxylase autoantibodies, and insulin requirement within the first 6 months after diagnosis. Sarcopenia was diagnosed by the criteria for Asians, using skeletal muscle index (male < 7.0 and female < 5.4) and grip strength (male < 26.0 kg and female < 18.0 kg). The odds ratio (OR) with a 95% confidence interval (CI) was estimated using logistic regression. Results The prevalence of sarcopenia was higher in LADA (35.0%) than in either T2DM (13.3%) or control subjects (9.8%). LADA was significantly associated with an increased risk for sarcopenia in a multivariate model in which age and body mass index were incorporated (OR: 9.57, 95% CI: 1.86–49.27). In contrast, T2DM tended to be associated with an increased risk for sarcopenia (OR: 2.99, 95% CI: 0.83–10.80). Conclusions This study provides evidence that patients with LADA are at a high risk for sarcopenia compared to those with T2DM or to control subjects.

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