Association of serum lipocalin-type prostaglandin D synthase levels with subclinical atherosclerosis in untreated asymptomatic subjects

Yoshikazu Miwa, Hiroshi Oda, Yasuhiko Shiina, Kentaro Shikata, Motoo Tsushima, Satomi Nakano, Taro Maruyama, Shingo Kyotani, Naomi Eguchi, Yoshihiro Urade, Fumi Takahashi, Sachio Morimoto, Toshiyuki Sasaguri

Research output: Contribution to journalArticle

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Abstract

Recent studies suggest that lipocalin-type prostaglandin (PG) D synthase (L-PGDS), which converts PGH2 to PGD2, is implicated in the pathogenesis of atherosclerosis. However, clinical evidence for the association between serum L-PGDS levels and atherosclerosis has not been reported. In this study, we measured the serum L-PGDS concentration using sandwich enzyme-linked immunosorbent assay (ELISA) and investigated the association with traditional cardiovascular risk factors and surrogate atherosclerotic indices, such as the maximum score of the intima-media complex thickness of the carotid artery (C-IMTmax) and the brachial-ankle pulse wave velocity (ba-PWV), in 500 non-treated asymptomatic subjects. The serum concentration of L-PGDS was 0.56±0.01 (mean±SEM, range 0.25-1.27, median 0.54) mg/L. Serum L-PGDS levels increased with age and were higher in men than in women. Serum L-PGDS was higher in subjects with hypertension and increased with increasing numbers of the traditional atherosclerotic risk factors. When the subjects were divided into four groups according to the levels of serum L-PGDS, the age-adjusted values of C-IMTmax and ba-PWV were significantly increased in subjects with higher serum L-PGDS levels (quartile 3 and quartile 4) compared to those in the lowest quartile (quartile 1), for both genders. Multiple regression analysis including risk factors revealed that serum L-PGDS was an independent determinant for ba-PWV (β=0.130, p<0.001). Serum L-PGDS tended to associate with C-IMTmax but was not statistically significant (β=0.084, p=0.075). In conclusion, our results suggest that an increase in serum L-PGDS concentration is associated with the progression of atherosclerosis.

Original languageEnglish
Pages (from-to)1931-1939
Number of pages9
JournalHypertension Research
Volume31
Issue number10
DOIs
Publication statusPublished - Dec 1 2008

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prostaglandin R2 D-isomerase
Lipocalins
Atherosclerosis
Serum
Pulse Wave Analysis
Ankle
Arm
Prostaglandin H2
Prostaglandin D2

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Association of serum lipocalin-type prostaglandin D synthase levels with subclinical atherosclerosis in untreated asymptomatic subjects. / Miwa, Yoshikazu; Oda, Hiroshi; Shiina, Yasuhiko; Shikata, Kentaro; Tsushima, Motoo; Nakano, Satomi; Maruyama, Taro; Kyotani, Shingo; Eguchi, Naomi; Urade, Yoshihiro; Takahashi, Fumi; Morimoto, Sachio; Sasaguri, Toshiyuki.

In: Hypertension Research, Vol. 31, No. 10, 01.12.2008, p. 1931-1939.

Research output: Contribution to journalArticle

Miwa, Y, Oda, H, Shiina, Y, Shikata, K, Tsushima, M, Nakano, S, Maruyama, T, Kyotani, S, Eguchi, N, Urade, Y, Takahashi, F, Morimoto, S & Sasaguri, T 2008, 'Association of serum lipocalin-type prostaglandin D synthase levels with subclinical atherosclerosis in untreated asymptomatic subjects', Hypertension Research, vol. 31, no. 10, pp. 1931-1939. https://doi.org/10.1291/hypres.31.1931
Miwa, Yoshikazu ; Oda, Hiroshi ; Shiina, Yasuhiko ; Shikata, Kentaro ; Tsushima, Motoo ; Nakano, Satomi ; Maruyama, Taro ; Kyotani, Shingo ; Eguchi, Naomi ; Urade, Yoshihiro ; Takahashi, Fumi ; Morimoto, Sachio ; Sasaguri, Toshiyuki. / Association of serum lipocalin-type prostaglandin D synthase levels with subclinical atherosclerosis in untreated asymptomatic subjects. In: Hypertension Research. 2008 ; Vol. 31, No. 10. pp. 1931-1939.
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