Abstract
Aim: Recent studies have demonstrated that the Wnt signaling pathway plays an important role in bone metabolism. The purpose of this study was to examine whether the gene of secreted frizzled-related protein 1 (SFRP1), a Wnt antagonist, is involved in the etiology of osteoporosis using association study. Methods: Seven single nucleotide polymorphisms(SNP) in the SFRP1 gene were genotyped and analyzed for association with bone mineral density (BMD) in 931 Japanese women (63.5 ± 6.7 years old, mean ± standard deviation). Results: One SNP (rs16890444) located in intron and another (rs3242) located in the 3′-untranslated region of the sFRP1 gene were significantly associated with the lumbar spine BMD value, and BMD values for both the femoral neck and the total hip, respectively. Women with the T/T genotype of the former SNP had a lower BMD value of the lumbar spine (L2-L4) compared with those with C/C or C/T (BMD value adjusted for age, duration after menopause, and body mass index: 0.781 vs 0.830, P = 0.037), while women with the T/T genotype of the latter SNP had higher BMD values of femoral neck and total hip compared with those with C/C or C/T (adjusted BMD value: femoral neck, 0.721 vs 0.633, P = 0.025; total hip, 0.834 vs 0.737, P = 0.027). Conclusion: These results suggest that the SFRP1 may be a candidate gene for a BMD determinant, but further studies need to consolidate the present findings.
| Original language | English |
|---|---|
| Pages (from-to) | 304-309 |
| Number of pages | 6 |
| Journal | Geriatrics and Gerontology International |
| Volume | 9 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Aug 31 2009 |
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All Science Journal Classification (ASJC) codes
- Health(social science)
- Gerontology
- Geriatrics and Gerontology
Cite this
Association of single nucleotide polymorphisms in secreted frizzled-related protein 1 gene with bone mineral density in Japanese women. / Ohnaka, Keizo; Yamamoto, Ken; Nakamura, Kenjiro; Adachi, Masahiro; Kawate, Hisaya; Kono, Suminori; Takayanagi, Ryoichi.
In: Geriatrics and Gerontology International, Vol. 9, No. 3, 31.08.2009, p. 304-309.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association of single nucleotide polymorphisms in secreted frizzled-related protein 1 gene with bone mineral density in Japanese women
AU - Ohnaka, Keizo
AU - Yamamoto, Ken
AU - Nakamura, Kenjiro
AU - Adachi, Masahiro
AU - Kawate, Hisaya
AU - Kono, Suminori
AU - Takayanagi, Ryoichi
PY - 2009/8/31
Y1 - 2009/8/31
N2 - Aim: Recent studies have demonstrated that the Wnt signaling pathway plays an important role in bone metabolism. The purpose of this study was to examine whether the gene of secreted frizzled-related protein 1 (SFRP1), a Wnt antagonist, is involved in the etiology of osteoporosis using association study. Methods: Seven single nucleotide polymorphisms(SNP) in the SFRP1 gene were genotyped and analyzed for association with bone mineral density (BMD) in 931 Japanese women (63.5 ± 6.7 years old, mean ± standard deviation). Results: One SNP (rs16890444) located in intron and another (rs3242) located in the 3′-untranslated region of the sFRP1 gene were significantly associated with the lumbar spine BMD value, and BMD values for both the femoral neck and the total hip, respectively. Women with the T/T genotype of the former SNP had a lower BMD value of the lumbar spine (L2-L4) compared with those with C/C or C/T (BMD value adjusted for age, duration after menopause, and body mass index: 0.781 vs 0.830, P = 0.037), while women with the T/T genotype of the latter SNP had higher BMD values of femoral neck and total hip compared with those with C/C or C/T (adjusted BMD value: femoral neck, 0.721 vs 0.633, P = 0.025; total hip, 0.834 vs 0.737, P = 0.027). Conclusion: These results suggest that the SFRP1 may be a candidate gene for a BMD determinant, but further studies need to consolidate the present findings.
AB - Aim: Recent studies have demonstrated that the Wnt signaling pathway plays an important role in bone metabolism. The purpose of this study was to examine whether the gene of secreted frizzled-related protein 1 (SFRP1), a Wnt antagonist, is involved in the etiology of osteoporosis using association study. Methods: Seven single nucleotide polymorphisms(SNP) in the SFRP1 gene were genotyped and analyzed for association with bone mineral density (BMD) in 931 Japanese women (63.5 ± 6.7 years old, mean ± standard deviation). Results: One SNP (rs16890444) located in intron and another (rs3242) located in the 3′-untranslated region of the sFRP1 gene were significantly associated with the lumbar spine BMD value, and BMD values for both the femoral neck and the total hip, respectively. Women with the T/T genotype of the former SNP had a lower BMD value of the lumbar spine (L2-L4) compared with those with C/C or C/T (BMD value adjusted for age, duration after menopause, and body mass index: 0.781 vs 0.830, P = 0.037), while women with the T/T genotype of the latter SNP had higher BMD values of femoral neck and total hip compared with those with C/C or C/T (adjusted BMD value: femoral neck, 0.721 vs 0.633, P = 0.025; total hip, 0.834 vs 0.737, P = 0.027). Conclusion: These results suggest that the SFRP1 may be a candidate gene for a BMD determinant, but further studies need to consolidate the present findings.
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UR - http://www.scopus.com/inward/citedby.url?scp=69249100956&partnerID=8YFLogxK
U2 - 10.1111/j.1447-0594.2009.00540.x
DO - 10.1111/j.1447-0594.2009.00540.x
M3 - Article
C2 - 19702942
AN - SCOPUS:69249100956
VL - 9
SP - 304
EP - 309
JO - Geriatrics and Gerontology International
JF - Geriatrics and Gerontology International
SN - 1447-0594
IS - 3
ER -