Association of the HLA-DRB1 alleles with characteristic MRI features of Asian multiple sclerosis

T. Matsuoka, Takuya Matsushita, M. Osoegawa, Y. Kawano, M. Minohara, F. Mihara, Y. Nishimura, Y. Ohyagi, Jun-Ichi Kira

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Background: In Asian patients with multiple sclerosis (MS), a paucity of brain lesions and longitudinally extensive spinal cord lesions (LESCLs) extending three or more vertebral segments are characteristic findings on magnetic resonance imaging (MRI). We aimed to disclose possible factors contributing to the development of such MRI features. Method: Genotyping of HLA-DRB1 and -DPB1 alleles was performed in 121 consecutive Japanese patients with clinically definite MS based on the Poser criteria and 125 healthy controls. Possible factors associated with MRI features were determined by multiple logistic analysis. Patients with MS were classified based on the presence or absence of brain lesions fulfilling the Barkhof criteria (Barkhof brain lesions) and LESCLs. Barkhof brain lesion-negative (-) patients had a markedly lower frequency of HLA-DRB1ß0901 than controls (Pcorr < 0.05), whereas the frequency of DRB1ß1501 was increased in the Barkhof brain lesion-positive (+) group, although this increase was not significant after correction. No Barkhof(-)LESCL(+) patients carried DRB1ß0901 (Pcorr < 0.05), despite this being the most common allele in Japanese. The Barkhof(-)LESCL(-) group showed a significant increase in the frequency of DRB1ß0405 compared with controls (Pcorr < 0.05). None of the DPB1 alleles were significantly different among the groups. Using multiple logistic analysis, the absence of oligoclonal bands was positively associated with an absence of Barkhof brain lesions, whereas a higher EDSS score was positively associated with the presence of LESCLs; however, the presence of anti-aquaporin-4 antibodies was not associated with either feature. Conclusion: The characteristic MRI features in Asians are partly related to distinct HLA-DRB1 gene alleles and an absence of oligoclonal bands.

Original languageEnglish
Pages (from-to)1181-1190
Number of pages10
JournalMultiple Sclerosis
Volume14
Issue number9
DOIs
Publication statusPublished - Dec 1 2008

Fingerprint

HLA-DRB1 Chains
Multiple Sclerosis
Alleles
Magnetic Resonance Imaging
Spinal Cord
Brain
Oligoclonal Bands
Aquaporin 4
Antibodies
Genes

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Association of the HLA-DRB1 alleles with characteristic MRI features of Asian multiple sclerosis. / Matsuoka, T.; Matsushita, Takuya; Osoegawa, M.; Kawano, Y.; Minohara, M.; Mihara, F.; Nishimura, Y.; Ohyagi, Y.; Kira, Jun-Ichi.

In: Multiple Sclerosis, Vol. 14, No. 9, 01.12.2008, p. 1181-1190.

Research output: Contribution to journalArticle

Matsuoka, T, Matsushita, T, Osoegawa, M, Kawano, Y, Minohara, M, Mihara, F, Nishimura, Y, Ohyagi, Y & Kira, J-I 2008, 'Association of the HLA-DRB1 alleles with characteristic MRI features of Asian multiple sclerosis', Multiple Sclerosis, vol. 14, no. 9, pp. 1181-1190. https://doi.org/10.1177/1352458508097818
Matsuoka, T. ; Matsushita, Takuya ; Osoegawa, M. ; Kawano, Y. ; Minohara, M. ; Mihara, F. ; Nishimura, Y. ; Ohyagi, Y. ; Kira, Jun-Ichi. / Association of the HLA-DRB1 alleles with characteristic MRI features of Asian multiple sclerosis. In: Multiple Sclerosis. 2008 ; Vol. 14, No. 9. pp. 1181-1190.
@article{6eb97e97cc524db4b71e7ea8a5e75a10,
title = "Association of the HLA-DRB1 alleles with characteristic MRI features of Asian multiple sclerosis",
abstract = "Background: In Asian patients with multiple sclerosis (MS), a paucity of brain lesions and longitudinally extensive spinal cord lesions (LESCLs) extending three or more vertebral segments are characteristic findings on magnetic resonance imaging (MRI). We aimed to disclose possible factors contributing to the development of such MRI features. Method: Genotyping of HLA-DRB1 and -DPB1 alleles was performed in 121 consecutive Japanese patients with clinically definite MS based on the Poser criteria and 125 healthy controls. Possible factors associated with MRI features were determined by multiple logistic analysis. Patients with MS were classified based on the presence or absence of brain lesions fulfilling the Barkhof criteria (Barkhof brain lesions) and LESCLs. Barkhof brain lesion-negative (-) patients had a markedly lower frequency of HLA-DRB1{\ss}0901 than controls (Pcorr < 0.05), whereas the frequency of DRB1{\ss}1501 was increased in the Barkhof brain lesion-positive (+) group, although this increase was not significant after correction. No Barkhof(-)LESCL(+) patients carried DRB1{\ss}0901 (Pcorr < 0.05), despite this being the most common allele in Japanese. The Barkhof(-)LESCL(-) group showed a significant increase in the frequency of DRB1{\ss}0405 compared with controls (Pcorr < 0.05). None of the DPB1 alleles were significantly different among the groups. Using multiple logistic analysis, the absence of oligoclonal bands was positively associated with an absence of Barkhof brain lesions, whereas a higher EDSS score was positively associated with the presence of LESCLs; however, the presence of anti-aquaporin-4 antibodies was not associated with either feature. Conclusion: The characteristic MRI features in Asians are partly related to distinct HLA-DRB1 gene alleles and an absence of oligoclonal bands.",
author = "T. Matsuoka and Takuya Matsushita and M. Osoegawa and Y. Kawano and M. Minohara and F. Mihara and Y. Nishimura and Y. Ohyagi and Jun-Ichi Kira",
year = "2008",
month = "12",
day = "1",
doi = "10.1177/1352458508097818",
language = "English",
volume = "14",
pages = "1181--1190",
journal = "Multiple Sclerosis",
issn = "1352-4585",
publisher = "SAGE Publications Ltd",
number = "9",

}

TY - JOUR

T1 - Association of the HLA-DRB1 alleles with characteristic MRI features of Asian multiple sclerosis

AU - Matsuoka, T.

AU - Matsushita, Takuya

AU - Osoegawa, M.

AU - Kawano, Y.

AU - Minohara, M.

AU - Mihara, F.

AU - Nishimura, Y.

AU - Ohyagi, Y.

AU - Kira, Jun-Ichi

PY - 2008/12/1

Y1 - 2008/12/1

N2 - Background: In Asian patients with multiple sclerosis (MS), a paucity of brain lesions and longitudinally extensive spinal cord lesions (LESCLs) extending three or more vertebral segments are characteristic findings on magnetic resonance imaging (MRI). We aimed to disclose possible factors contributing to the development of such MRI features. Method: Genotyping of HLA-DRB1 and -DPB1 alleles was performed in 121 consecutive Japanese patients with clinically definite MS based on the Poser criteria and 125 healthy controls. Possible factors associated with MRI features were determined by multiple logistic analysis. Patients with MS were classified based on the presence or absence of brain lesions fulfilling the Barkhof criteria (Barkhof brain lesions) and LESCLs. Barkhof brain lesion-negative (-) patients had a markedly lower frequency of HLA-DRB1ß0901 than controls (Pcorr < 0.05), whereas the frequency of DRB1ß1501 was increased in the Barkhof brain lesion-positive (+) group, although this increase was not significant after correction. No Barkhof(-)LESCL(+) patients carried DRB1ß0901 (Pcorr < 0.05), despite this being the most common allele in Japanese. The Barkhof(-)LESCL(-) group showed a significant increase in the frequency of DRB1ß0405 compared with controls (Pcorr < 0.05). None of the DPB1 alleles were significantly different among the groups. Using multiple logistic analysis, the absence of oligoclonal bands was positively associated with an absence of Barkhof brain lesions, whereas a higher EDSS score was positively associated with the presence of LESCLs; however, the presence of anti-aquaporin-4 antibodies was not associated with either feature. Conclusion: The characteristic MRI features in Asians are partly related to distinct HLA-DRB1 gene alleles and an absence of oligoclonal bands.

AB - Background: In Asian patients with multiple sclerosis (MS), a paucity of brain lesions and longitudinally extensive spinal cord lesions (LESCLs) extending three or more vertebral segments are characteristic findings on magnetic resonance imaging (MRI). We aimed to disclose possible factors contributing to the development of such MRI features. Method: Genotyping of HLA-DRB1 and -DPB1 alleles was performed in 121 consecutive Japanese patients with clinically definite MS based on the Poser criteria and 125 healthy controls. Possible factors associated with MRI features were determined by multiple logistic analysis. Patients with MS were classified based on the presence or absence of brain lesions fulfilling the Barkhof criteria (Barkhof brain lesions) and LESCLs. Barkhof brain lesion-negative (-) patients had a markedly lower frequency of HLA-DRB1ß0901 than controls (Pcorr < 0.05), whereas the frequency of DRB1ß1501 was increased in the Barkhof brain lesion-positive (+) group, although this increase was not significant after correction. No Barkhof(-)LESCL(+) patients carried DRB1ß0901 (Pcorr < 0.05), despite this being the most common allele in Japanese. The Barkhof(-)LESCL(-) group showed a significant increase in the frequency of DRB1ß0405 compared with controls (Pcorr < 0.05). None of the DPB1 alleles were significantly different among the groups. Using multiple logistic analysis, the absence of oligoclonal bands was positively associated with an absence of Barkhof brain lesions, whereas a higher EDSS score was positively associated with the presence of LESCLs; however, the presence of anti-aquaporin-4 antibodies was not associated with either feature. Conclusion: The characteristic MRI features in Asians are partly related to distinct HLA-DRB1 gene alleles and an absence of oligoclonal bands.

UR - http://www.scopus.com/inward/record.url?scp=59249100549&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=59249100549&partnerID=8YFLogxK

U2 - 10.1177/1352458508097818

DO - 10.1177/1352458508097818

M3 - Article

C2 - 18952831

AN - SCOPUS:59249100549

VL - 14

SP - 1181

EP - 1190

JO - Multiple Sclerosis

JF - Multiple Sclerosis

SN - 1352-4585

IS - 9

ER -