Association of the interferon-γ receptor variant (Val14Met) with systemic lupus erythematosus

Yosuke Tanaka, Hitoshi Nakashima, Chizuko Hisano, Tsutomu Kohsaka, Yoshiaki Nemoto, Hiroaki Niiro, Teruhisa Otsuka, Takeshi Otsuka, Takashi Imamura, Yoshiyuki Niho

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53 Citations (Scopus)

Abstract

Genetic factors seem to play a significant role in susceptibility to systemic lupus erythematosus (SLE). The purpose of this study was to investigate whether the amino acid polymorphism (Val14Met) found within the IFN-γ receptor gene (IFNGR1) plays a prominent role in susceptibility to SLE. We found Val14Met located at the COOH terminal of the signal peptide of the IFN-γ receptor. There was a significant difference in this polymorphism frequency between SLE patients and healthy populations. To clarify whether this amino acid substitution resulted in the alteration of the receptor function, we evaluated the induction of HLA-DR antigen expression on B cells by IFN-γ stimulation. There was also a significant difference in the induction of HLA-DR by IFN-γ stimulation between B cells. Furthermore, an intracellular cytokine assay indicated that the Th1/Th2 balance of Th cells bearing the variant receptor shifted to Th2. The genetic polymorphism found within the IFN-γ receptor gene (Val14Met) may result in a shift to Th2, and this shift may increase susceptibility to SLE.

Original languageEnglish
Pages (from-to)266-271
Number of pages6
JournalImmunogenetics
Volume49
Issue number4
DOIs
Publication statusPublished - Mar 18 1999

All Science Journal Classification (ASJC) codes

  • Immunology
  • Genetics

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