Association of the serum endostatin level, renal function, and carotid atherosclerosis of healthy residents of Japan

Results from the kyushu and okinawa population study (KOPS)

Yoshifumi Kato, Norihiro Furusyo, Yuuki Tanaka, Sho Yamasaki, Takatsugu Ueyama, Koji Takayama, Fujiko Mitsumoto-Kaseida, Murata Masayuki, Hiroaki Ikezaki, Jun Hayashi

Research output: Contribution to journalArticle

Abstract

Aim: To analyze associations among the serum endostatin level, renal function, and carotid atherosclerosis of healthy residents of Japan. Methods: Among 1,057 Japanese residents who attended free public physical examinations between 2010 and 2011, we evaluated the data of 648 healthy residents (200 men and 448 women, age 24 to 84 years) for whom the serum endostatin level and common carotid intima-media thickness (IMT) were measured. Renal function was assessed by estimated glomerular filtration rate (eGFR). Multiple linear regression analysis was done to determine the association of eGFR and serum endostatin level after adjustment for known covariates. Mediation analysis was done using Baron and Kenny’s regression approach. Results: The median endostatin level was 63.7 ng/mL (interquartile range: 49.7–93.2). The mean eGFR was 78.4±14.8 mL/min/1.73m2. Univariate analysis showed that age (r =-0.37, P<0.01), non current smoking (85.8±13.0 vs. 77.5±14.8 mL/min/1.73 m2, P<0.01), hemoglobin A1c (r=-0.08, P=0.05), low-density lipo-protein-cholesterol (r =-0.13, P<0.01), uric acid (r =-0.15, P<0.01), carotid IMT (r=-0.11, P<0.01), and log-transformed endostatin (r=-0.36, P<0.01) were significantly associated with eGFR. In multiple linear regression analysis, log-transformed endostatin was significantly associated with eGFR (beta=-0.24, P<0.01). While, carotid IMT was no longer significant. Mediation analysis showed serum endostatin level to be a mediator in the association between carotid IMT and eGFR. Conclusions: The association between carotid IMT and eGFR is mediated by the serum endostatin level of healthy individuals.

Original languageEnglish
Pages (from-to)829-835
Number of pages7
JournalJournal of atherosclerosis and thrombosis
Volume25
Issue number9
DOIs
Publication statusPublished - Jan 1 2018

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Endostatins
Carotid Artery Diseases
Glomerular Filtration Rate
Japan
Carotid Intima-Media Thickness
Kidney
Serum
Population
Linear regression
Regression analysis
Linear Models
Regression Analysis
Uric Acid
Physical Examination
Hemoglobins
Smoking
Cholesterol

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine
  • Biochemistry, medical

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Association of the serum endostatin level, renal function, and carotid atherosclerosis of healthy residents of Japan : Results from the kyushu and okinawa population study (KOPS). / Kato, Yoshifumi; Furusyo, Norihiro; Tanaka, Yuuki; Yamasaki, Sho; Ueyama, Takatsugu; Takayama, Koji; Mitsumoto-Kaseida, Fujiko; Masayuki, Murata; Ikezaki, Hiroaki; Hayashi, Jun.

In: Journal of atherosclerosis and thrombosis, Vol. 25, No. 9, 01.01.2018, p. 829-835.

Research output: Contribution to journalArticle

Kato, Yoshifumi ; Furusyo, Norihiro ; Tanaka, Yuuki ; Yamasaki, Sho ; Ueyama, Takatsugu ; Takayama, Koji ; Mitsumoto-Kaseida, Fujiko ; Masayuki, Murata ; Ikezaki, Hiroaki ; Hayashi, Jun. / Association of the serum endostatin level, renal function, and carotid atherosclerosis of healthy residents of Japan : Results from the kyushu and okinawa population study (KOPS). In: Journal of atherosclerosis and thrombosis. 2018 ; Vol. 25, No. 9. pp. 829-835.
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T1 - Association of the serum endostatin level, renal function, and carotid atherosclerosis of healthy residents of Japan

T2 - Results from the kyushu and okinawa population study (KOPS)

AU - Kato, Yoshifumi

AU - Furusyo, Norihiro

AU - Tanaka, Yuuki

AU - Yamasaki, Sho

AU - Ueyama, Takatsugu

AU - Takayama, Koji

AU - Mitsumoto-Kaseida, Fujiko

AU - Masayuki, Murata

AU - Ikezaki, Hiroaki

AU - Hayashi, Jun

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Aim: To analyze associations among the serum endostatin level, renal function, and carotid atherosclerosis of healthy residents of Japan. Methods: Among 1,057 Japanese residents who attended free public physical examinations between 2010 and 2011, we evaluated the data of 648 healthy residents (200 men and 448 women, age 24 to 84 years) for whom the serum endostatin level and common carotid intima-media thickness (IMT) were measured. Renal function was assessed by estimated glomerular filtration rate (eGFR). Multiple linear regression analysis was done to determine the association of eGFR and serum endostatin level after adjustment for known covariates. Mediation analysis was done using Baron and Kenny’s regression approach. Results: The median endostatin level was 63.7 ng/mL (interquartile range: 49.7–93.2). The mean eGFR was 78.4±14.8 mL/min/1.73m2. Univariate analysis showed that age (r =-0.37, P<0.01), non current smoking (85.8±13.0 vs. 77.5±14.8 mL/min/1.73 m2, P<0.01), hemoglobin A1c (r=-0.08, P=0.05), low-density lipo-protein-cholesterol (r =-0.13, P<0.01), uric acid (r =-0.15, P<0.01), carotid IMT (r=-0.11, P<0.01), and log-transformed endostatin (r=-0.36, P<0.01) were significantly associated with eGFR. In multiple linear regression analysis, log-transformed endostatin was significantly associated with eGFR (beta=-0.24, P<0.01). While, carotid IMT was no longer significant. Mediation analysis showed serum endostatin level to be a mediator in the association between carotid IMT and eGFR. Conclusions: The association between carotid IMT and eGFR is mediated by the serum endostatin level of healthy individuals.

AB - Aim: To analyze associations among the serum endostatin level, renal function, and carotid atherosclerosis of healthy residents of Japan. Methods: Among 1,057 Japanese residents who attended free public physical examinations between 2010 and 2011, we evaluated the data of 648 healthy residents (200 men and 448 women, age 24 to 84 years) for whom the serum endostatin level and common carotid intima-media thickness (IMT) were measured. Renal function was assessed by estimated glomerular filtration rate (eGFR). Multiple linear regression analysis was done to determine the association of eGFR and serum endostatin level after adjustment for known covariates. Mediation analysis was done using Baron and Kenny’s regression approach. Results: The median endostatin level was 63.7 ng/mL (interquartile range: 49.7–93.2). The mean eGFR was 78.4±14.8 mL/min/1.73m2. Univariate analysis showed that age (r =-0.37, P<0.01), non current smoking (85.8±13.0 vs. 77.5±14.8 mL/min/1.73 m2, P<0.01), hemoglobin A1c (r=-0.08, P=0.05), low-density lipo-protein-cholesterol (r =-0.13, P<0.01), uric acid (r =-0.15, P<0.01), carotid IMT (r=-0.11, P<0.01), and log-transformed endostatin (r=-0.36, P<0.01) were significantly associated with eGFR. In multiple linear regression analysis, log-transformed endostatin was significantly associated with eGFR (beta=-0.24, P<0.01). While, carotid IMT was no longer significant. Mediation analysis showed serum endostatin level to be a mediator in the association between carotid IMT and eGFR. Conclusions: The association between carotid IMT and eGFR is mediated by the serum endostatin level of healthy individuals.

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