Association of variation in the MC4R gene with meat quality traits in a commercial pig population

Rang Kwon, Muhammad Cahyadi, Hee Bok Park, Dong Won Seo, Shil Jin, Sang Wook Kim, Yang Il Choi, Kwan Suk Kim, Takafumi Gotoh, Jun Heon Lee

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The melanocortin-4 receptor (MC4R) gene is known to encode a membrane-bound receptor protein and is a member of the melanocortin receptor family of genes. In mammals, these genes are involved in energy homeostasis and in regulating feeding behavior and body weight. The objective of the present study was to examine if there were any associations between variations in the MC4R gene with meat quality traits in a commercial pig population in Korea. Among the total of 593 commercial pigs, sire information was retrieved from 232 pigs. These animals were successfully genotyped for the c.892A>G (p. Asp298Asn) single nucleotide polymorphism (SNP) by using ThqI PCR-RFLP methods. Association analyses between this SNP and meat quality traits were performed using a general linear model (GLM) including sire effect. This SNP was significantly associated with backfat thickness (P<0.05), marbling (P<0.01). Interestingly, this SNP marker was also associated with volatile basic nitrogen after 14 days of storage (P<0.05). To our knowledge, it is the first results observed for the MC4R genotypes with volatile basic nitrogen after 14 days of storage in the commercial pig population. Therefore, these results suggest that the MC4R gene can be targeted in marker-assisted breeding for selecting pigs with good meat quality.

Original languageEnglish
Pages (from-to)113-118
Number of pages6
JournalJournal of the Faculty of Agriculture, Kyushu University
Volume60
Issue number1
Publication statusPublished - Jan 1 2015

Fingerprint

Receptor, Melanocortin, Type 4
Meat
meat quality
Swine
Single Nucleotide Polymorphism
receptors
single nucleotide polymorphism
swine
Population
Genes
genes
Nitrogen
sires
Melanocortin Receptors
Feeding Behavior
Korea
livestock breeding
Restriction Fragment Length Polymorphisms
marbling
Breeding

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Agronomy and Crop Science

Cite this

Kwon, R., Cahyadi, M., Park, H. B., Seo, D. W., Jin, S., Kim, S. W., ... Lee, J. H. (2015). Association of variation in the MC4R gene with meat quality traits in a commercial pig population. Journal of the Faculty of Agriculture, Kyushu University, 60(1), 113-118.

Association of variation in the MC4R gene with meat quality traits in a commercial pig population. / Kwon, Rang; Cahyadi, Muhammad; Park, Hee Bok; Seo, Dong Won; Jin, Shil; Kim, Sang Wook; Choi, Yang Il; Kim, Kwan Suk; Gotoh, Takafumi; Lee, Jun Heon.

In: Journal of the Faculty of Agriculture, Kyushu University, Vol. 60, No. 1, 01.01.2015, p. 113-118.

Research output: Contribution to journalArticle

Kwon, R, Cahyadi, M, Park, HB, Seo, DW, Jin, S, Kim, SW, Choi, YI, Kim, KS, Gotoh, T & Lee, JH 2015, 'Association of variation in the MC4R gene with meat quality traits in a commercial pig population', Journal of the Faculty of Agriculture, Kyushu University, vol. 60, no. 1, pp. 113-118.
Kwon, Rang ; Cahyadi, Muhammad ; Park, Hee Bok ; Seo, Dong Won ; Jin, Shil ; Kim, Sang Wook ; Choi, Yang Il ; Kim, Kwan Suk ; Gotoh, Takafumi ; Lee, Jun Heon. / Association of variation in the MC4R gene with meat quality traits in a commercial pig population. In: Journal of the Faculty of Agriculture, Kyushu University. 2015 ; Vol. 60, No. 1. pp. 113-118.
@article{c40248999c4b495d9dbe1bf03b513a8a,
title = "Association of variation in the MC4R gene with meat quality traits in a commercial pig population",
abstract = "The melanocortin-4 receptor (MC4R) gene is known to encode a membrane-bound receptor protein and is a member of the melanocortin receptor family of genes. In mammals, these genes are involved in energy homeostasis and in regulating feeding behavior and body weight. The objective of the present study was to examine if there were any associations between variations in the MC4R gene with meat quality traits in a commercial pig population in Korea. Among the total of 593 commercial pigs, sire information was retrieved from 232 pigs. These animals were successfully genotyped for the c.892A>G (p. Asp298Asn) single nucleotide polymorphism (SNP) by using ThqI PCR-RFLP methods. Association analyses between this SNP and meat quality traits were performed using a general linear model (GLM) including sire effect. This SNP was significantly associated with backfat thickness (P<0.05), marbling (P<0.01). Interestingly, this SNP marker was also associated with volatile basic nitrogen after 14 days of storage (P<0.05). To our knowledge, it is the first results observed for the MC4R genotypes with volatile basic nitrogen after 14 days of storage in the commercial pig population. Therefore, these results suggest that the MC4R gene can be targeted in marker-assisted breeding for selecting pigs with good meat quality.",
author = "Rang Kwon and Muhammad Cahyadi and Park, {Hee Bok} and Seo, {Dong Won} and Shil Jin and Kim, {Sang Wook} and Choi, {Yang Il} and Kim, {Kwan Suk} and Takafumi Gotoh and Lee, {Jun Heon}",
year = "2015",
month = "1",
day = "1",
language = "English",
volume = "60",
pages = "113--118",
journal = "Journal of the Faculty of Agriculture, Kyushu University",
issn = "0023-6152",
publisher = "Faculty of Agriculture, Kyushu University",
number = "1",

}

TY - JOUR

T1 - Association of variation in the MC4R gene with meat quality traits in a commercial pig population

AU - Kwon, Rang

AU - Cahyadi, Muhammad

AU - Park, Hee Bok

AU - Seo, Dong Won

AU - Jin, Shil

AU - Kim, Sang Wook

AU - Choi, Yang Il

AU - Kim, Kwan Suk

AU - Gotoh, Takafumi

AU - Lee, Jun Heon

PY - 2015/1/1

Y1 - 2015/1/1

N2 - The melanocortin-4 receptor (MC4R) gene is known to encode a membrane-bound receptor protein and is a member of the melanocortin receptor family of genes. In mammals, these genes are involved in energy homeostasis and in regulating feeding behavior and body weight. The objective of the present study was to examine if there were any associations between variations in the MC4R gene with meat quality traits in a commercial pig population in Korea. Among the total of 593 commercial pigs, sire information was retrieved from 232 pigs. These animals were successfully genotyped for the c.892A>G (p. Asp298Asn) single nucleotide polymorphism (SNP) by using ThqI PCR-RFLP methods. Association analyses between this SNP and meat quality traits were performed using a general linear model (GLM) including sire effect. This SNP was significantly associated with backfat thickness (P<0.05), marbling (P<0.01). Interestingly, this SNP marker was also associated with volatile basic nitrogen after 14 days of storage (P<0.05). To our knowledge, it is the first results observed for the MC4R genotypes with volatile basic nitrogen after 14 days of storage in the commercial pig population. Therefore, these results suggest that the MC4R gene can be targeted in marker-assisted breeding for selecting pigs with good meat quality.

AB - The melanocortin-4 receptor (MC4R) gene is known to encode a membrane-bound receptor protein and is a member of the melanocortin receptor family of genes. In mammals, these genes are involved in energy homeostasis and in regulating feeding behavior and body weight. The objective of the present study was to examine if there were any associations between variations in the MC4R gene with meat quality traits in a commercial pig population in Korea. Among the total of 593 commercial pigs, sire information was retrieved from 232 pigs. These animals were successfully genotyped for the c.892A>G (p. Asp298Asn) single nucleotide polymorphism (SNP) by using ThqI PCR-RFLP methods. Association analyses between this SNP and meat quality traits were performed using a general linear model (GLM) including sire effect. This SNP was significantly associated with backfat thickness (P<0.05), marbling (P<0.01). Interestingly, this SNP marker was also associated with volatile basic nitrogen after 14 days of storage (P<0.05). To our knowledge, it is the first results observed for the MC4R genotypes with volatile basic nitrogen after 14 days of storage in the commercial pig population. Therefore, these results suggest that the MC4R gene can be targeted in marker-assisted breeding for selecting pigs with good meat quality.

UR - http://www.scopus.com/inward/record.url?scp=84927758595&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84927758595&partnerID=8YFLogxK

M3 - Article

VL - 60

SP - 113

EP - 118

JO - Journal of the Faculty of Agriculture, Kyushu University

JF - Journal of the Faculty of Agriculture, Kyushu University

SN - 0023-6152

IS - 1

ER -