TY - JOUR
T1 - Association study of polymorphisms in the GluR5 kainate receptor gene (GRIK1) with schizophrenia
AU - Shibata, Hiroki
AU - Joo, Akiko
AU - Fujii, Yo
AU - Tani, Ayako
AU - Makino, Chieko
AU - Hirata, Naotsugu
AU - Kikuta, Rumiko
AU - Ninomiya, Hideaki
AU - Tashiro, Nobutada
AU - Fukumaki, Yasuyuki
PY - 2001
Y1 - 2001
N2 - The glutamatergic dysfunction hypothesis suggests genes involved in glutamatergic transmission as candidates for schizophrenia susceptibility genes. We screened single nucleotide polymorphisms (SNPs) in the entire coding sequence of the GluR5 kainate receptor gene, GRIK1, by polymerase chain reaction-single strand conformation polymorphism and direct sequencing. We identified six SNPs including three known ones, 522A/C (174T, synonymous), 1173C/T (391D, synonymous), and 2705C/T (902L/S), as well as three novel ones, 995C/T (332A/V), 2400C/T (800L, synonymous), and 2585A/G (862R/Q). We genotyped Japanese samples of schizophrenia (n = 193-203) and healthy controls (n = 199-215) for three SNPs those were commonly observed in our samples, 522A/C, 1173C/T, and 2705C/T. We observed no significant associations of the SNPs and their haplotypes with schizophrenia. Therefore, we conclude that GRIK1 does not play a major role in schizophrenia pathogenesis in the Japanese population.
AB - The glutamatergic dysfunction hypothesis suggests genes involved in glutamatergic transmission as candidates for schizophrenia susceptibility genes. We screened single nucleotide polymorphisms (SNPs) in the entire coding sequence of the GluR5 kainate receptor gene, GRIK1, by polymerase chain reaction-single strand conformation polymorphism and direct sequencing. We identified six SNPs including three known ones, 522A/C (174T, synonymous), 1173C/T (391D, synonymous), and 2705C/T (902L/S), as well as three novel ones, 995C/T (332A/V), 2400C/T (800L, synonymous), and 2585A/G (862R/Q). We genotyped Japanese samples of schizophrenia (n = 193-203) and healthy controls (n = 199-215) for three SNPs those were commonly observed in our samples, 522A/C, 1173C/T, and 2705C/T. We observed no significant associations of the SNPs and their haplotypes with schizophrenia. Therefore, we conclude that GRIK1 does not play a major role in schizophrenia pathogenesis in the Japanese population.
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U2 - 10.1097/00041444-200109000-00005
DO - 10.1097/00041444-200109000-00005
M3 - Article
C2 - 11702055
AN - SCOPUS:0034779896
SN - 0955-8829
VL - 11
SP - 139
EP - 144
JO - Psychiatric Genetics
JF - Psychiatric Genetics
IS - 3
ER -
