Association study of polymorphisms in the GluR6 kainate receptor gene (GRIK2) with schizophrenia

Hiroki Shibata, Atsushi Shibata, Hideaki Ninomiya, Nobutada Tashiro, Yasuyuki Fukumaki

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The glutamatergic dysfunction hypothesis of schizophrenia suggests genes involved in glutamatergic transmission as candidates for schizophrenia-susceptibility genes. The GluR6 kainate receptor gene GRIK2 is located on chromosome 6q16.3-q21, a schizophrenia susceptibility region, as suggested by multiple linkage studies. We examined 15 SNPs evenly distributed in the entire GRIK2 region (>700 kb) in Japanese patients with schizophrenia (n=100) and controls (n=100). Neither genotype nor allele frequency showed a significant association with the disorder. We constructed 2-SNP haplotypes from the 15 SNPs. Although we observed three long linkage disequilibrium blocks (>150 kb) within the GRIK2 region, none of the pairwise haplotypes showed a significant association with the disorder. Therefore, we conclude that GRIK2 does not play a major role in the pathogenesis of schizophrenia in the Japanese population.

Original languageEnglish
Pages (from-to)59-67
Number of pages9
JournalPsychiatry research
Volume113
Issue number1-2
DOIs
Publication statusPublished - Dec 15 2002

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Schizophrenia
Single Nucleotide Polymorphism
Genes
Haplotypes
Linkage Disequilibrium
Gene Frequency
Chromosomes
Genotype
Gluk2 kainate receptor
Population

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

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Association study of polymorphisms in the GluR6 kainate receptor gene (GRIK2) with schizophrenia. / Shibata, Hiroki; Shibata, Atsushi; Ninomiya, Hideaki; Tashiro, Nobutada; Fukumaki, Yasuyuki.

In: Psychiatry research, Vol. 113, No. 1-2, 15.12.2002, p. 59-67.

Research output: Contribution to journalArticle

Shibata, Hiroki ; Shibata, Atsushi ; Ninomiya, Hideaki ; Tashiro, Nobutada ; Fukumaki, Yasuyuki. / Association study of polymorphisms in the GluR6 kainate receptor gene (GRIK2) with schizophrenia. In: Psychiatry research. 2002 ; Vol. 113, No. 1-2. pp. 59-67.
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