Associations between driver gene mutations and cytotoxic chemosensitivity in patients with non-small cell lung cancer

Yosuke Morodomi, Tatsuro Okamoto, Mikihiro Kohno, Masakazu Katsura, Kazuki Takada, Yuzo Suzuki, Takatoshi Fujishita, Hirokazu Kitahara, Shinichiro Shimamatsu, Tsukihisa Yoshida, Tetsuzo Tagawa, Shinji Okano, Yoshihiko Maehara

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Abstract

Background/Aim: Patients with non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) gene mutations or echinoderm microtubuleassociated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) rearrangement often have a better prognosis when they are treated with specific inhibitors than when treated with cytotoxic agents. However, the associations between gene mutations and cytotoxic chemosensitivity are still unclear. The objective of the present study was to identify which clinicopathological factors, including genetic mutations, influence chemosensitivity, determined using the succinate dehydrogenase inhibition (SDI) test in patients with NSCLC. Materials and Methods: The chemosensitivity of tumor tissues from 96 patients with NSCLC who underwent surgical resection was evaluated using the SDI test. Results: In patients with adenocarcinoma, tumors with EGFR gene mutations were significantly more sensitive to 5-fluorouracil (5-FU) than tumors without EGFR gene mutations (p<0.0149). Conclusion: Our data suggest that patients with adenocarcinoma harboring EGFR gene mutations may be susceptible to 5-FU.

Original languageEnglish
Pages (from-to)1791-1796
Number of pages6
JournalAnticancer research
Volume35
Issue number3
Publication statusPublished - Mar 1 2015

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Morodomi, Y., Okamoto, T., Kohno, M., Katsura, M., Takada, K., Suzuki, Y., Fujishita, T., Kitahara, H., Shimamatsu, S., Yoshida, T., Tagawa, T., Okano, S., & Maehara, Y. (2015). Associations between driver gene mutations and cytotoxic chemosensitivity in patients with non-small cell lung cancer. Anticancer research, 35(3), 1791-1796.