Associations between renal impairment and anemia in older, rural Japanese men: The Nagasaki Island study

Yuji Shimizu, Shimpei Sato, Jun Koyamatsu, Hirotomo Yamanashi, Mako Nagayoshi, Koichiro Kadota, Mami Tamai, Kazuhiko Arima, Hironori Yamasaki, Yosuke Kusano, Noboru Takamura, Takahiro Maeda

Research output: Contribution to journalArticle

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Abstract

Background: Renal impairment is known to be associated with atherosclerosis, which in turn is reported to be positively associated with hemoglobin levels. In addition, renal impairment is known to be associated with a form of anemia known as renal anemia.Methods: To clarify the associations between renal impairment and anemia, we conducted a cross-sectional study of 1,105 60 to 89-year-old men, who were not taking medication for anemia and were undergoing general health check-ups.Results: Compared with non-chronic kidney disease, chronic kidney disease (CKD) with a glomerular filtration rate (GFR) <60 mL/min/1.73 m2 was found to constitute a significant risk of anemia. However, we noted that this risk was lower for mild renal impairment (60 mL/min/1.73 m2 ≤ GFR <90 mL/min/1.73 m2). Compared with the non-CKD reference group, the classical cardiovascular risk factors adjusted odds ratio (OR) for anemia was 1.81 (1.23 to 2.68) and compared with the normal renal function (GFR ≥90 mL/min/1.73 m2) reference group, the ORs for mild renal impairment and CKD were 0.26 (0.15 to 0.47) and 0.60 (0.33 to 1.09).Conclusions: Independent from classical cardiovascular risk factors, CKD, which was identified during general health check-ups, appeared to constitute a significant risk of anemia for older Japanese men. For mild renal impairment, however, this association was a reduced risk of anemia and thus possibly a higher risk of atherosclerosis.

Original languageEnglish
Article number7
JournalJournal of physiological anthropology
Volume33
Issue number1
DOIs
Publication statusPublished - Apr 17 2014

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Islands
Anemia
Kidney
Disease
Glomerular Filtration Rate
Chronic Renal Insufficiency
reference group
Kidney Diseases
Atherosclerosis
Health
Hemoglobin
health
cross-sectional study
medication
Hemoglobins
Cross-Sectional Studies
Odds Ratio

All Science Journal Classification (ASJC) codes

  • Human Factors and Ergonomics
  • Physiology
  • Orthopedics and Sports Medicine
  • Anthropology
  • Public Health, Environmental and Occupational Health
  • Physiology (medical)

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Associations between renal impairment and anemia in older, rural Japanese men : The Nagasaki Island study. / Shimizu, Yuji; Sato, Shimpei; Koyamatsu, Jun; Yamanashi, Hirotomo; Nagayoshi, Mako; Kadota, Koichiro; Tamai, Mami; Arima, Kazuhiko; Yamasaki, Hironori; Kusano, Yosuke; Takamura, Noboru; Maeda, Takahiro.

In: Journal of physiological anthropology, Vol. 33, No. 1, 7, 17.04.2014.

Research output: Contribution to journalArticle

Shimizu, Y, Sato, S, Koyamatsu, J, Yamanashi, H, Nagayoshi, M, Kadota, K, Tamai, M, Arima, K, Yamasaki, H, Kusano, Y, Takamura, N & Maeda, T 2014, 'Associations between renal impairment and anemia in older, rural Japanese men: The Nagasaki Island study', Journal of physiological anthropology, vol. 33, no. 1, 7. https://doi.org/10.1186/1880-6805-33-7
Shimizu, Yuji ; Sato, Shimpei ; Koyamatsu, Jun ; Yamanashi, Hirotomo ; Nagayoshi, Mako ; Kadota, Koichiro ; Tamai, Mami ; Arima, Kazuhiko ; Yamasaki, Hironori ; Kusano, Yosuke ; Takamura, Noboru ; Maeda, Takahiro. / Associations between renal impairment and anemia in older, rural Japanese men : The Nagasaki Island study. In: Journal of physiological anthropology. 2014 ; Vol. 33, No. 1.
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AU - Shimizu, Yuji

AU - Sato, Shimpei

AU - Koyamatsu, Jun

AU - Yamanashi, Hirotomo

AU - Nagayoshi, Mako

AU - Kadota, Koichiro

AU - Tamai, Mami

AU - Arima, Kazuhiko

AU - Yamasaki, Hironori

AU - Kusano, Yosuke

AU - Takamura, Noboru

AU - Maeda, Takahiro

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N2 - Background: Renal impairment is known to be associated with atherosclerosis, which in turn is reported to be positively associated with hemoglobin levels. In addition, renal impairment is known to be associated with a form of anemia known as renal anemia.Methods: To clarify the associations between renal impairment and anemia, we conducted a cross-sectional study of 1,105 60 to 89-year-old men, who were not taking medication for anemia and were undergoing general health check-ups.Results: Compared with non-chronic kidney disease, chronic kidney disease (CKD) with a glomerular filtration rate (GFR) <60 mL/min/1.73 m2 was found to constitute a significant risk of anemia. However, we noted that this risk was lower for mild renal impairment (60 mL/min/1.73 m2 ≤ GFR <90 mL/min/1.73 m2). Compared with the non-CKD reference group, the classical cardiovascular risk factors adjusted odds ratio (OR) for anemia was 1.81 (1.23 to 2.68) and compared with the normal renal function (GFR ≥90 mL/min/1.73 m2) reference group, the ORs for mild renal impairment and CKD were 0.26 (0.15 to 0.47) and 0.60 (0.33 to 1.09).Conclusions: Independent from classical cardiovascular risk factors, CKD, which was identified during general health check-ups, appeared to constitute a significant risk of anemia for older Japanese men. For mild renal impairment, however, this association was a reduced risk of anemia and thus possibly a higher risk of atherosclerosis.

AB - Background: Renal impairment is known to be associated with atherosclerosis, which in turn is reported to be positively associated with hemoglobin levels. In addition, renal impairment is known to be associated with a form of anemia known as renal anemia.Methods: To clarify the associations between renal impairment and anemia, we conducted a cross-sectional study of 1,105 60 to 89-year-old men, who were not taking medication for anemia and were undergoing general health check-ups.Results: Compared with non-chronic kidney disease, chronic kidney disease (CKD) with a glomerular filtration rate (GFR) <60 mL/min/1.73 m2 was found to constitute a significant risk of anemia. However, we noted that this risk was lower for mild renal impairment (60 mL/min/1.73 m2 ≤ GFR <90 mL/min/1.73 m2). Compared with the non-CKD reference group, the classical cardiovascular risk factors adjusted odds ratio (OR) for anemia was 1.81 (1.23 to 2.68) and compared with the normal renal function (GFR ≥90 mL/min/1.73 m2) reference group, the ORs for mild renal impairment and CKD were 0.26 (0.15 to 0.47) and 0.60 (0.33 to 1.09).Conclusions: Independent from classical cardiovascular risk factors, CKD, which was identified during general health check-ups, appeared to constitute a significant risk of anemia for older Japanese men. For mild renal impairment, however, this association was a reduced risk of anemia and thus possibly a higher risk of atherosclerosis.

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