Abstract
Background: Renal impairment is known to be associated with atherosclerosis, which in turn is reported to be positively associated with hemoglobin levels. In addition, renal impairment is known to be associated with a form of anemia known as renal anemia.Methods: To clarify the associations between renal impairment and anemia, we conducted a cross-sectional study of 1,105 60 to 89-year-old men, who were not taking medication for anemia and were undergoing general health check-ups.Results: Compared with non-chronic kidney disease, chronic kidney disease (CKD) with a glomerular filtration rate (GFR) <60 mL/min/1.73 m2 was found to constitute a significant risk of anemia. However, we noted that this risk was lower for mild renal impairment (60 mL/min/1.73 m2 ≤ GFR <90 mL/min/1.73 m2). Compared with the non-CKD reference group, the classical cardiovascular risk factors adjusted odds ratio (OR) for anemia was 1.81 (1.23 to 2.68) and compared with the normal renal function (GFR ≥90 mL/min/1.73 m2) reference group, the ORs for mild renal impairment and CKD were 0.26 (0.15 to 0.47) and 0.60 (0.33 to 1.09).Conclusions: Independent from classical cardiovascular risk factors, CKD, which was identified during general health check-ups, appeared to constitute a significant risk of anemia for older Japanese men. For mild renal impairment, however, this association was a reduced risk of anemia and thus possibly a higher risk of atherosclerosis.
| Original language | English |
|---|---|
| Article number | 7 |
| Journal | Journal of physiological anthropology |
| Volume | 33 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Apr 17 2014 |
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All Science Journal Classification (ASJC) codes
- Human Factors and Ergonomics
- Physiology
- Orthopedics and Sports Medicine
- Anthropology
- Public Health, Environmental and Occupational Health
- Physiology (medical)
Cite this
Associations between renal impairment and anemia in older, rural Japanese men : The Nagasaki Island study. / Shimizu, Yuji; Sato, Shimpei; Koyamatsu, Jun; Yamanashi, Hirotomo; Nagayoshi, Mako; Kadota, Koichiro; Tamai, Mami; Arima, Kazuhiko; Yamasaki, Hironori; Kusano, Yosuke; Takamura, Noboru; Maeda, Takahiro.
In: Journal of physiological anthropology, Vol. 33, No. 1, 7, 17.04.2014.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Associations between renal impairment and anemia in older, rural Japanese men
T2 - The Nagasaki Island study
AU - Shimizu, Yuji
AU - Sato, Shimpei
AU - Koyamatsu, Jun
AU - Yamanashi, Hirotomo
AU - Nagayoshi, Mako
AU - Kadota, Koichiro
AU - Tamai, Mami
AU - Arima, Kazuhiko
AU - Yamasaki, Hironori
AU - Kusano, Yosuke
AU - Takamura, Noboru
AU - Maeda, Takahiro
PY - 2014/4/17
Y1 - 2014/4/17
N2 - Background: Renal impairment is known to be associated with atherosclerosis, which in turn is reported to be positively associated with hemoglobin levels. In addition, renal impairment is known to be associated with a form of anemia known as renal anemia.Methods: To clarify the associations between renal impairment and anemia, we conducted a cross-sectional study of 1,105 60 to 89-year-old men, who were not taking medication for anemia and were undergoing general health check-ups.Results: Compared with non-chronic kidney disease, chronic kidney disease (CKD) with a glomerular filtration rate (GFR) <60 mL/min/1.73 m2 was found to constitute a significant risk of anemia. However, we noted that this risk was lower for mild renal impairment (60 mL/min/1.73 m2 ≤ GFR <90 mL/min/1.73 m2). Compared with the non-CKD reference group, the classical cardiovascular risk factors adjusted odds ratio (OR) for anemia was 1.81 (1.23 to 2.68) and compared with the normal renal function (GFR ≥90 mL/min/1.73 m2) reference group, the ORs for mild renal impairment and CKD were 0.26 (0.15 to 0.47) and 0.60 (0.33 to 1.09).Conclusions: Independent from classical cardiovascular risk factors, CKD, which was identified during general health check-ups, appeared to constitute a significant risk of anemia for older Japanese men. For mild renal impairment, however, this association was a reduced risk of anemia and thus possibly a higher risk of atherosclerosis.
AB - Background: Renal impairment is known to be associated with atherosclerosis, which in turn is reported to be positively associated with hemoglobin levels. In addition, renal impairment is known to be associated with a form of anemia known as renal anemia.Methods: To clarify the associations between renal impairment and anemia, we conducted a cross-sectional study of 1,105 60 to 89-year-old men, who were not taking medication for anemia and were undergoing general health check-ups.Results: Compared with non-chronic kidney disease, chronic kidney disease (CKD) with a glomerular filtration rate (GFR) <60 mL/min/1.73 m2 was found to constitute a significant risk of anemia. However, we noted that this risk was lower for mild renal impairment (60 mL/min/1.73 m2 ≤ GFR <90 mL/min/1.73 m2). Compared with the non-CKD reference group, the classical cardiovascular risk factors adjusted odds ratio (OR) for anemia was 1.81 (1.23 to 2.68) and compared with the normal renal function (GFR ≥90 mL/min/1.73 m2) reference group, the ORs for mild renal impairment and CKD were 0.26 (0.15 to 0.47) and 0.60 (0.33 to 1.09).Conclusions: Independent from classical cardiovascular risk factors, CKD, which was identified during general health check-ups, appeared to constitute a significant risk of anemia for older Japanese men. For mild renal impairment, however, this association was a reduced risk of anemia and thus possibly a higher risk of atherosclerosis.
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U2 - 10.1186/1880-6805-33-7
DO - 10.1186/1880-6805-33-7
M3 - Article
C2 - 24742197
AN - SCOPUS:84899951326
VL - 33
JO - Journal of Physiological Anthropology
JF - Journal of Physiological Anthropology
SN - 1880-6791
IS - 1
M1 - 7
ER -