Associations between serum uric acid levels and the incidence of nonfatal stroke: a nationwide community-based cohort study

Keita Kamei, Tsuneo Konta, Atsushi Hirayama, Kazunobu Ichikawa, Isao Kubota, Shouichi Fujimoto, Kunitoshi Iseki, Toshiki Moriyama, Kunihiro Yamagata, Kazuhiko Tsuruya, Ichiei Narita, Masahide Kondo, Yugo Shibagaki, Masato Kasahara, Koichi Asahi, Tsuyoshi Watanabe

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Hyperuricemia is an established risk factor for cardiovascular events and mortality. This study investigated the association between serum uric acid and the incidence of nonfatal stroke in a Japanese community-based population. Methods: We used a nationwide database of 155,322 subjects (aged 40–73, male 39 %) who participated in the annual “Specific Health Check and Guidance in Japan” checkup from 2008 to 2010. We examined the relationship between the quintiles of serum uric acid levels at baseline and the incidence of nonfatal stroke during a 2-year study period using self-reported data. Results: The crude incidence of nonfatal stroke was significantly associated with serum uric acid levels at baseline, showing the lowest values in subjects with the 3rd quintile (Q3: men, 5.0–5.6; women, 3.8–4.3) of uric acid levels (mg/dL) and the highest values in subjects with the highest quintile (Q5: men ≥7.1, women ≥5.5) both in men and women (P < 0.05). In multivariate-adjusted logistic regression analysis, the odds ratio (OR) of the Q5 group was significantly higher than for the Q3 group in both men and women [men: OR 1.26, 95 % confidence interval (CI) 1.04–1.54, women: OR 1.24, 95 % CI 1.00–1.48]. In the subgroup analysis, the OR of the Q5 group of uric acid levels for incident stroke was high, irrespective of characteristics such as age, sex, and renal function. Conclusions: This study has shown that serum uric acid is independently associated with the incidence of nonfatal stroke in the general Japanese population.

Original languageEnglish
Pages (from-to)497-503
Number of pages7
JournalClinical and Experimental Nephrology
Volume21
Issue number3
DOIs
Publication statusPublished - Jun 1 2017

Fingerprint

Uric Acid
Cohort Studies
Stroke
Incidence
Serum
Odds Ratio
Confidence Intervals
Hyperuricemia
Population
Japan
Logistic Models
Regression Analysis
Databases
Kidney
Mortality
Health

All Science Journal Classification (ASJC) codes

  • Physiology
  • Nephrology
  • Physiology (medical)

Cite this

Associations between serum uric acid levels and the incidence of nonfatal stroke : a nationwide community-based cohort study. / Kamei, Keita; Konta, Tsuneo; Hirayama, Atsushi; Ichikawa, Kazunobu; Kubota, Isao; Fujimoto, Shouichi; Iseki, Kunitoshi; Moriyama, Toshiki; Yamagata, Kunihiro; Tsuruya, Kazuhiko; Narita, Ichiei; Kondo, Masahide; Shibagaki, Yugo; Kasahara, Masato; Asahi, Koichi; Watanabe, Tsuyoshi.

In: Clinical and Experimental Nephrology, Vol. 21, No. 3, 01.06.2017, p. 497-503.

Research output: Contribution to journalArticle

Kamei, K, Konta, T, Hirayama, A, Ichikawa, K, Kubota, I, Fujimoto, S, Iseki, K, Moriyama, T, Yamagata, K, Tsuruya, K, Narita, I, Kondo, M, Shibagaki, Y, Kasahara, M, Asahi, K & Watanabe, T 2017, 'Associations between serum uric acid levels and the incidence of nonfatal stroke: a nationwide community-based cohort study', Clinical and Experimental Nephrology, vol. 21, no. 3, pp. 497-503. https://doi.org/10.1007/s10157-016-1311-7
Kamei, Keita ; Konta, Tsuneo ; Hirayama, Atsushi ; Ichikawa, Kazunobu ; Kubota, Isao ; Fujimoto, Shouichi ; Iseki, Kunitoshi ; Moriyama, Toshiki ; Yamagata, Kunihiro ; Tsuruya, Kazuhiko ; Narita, Ichiei ; Kondo, Masahide ; Shibagaki, Yugo ; Kasahara, Masato ; Asahi, Koichi ; Watanabe, Tsuyoshi. / Associations between serum uric acid levels and the incidence of nonfatal stroke : a nationwide community-based cohort study. In: Clinical and Experimental Nephrology. 2017 ; Vol. 21, No. 3. pp. 497-503.
@article{144482b235094f55b01bbec58525a7f1,
title = "Associations between serum uric acid levels and the incidence of nonfatal stroke: a nationwide community-based cohort study",
abstract = "Background: Hyperuricemia is an established risk factor for cardiovascular events and mortality. This study investigated the association between serum uric acid and the incidence of nonfatal stroke in a Japanese community-based population. Methods: We used a nationwide database of 155,322 subjects (aged 40–73, male 39 {\%}) who participated in the annual “Specific Health Check and Guidance in Japan” checkup from 2008 to 2010. We examined the relationship between the quintiles of serum uric acid levels at baseline and the incidence of nonfatal stroke during a 2-year study period using self-reported data. Results: The crude incidence of nonfatal stroke was significantly associated with serum uric acid levels at baseline, showing the lowest values in subjects with the 3rd quintile (Q3: men, 5.0–5.6; women, 3.8–4.3) of uric acid levels (mg/dL) and the highest values in subjects with the highest quintile (Q5: men ≥7.1, women ≥5.5) both in men and women (P < 0.05). In multivariate-adjusted logistic regression analysis, the odds ratio (OR) of the Q5 group was significantly higher than for the Q3 group in both men and women [men: OR 1.26, 95 {\%} confidence interval (CI) 1.04–1.54, women: OR 1.24, 95 {\%} CI 1.00–1.48]. In the subgroup analysis, the OR of the Q5 group of uric acid levels for incident stroke was high, irrespective of characteristics such as age, sex, and renal function. Conclusions: This study has shown that serum uric acid is independently associated with the incidence of nonfatal stroke in the general Japanese population.",
author = "Keita Kamei and Tsuneo Konta and Atsushi Hirayama and Kazunobu Ichikawa and Isao Kubota and Shouichi Fujimoto and Kunitoshi Iseki and Toshiki Moriyama and Kunihiro Yamagata and Kazuhiko Tsuruya and Ichiei Narita and Masahide Kondo and Yugo Shibagaki and Masato Kasahara and Koichi Asahi and Tsuyoshi Watanabe",
year = "2017",
month = "6",
day = "1",
doi = "10.1007/s10157-016-1311-7",
language = "English",
volume = "21",
pages = "497--503",
journal = "Clinical and Experimental Nephrology",
issn = "1342-1751",
publisher = "Springer Japan",
number = "3",

}

TY - JOUR

T1 - Associations between serum uric acid levels and the incidence of nonfatal stroke

T2 - a nationwide community-based cohort study

AU - Kamei, Keita

AU - Konta, Tsuneo

AU - Hirayama, Atsushi

AU - Ichikawa, Kazunobu

AU - Kubota, Isao

AU - Fujimoto, Shouichi

AU - Iseki, Kunitoshi

AU - Moriyama, Toshiki

AU - Yamagata, Kunihiro

AU - Tsuruya, Kazuhiko

AU - Narita, Ichiei

AU - Kondo, Masahide

AU - Shibagaki, Yugo

AU - Kasahara, Masato

AU - Asahi, Koichi

AU - Watanabe, Tsuyoshi

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Background: Hyperuricemia is an established risk factor for cardiovascular events and mortality. This study investigated the association between serum uric acid and the incidence of nonfatal stroke in a Japanese community-based population. Methods: We used a nationwide database of 155,322 subjects (aged 40–73, male 39 %) who participated in the annual “Specific Health Check and Guidance in Japan” checkup from 2008 to 2010. We examined the relationship between the quintiles of serum uric acid levels at baseline and the incidence of nonfatal stroke during a 2-year study period using self-reported data. Results: The crude incidence of nonfatal stroke was significantly associated with serum uric acid levels at baseline, showing the lowest values in subjects with the 3rd quintile (Q3: men, 5.0–5.6; women, 3.8–4.3) of uric acid levels (mg/dL) and the highest values in subjects with the highest quintile (Q5: men ≥7.1, women ≥5.5) both in men and women (P < 0.05). In multivariate-adjusted logistic regression analysis, the odds ratio (OR) of the Q5 group was significantly higher than for the Q3 group in both men and women [men: OR 1.26, 95 % confidence interval (CI) 1.04–1.54, women: OR 1.24, 95 % CI 1.00–1.48]. In the subgroup analysis, the OR of the Q5 group of uric acid levels for incident stroke was high, irrespective of characteristics such as age, sex, and renal function. Conclusions: This study has shown that serum uric acid is independently associated with the incidence of nonfatal stroke in the general Japanese population.

AB - Background: Hyperuricemia is an established risk factor for cardiovascular events and mortality. This study investigated the association between serum uric acid and the incidence of nonfatal stroke in a Japanese community-based population. Methods: We used a nationwide database of 155,322 subjects (aged 40–73, male 39 %) who participated in the annual “Specific Health Check and Guidance in Japan” checkup from 2008 to 2010. We examined the relationship between the quintiles of serum uric acid levels at baseline and the incidence of nonfatal stroke during a 2-year study period using self-reported data. Results: The crude incidence of nonfatal stroke was significantly associated with serum uric acid levels at baseline, showing the lowest values in subjects with the 3rd quintile (Q3: men, 5.0–5.6; women, 3.8–4.3) of uric acid levels (mg/dL) and the highest values in subjects with the highest quintile (Q5: men ≥7.1, women ≥5.5) both in men and women (P < 0.05). In multivariate-adjusted logistic regression analysis, the odds ratio (OR) of the Q5 group was significantly higher than for the Q3 group in both men and women [men: OR 1.26, 95 % confidence interval (CI) 1.04–1.54, women: OR 1.24, 95 % CI 1.00–1.48]. In the subgroup analysis, the OR of the Q5 group of uric acid levels for incident stroke was high, irrespective of characteristics such as age, sex, and renal function. Conclusions: This study has shown that serum uric acid is independently associated with the incidence of nonfatal stroke in the general Japanese population.

UR - http://www.scopus.com/inward/record.url?scp=84978140896&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84978140896&partnerID=8YFLogxK

U2 - 10.1007/s10157-016-1311-7

DO - 10.1007/s10157-016-1311-7

M3 - Article

AN - SCOPUS:84978140896

VL - 21

SP - 497

EP - 503

JO - Clinical and Experimental Nephrology

JF - Clinical and Experimental Nephrology

SN - 1342-1751

IS - 3

ER -