Associations of apolipoprotein A5 (APOA5), glucokinase (GCK) and glucokinase regulatory protein (GCKR) polymorphisms and lifestyle factors with the risk of dyslipidemia and dysglycemia in Japanese - A cross-sectional data from the J-MICC study

Asahi Hishida, Emi Morita, Mariko Naito, Rieko Okada, Kenji Wakai, Keitaro Matsuo, Kazuyo Nakamura, Naoyuki Takashima, Sadao Suzuki, Toshiro Takezaki, Haruo Mikami, Ohnaka Keizo, Yoshiyuki Watanabe, Hirokazu Uemura, Michiaki Kubo, Hideo Tanaka, Nobuyuki Hamajima

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

This study examined the associations of the APOA5 T-1131C (rs662799), G553T (Cys185Gly, rs2075291), GCK G-30A (rs1799884), GCKR A/G at intron 16 (rs780094) and T1403C (Leu446Pro, rs1260326) polymorphisms with serum lipid and glucose levels in Japanese, considering lifestyle factors. Study subjects were 2,191 participants (aged 35-69 years, 1,159 males) enrolled in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. Dyslipidemia was defined as fasting serum triglycerides (FTG) ≥ 150 mg/dL and/or HDL-cholesterol (HDL-C) < 40 mg/dL, while dysglycemia was as fasting blood sugar (FBS) ≥ 110 mg/dL. When those with APOA5 -1131 T/T or 553 G/G were defined as references, those with APOA5 -1131 T/C, C/C or 553 G/T, T/T demonstrated significantly elevated risk of dyslipidemia (age- and sex-adjusted odds ratio: 1.77 [95% confidence interval:1.39-2.27], 3.35 [2.41-4.65], 2.23 [1.64-3.02] and 13.78 [3.44-55.18], respectively). Evaluation of FTG, HDL-C or FBS levels according to the genotype revealed that FTG and HDL-C levels were significantly associated with the APOA5 T-1131C and G553T polymorphisms, FTG with the GCKR rs780094 and rs1260326 polymorphisms, and FBS with the GCKR rs780094 and rs1260326 polymorphisms. Moreover, a significant positive interaction between APOA5 553 G/T+T/T genotypes and fat intake ≥ 25% of total energy for the risk of dyslipidemia was observed. Our crosssectional study confirmed the essential roles of the polymorphisms of the APOA5, GCK and GCKR in the lipid or glucose metabolism disorders, and suggested the importance of fat intake control in the individualized prevention of dyslipidemia.

Original languageEnglish
Pages (from-to)589-599
Number of pages11
JournalEndocrine Journal
Volume59
Issue number7
DOIs
Publication statusPublished - Sep 6 2012

Fingerprint

Glucokinase
Apolipoproteins
Dyslipidemias
Life Style
Fasting
Japan
Cohort Studies
Triglycerides
HDL Cholesterol
Blood Glucose
Serum
Glucose Metabolism Disorders
Fats
Genotype
Lipid Metabolism Disorders
Staphylococcal Protein A
glucokinase regulatory protein
Introns
Apolipoprotein A-V
Odds Ratio

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Associations of apolipoprotein A5 (APOA5), glucokinase (GCK) and glucokinase regulatory protein (GCKR) polymorphisms and lifestyle factors with the risk of dyslipidemia and dysglycemia in Japanese - A cross-sectional data from the J-MICC study. / Hishida, Asahi; Morita, Emi; Naito, Mariko; Okada, Rieko; Wakai, Kenji; Matsuo, Keitaro; Nakamura, Kazuyo; Takashima, Naoyuki; Suzuki, Sadao; Takezaki, Toshiro; Mikami, Haruo; Keizo, Ohnaka; Watanabe, Yoshiyuki; Uemura, Hirokazu; Kubo, Michiaki; Tanaka, Hideo; Hamajima, Nobuyuki.

In: Endocrine Journal, Vol. 59, No. 7, 06.09.2012, p. 589-599.

Research output: Contribution to journalArticle

Hishida, A, Morita, E, Naito, M, Okada, R, Wakai, K, Matsuo, K, Nakamura, K, Takashima, N, Suzuki, S, Takezaki, T, Mikami, H, Keizo, O, Watanabe, Y, Uemura, H, Kubo, M, Tanaka, H & Hamajima, N 2012, 'Associations of apolipoprotein A5 (APOA5), glucokinase (GCK) and glucokinase regulatory protein (GCKR) polymorphisms and lifestyle factors with the risk of dyslipidemia and dysglycemia in Japanese - A cross-sectional data from the J-MICC study', Endocrine Journal, vol. 59, no. 7, pp. 589-599. https://doi.org/10.1507/endocrj.EJ11-0310
Hishida, Asahi ; Morita, Emi ; Naito, Mariko ; Okada, Rieko ; Wakai, Kenji ; Matsuo, Keitaro ; Nakamura, Kazuyo ; Takashima, Naoyuki ; Suzuki, Sadao ; Takezaki, Toshiro ; Mikami, Haruo ; Keizo, Ohnaka ; Watanabe, Yoshiyuki ; Uemura, Hirokazu ; Kubo, Michiaki ; Tanaka, Hideo ; Hamajima, Nobuyuki. / Associations of apolipoprotein A5 (APOA5), glucokinase (GCK) and glucokinase regulatory protein (GCKR) polymorphisms and lifestyle factors with the risk of dyslipidemia and dysglycemia in Japanese - A cross-sectional data from the J-MICC study. In: Endocrine Journal. 2012 ; Vol. 59, No. 7. pp. 589-599.
@article{75e6b9e2aaf8489caa91f8fd4d25881f,
title = "Associations of apolipoprotein A5 (APOA5), glucokinase (GCK) and glucokinase regulatory protein (GCKR) polymorphisms and lifestyle factors with the risk of dyslipidemia and dysglycemia in Japanese - A cross-sectional data from the J-MICC study",
abstract = "This study examined the associations of the APOA5 T-1131C (rs662799), G553T (Cys185Gly, rs2075291), GCK G-30A (rs1799884), GCKR A/G at intron 16 (rs780094) and T1403C (Leu446Pro, rs1260326) polymorphisms with serum lipid and glucose levels in Japanese, considering lifestyle factors. Study subjects were 2,191 participants (aged 35-69 years, 1,159 males) enrolled in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. Dyslipidemia was defined as fasting serum triglycerides (FTG) ≥ 150 mg/dL and/or HDL-cholesterol (HDL-C) < 40 mg/dL, while dysglycemia was as fasting blood sugar (FBS) ≥ 110 mg/dL. When those with APOA5 -1131 T/T or 553 G/G were defined as references, those with APOA5 -1131 T/C, C/C or 553 G/T, T/T demonstrated significantly elevated risk of dyslipidemia (age- and sex-adjusted odds ratio: 1.77 [95{\%} confidence interval:1.39-2.27], 3.35 [2.41-4.65], 2.23 [1.64-3.02] and 13.78 [3.44-55.18], respectively). Evaluation of FTG, HDL-C or FBS levels according to the genotype revealed that FTG and HDL-C levels were significantly associated with the APOA5 T-1131C and G553T polymorphisms, FTG with the GCKR rs780094 and rs1260326 polymorphisms, and FBS with the GCKR rs780094 and rs1260326 polymorphisms. Moreover, a significant positive interaction between APOA5 553 G/T+T/T genotypes and fat intake ≥ 25{\%} of total energy for the risk of dyslipidemia was observed. Our crosssectional study confirmed the essential roles of the polymorphisms of the APOA5, GCK and GCKR in the lipid or glucose metabolism disorders, and suggested the importance of fat intake control in the individualized prevention of dyslipidemia.",
author = "Asahi Hishida and Emi Morita and Mariko Naito and Rieko Okada and Kenji Wakai and Keitaro Matsuo and Kazuyo Nakamura and Naoyuki Takashima and Sadao Suzuki and Toshiro Takezaki and Haruo Mikami and Ohnaka Keizo and Yoshiyuki Watanabe and Hirokazu Uemura and Michiaki Kubo and Hideo Tanaka and Nobuyuki Hamajima",
year = "2012",
month = "9",
day = "6",
doi = "10.1507/endocrj.EJ11-0310",
language = "English",
volume = "59",
pages = "589--599",
journal = "Endocrine Journal",
issn = "0918-8959",
publisher = "Japan Endocrine Society",
number = "7",

}

TY - JOUR

T1 - Associations of apolipoprotein A5 (APOA5), glucokinase (GCK) and glucokinase regulatory protein (GCKR) polymorphisms and lifestyle factors with the risk of dyslipidemia and dysglycemia in Japanese - A cross-sectional data from the J-MICC study

AU - Hishida, Asahi

AU - Morita, Emi

AU - Naito, Mariko

AU - Okada, Rieko

AU - Wakai, Kenji

AU - Matsuo, Keitaro

AU - Nakamura, Kazuyo

AU - Takashima, Naoyuki

AU - Suzuki, Sadao

AU - Takezaki, Toshiro

AU - Mikami, Haruo

AU - Keizo, Ohnaka

AU - Watanabe, Yoshiyuki

AU - Uemura, Hirokazu

AU - Kubo, Michiaki

AU - Tanaka, Hideo

AU - Hamajima, Nobuyuki

PY - 2012/9/6

Y1 - 2012/9/6

N2 - This study examined the associations of the APOA5 T-1131C (rs662799), G553T (Cys185Gly, rs2075291), GCK G-30A (rs1799884), GCKR A/G at intron 16 (rs780094) and T1403C (Leu446Pro, rs1260326) polymorphisms with serum lipid and glucose levels in Japanese, considering lifestyle factors. Study subjects were 2,191 participants (aged 35-69 years, 1,159 males) enrolled in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. Dyslipidemia was defined as fasting serum triglycerides (FTG) ≥ 150 mg/dL and/or HDL-cholesterol (HDL-C) < 40 mg/dL, while dysglycemia was as fasting blood sugar (FBS) ≥ 110 mg/dL. When those with APOA5 -1131 T/T or 553 G/G were defined as references, those with APOA5 -1131 T/C, C/C or 553 G/T, T/T demonstrated significantly elevated risk of dyslipidemia (age- and sex-adjusted odds ratio: 1.77 [95% confidence interval:1.39-2.27], 3.35 [2.41-4.65], 2.23 [1.64-3.02] and 13.78 [3.44-55.18], respectively). Evaluation of FTG, HDL-C or FBS levels according to the genotype revealed that FTG and HDL-C levels were significantly associated with the APOA5 T-1131C and G553T polymorphisms, FTG with the GCKR rs780094 and rs1260326 polymorphisms, and FBS with the GCKR rs780094 and rs1260326 polymorphisms. Moreover, a significant positive interaction between APOA5 553 G/T+T/T genotypes and fat intake ≥ 25% of total energy for the risk of dyslipidemia was observed. Our crosssectional study confirmed the essential roles of the polymorphisms of the APOA5, GCK and GCKR in the lipid or glucose metabolism disorders, and suggested the importance of fat intake control in the individualized prevention of dyslipidemia.

AB - This study examined the associations of the APOA5 T-1131C (rs662799), G553T (Cys185Gly, rs2075291), GCK G-30A (rs1799884), GCKR A/G at intron 16 (rs780094) and T1403C (Leu446Pro, rs1260326) polymorphisms with serum lipid and glucose levels in Japanese, considering lifestyle factors. Study subjects were 2,191 participants (aged 35-69 years, 1,159 males) enrolled in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. Dyslipidemia was defined as fasting serum triglycerides (FTG) ≥ 150 mg/dL and/or HDL-cholesterol (HDL-C) < 40 mg/dL, while dysglycemia was as fasting blood sugar (FBS) ≥ 110 mg/dL. When those with APOA5 -1131 T/T or 553 G/G were defined as references, those with APOA5 -1131 T/C, C/C or 553 G/T, T/T demonstrated significantly elevated risk of dyslipidemia (age- and sex-adjusted odds ratio: 1.77 [95% confidence interval:1.39-2.27], 3.35 [2.41-4.65], 2.23 [1.64-3.02] and 13.78 [3.44-55.18], respectively). Evaluation of FTG, HDL-C or FBS levels according to the genotype revealed that FTG and HDL-C levels were significantly associated with the APOA5 T-1131C and G553T polymorphisms, FTG with the GCKR rs780094 and rs1260326 polymorphisms, and FBS with the GCKR rs780094 and rs1260326 polymorphisms. Moreover, a significant positive interaction between APOA5 553 G/T+T/T genotypes and fat intake ≥ 25% of total energy for the risk of dyslipidemia was observed. Our crosssectional study confirmed the essential roles of the polymorphisms of the APOA5, GCK and GCKR in the lipid or glucose metabolism disorders, and suggested the importance of fat intake control in the individualized prevention of dyslipidemia.

UR - http://www.scopus.com/inward/record.url?scp=84865646883&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865646883&partnerID=8YFLogxK

U2 - 10.1507/endocrj.EJ11-0310

DO - 10.1507/endocrj.EJ11-0310

M3 - Article

VL - 59

SP - 589

EP - 599

JO - Endocrine Journal

JF - Endocrine Journal

SN - 0918-8959

IS - 7

ER -