Associations of dog and cat ownership with wheezing and asthma in children: Pilot study of the Japan Environment and children’s study

Yu Taniguchi, Shin Yamazaki, Takehiro Michikawa, Shoji F. Nakayama, Makiko Sekiyama, Hiroshi Nitta, Hidetoshi Mezawa, Mayako Saito-Abe, Masako Oda, Hiroshi Mitsubuchi, Masafumi Sanefuji, Shouichi Ohga, Nathan Mise, Akihiko Ikegami, Masayuki Shimono, Reiko Suga

Research output: Contribution to journalArticle

Abstract

Objectives No previous study has used repeated measures data to examine the associations of dog/ cat ownership with wheezing and asthma prevalence among children. This prospective study used repeated measurers analysis to determine whether dog/cat ownership in childhood is an independent risk factor for wheezing and asthma, after adjustment for gestational, socio-economical, and demographical confounders confounders, in Japan. Methods We conducted a multicenter pilot study of the Japan Environment and Children’s Study (JECS) during 2009–2010. Among 440 newborn infants enrolled, 410 (52.8% males) were evaluated for dog/cat ownership in the home and history of wheezing and asthma in five follow-up questionnaire surveys (until age 6 years). Dog/cat ownership during follow-up period was categorized into four groups: 7.6% were long-term dog/cat owners, 5.9% were toddler-age owners, 5.9% were preschool-age owners, and 80.7% were never owners. Results The prevalence of wheezing during follow-up period increased from 20.8% to 35.4% and the prevalence of asthma increased from 1.3% to 16.3%. A fitted logistic generalized estimating equation models including important confounders showed no significant associations of the interaction between dog and/or cat ownership and follow-up time with the risks of wheezing and asthma. However, the risks of wheezing and asthma were slightly lower for long-term and toddler-age dog/cat owners than for preschool-age and never owners. Conclusions The present findings suggest that dog and cat ownership from toddler-age does not increase the risks of wheezing and asthma compared with never owners among Japanese children.

Original languageEnglish
Article numbere0232604
JournalPloS one
Volume15
Issue number5
DOIs
Publication statusPublished - May 2020

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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    Taniguchi, Y., Yamazaki, S., Michikawa, T., Nakayama, S. F., Sekiyama, M., Nitta, H., Mezawa, H., Saito-Abe, M., Oda, M., Mitsubuchi, H., Sanefuji, M., Ohga, S., Mise, N., Ikegami, A., Shimono, M., & Suga, R. (2020). Associations of dog and cat ownership with wheezing and asthma in children: Pilot study of the Japan Environment and children’s study. PloS one, 15(5), [e0232604]. https://doi.org/10.1371/journal.pone.0232604