Associations of HLA class i alleles in Japanese patients with Crohn's disease

D. Oryoji, T. Hisamatsu, K. Tsuchiya, J. Umeno, S. Ueda, K. Yamamoto, T. Matsumoto, M. Watanabe, T. Hibi, T. Sasazuki

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Abstract

Previous studies have suggested that the human leukocyte antigen (HLA) is involved in the etiology of Crohn's disease (CD); however, few reports are available on the association between HLA class I antigens and CD in Japan. In this study, we performed association analysis of HLA class I antigens in CD using 208 Japanese patients and 384 healthy controls. We identified novel positive associations between CD and HLA-A∗02:01 (odds ratio (OR)=1.64, P=0.016) and HLA-A∗02:07 (OR=2.31, P=0.0067) and confirmed previously reported positive associations between CD and HLA-Cw∗14:02 (OR=2.18, P=0.0021) and HLA-B∗51:01 (OR=1.70, P=0.033). We also identified novel negative associations between CD and HLA-A∗24:02 (OR=0.60, P=0.0047) and HLA-B∗07:02 (OR=0.38, P=0.0041). Although the associations were not significant after full Bonferroni correction, we suggested that HLA class I genes have dual functions, susceptibility and resistance in controlling the development of CD.

Original languageEnglish
Pages (from-to)54-56
Number of pages3
JournalGenes and Immunity
Volume16
Issue number1
DOIs
Publication statusPublished - Jan 24 2015

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All Science Journal Classification (ASJC) codes

  • Immunology
  • Genetics
  • Genetics(clinical)

Cite this

Oryoji, D., Hisamatsu, T., Tsuchiya, K., Umeno, J., Ueda, S., Yamamoto, K., ... Sasazuki, T. (2015). Associations of HLA class i alleles in Japanese patients with Crohn's disease. Genes and Immunity, 16(1), 54-56. https://doi.org/10.1038/gene.2014.61