TY - JOUR
T1 - Associations of HLA class i alleles in Japanese patients with Crohn's disease
AU - Oryoji, D.
AU - Hisamatsu, T.
AU - Tsuchiya, K.
AU - Umeno, J.
AU - Ueda, S.
AU - Yamamoto, K.
AU - Matsumoto, T.
AU - Watanabe, M.
AU - Hibi, T.
AU - Sasazuki, T.
N1 - Funding Information:
We thank all of the participants for providing blood samples. This work was supported by a Health Labour Sciences Research Grant for Research on Rare and Intractable Diseases from The Ministry of Health, Labour and Welfare, and by a Grant-in-Aid for Scientific Research on Innovative Areas, MEXT KAKENHI Grant Number 22133009, in Japan.
Publisher Copyright:
© 2015 Macmillan Publishers Limited.
Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 2015/1/24
Y1 - 2015/1/24
N2 - Previous studies have suggested that the human leukocyte antigen (HLA) is involved in the etiology of Crohn's disease (CD); however, few reports are available on the association between HLA class I antigens and CD in Japan. In this study, we performed association analysis of HLA class I antigens in CD using 208 Japanese patients and 384 healthy controls. We identified novel positive associations between CD and HLA-A∗02:01 (odds ratio (OR)=1.64, P=0.016) and HLA-A∗02:07 (OR=2.31, P=0.0067) and confirmed previously reported positive associations between CD and HLA-Cw∗14:02 (OR=2.18, P=0.0021) and HLA-B∗51:01 (OR=1.70, P=0.033). We also identified novel negative associations between CD and HLA-A∗24:02 (OR=0.60, P=0.0047) and HLA-B∗07:02 (OR=0.38, P=0.0041). Although the associations were not significant after full Bonferroni correction, we suggested that HLA class I genes have dual functions, susceptibility and resistance in controlling the development of CD.
AB - Previous studies have suggested that the human leukocyte antigen (HLA) is involved in the etiology of Crohn's disease (CD); however, few reports are available on the association between HLA class I antigens and CD in Japan. In this study, we performed association analysis of HLA class I antigens in CD using 208 Japanese patients and 384 healthy controls. We identified novel positive associations between CD and HLA-A∗02:01 (odds ratio (OR)=1.64, P=0.016) and HLA-A∗02:07 (OR=2.31, P=0.0067) and confirmed previously reported positive associations between CD and HLA-Cw∗14:02 (OR=2.18, P=0.0021) and HLA-B∗51:01 (OR=1.70, P=0.033). We also identified novel negative associations between CD and HLA-A∗24:02 (OR=0.60, P=0.0047) and HLA-B∗07:02 (OR=0.38, P=0.0041). Although the associations were not significant after full Bonferroni correction, we suggested that HLA class I genes have dual functions, susceptibility and resistance in controlling the development of CD.
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U2 - 10.1038/gene.2014.61
DO - 10.1038/gene.2014.61
M3 - Article
C2 - 25373727
AN - SCOPUS:84921598811
SN - 1466-4879
VL - 16
SP - 54
EP - 56
JO - Genes and Immunity
JF - Genes and Immunity
IS - 1
ER -
