Associations with health-related quality of life after intracerebral haemorrhage

Pooled analysis of INTERACT studies

Candice Delcourt, Danni Zheng, Xiaoying Chen, Maree Hackett, Hisatomi Arima, Jun Hata, Emma Heeley, Rustam Al-Shahi Salman, Mark Woodward, Yining Huang, Thompson Robinson, Pablo M. Lavados, Richard I. Lindley, Christian Stapf, Leo Davies, John Chalmers, Craig S. Anderson, Shoichiro Sato

Research output: Contribution to journalArticle

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Abstract

Background and purpose Limited data exist on health-related quality of life (HRQoL) after intracerebral haemorrhage (ICH). We aimed to determine baseline factors associated with HRQoL among participants of the pilot and main phases of the Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trials (INTERACT 1 and 2). Methods The INTERACT studies were randomised controlled trials of early intensive blood pressure (BP) lowering in patients with ICH (<6 hours) and elevated systolic BP (150-220 mm Hg). HRQoL was determined using the European Quality of Life Scale (EQ-5D) at 90 days, completed by patients or proxy responders. Binary logistic regression analyses were performed to identify factors associated with poor overall HRQoL. Results 2756 patients were included. Demographic, clinical and radiological factors associated with lower EQ-5D utility score were age, randomisation outside of China, antithrombotic use, high baseline National Institutes of Health Stroke Scale (NIHSS) score, larger ICH, presence of intraventricular extension and use of proxy responders. High (≥14) NIHSS score, larger ICH and proxy responders were associated with low scores in all five dimensions of the EQ-5D. The NIHSS score had a strong association with poor HRQoL (p<0.001). Female gender and antithrombotic use were associated with decreased scores in dimensions of pain/discomfort and usual activity, respectively. Conclusions Poor HRQoL was associated with age, comorbidities, proxy source of assessment, clinical severity and ICH characteristics. The strongest association was with initial clinical severity defined by high NIHSS score. Trial registration numbers NCT00226096 and NCT00716079; Post-results.

Original languageEnglish
Pages (from-to)70-75
Number of pages6
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume88
Issue number1
DOIs
Publication statusPublished - Jan 1 2017

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Cerebral Hemorrhage
Quality of Life
National Institutes of Health (U.S.)
Proxy
Stroke
Blood Pressure
Random Allocation
Comorbidity
China
Randomized Controlled Trials
Logistic Models
Regression Analysis
Demography
Pain

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology
  • Psychiatry and Mental health

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Associations with health-related quality of life after intracerebral haemorrhage : Pooled analysis of INTERACT studies. / Delcourt, Candice; Zheng, Danni; Chen, Xiaoying; Hackett, Maree; Arima, Hisatomi; Hata, Jun; Heeley, Emma; Al-Shahi Salman, Rustam; Woodward, Mark; Huang, Yining; Robinson, Thompson; Lavados, Pablo M.; Lindley, Richard I.; Stapf, Christian; Davies, Leo; Chalmers, John; Anderson, Craig S.; Sato, Shoichiro.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 88, No. 1, 01.01.2017, p. 70-75.

Research output: Contribution to journalArticle

Delcourt, C, Zheng, D, Chen, X, Hackett, M, Arima, H, Hata, J, Heeley, E, Al-Shahi Salman, R, Woodward, M, Huang, Y, Robinson, T, Lavados, PM, Lindley, RI, Stapf, C, Davies, L, Chalmers, J, Anderson, CS & Sato, S 2017, 'Associations with health-related quality of life after intracerebral haemorrhage: Pooled analysis of INTERACT studies', Journal of Neurology, Neurosurgery and Psychiatry, vol. 88, no. 1, pp. 70-75. https://doi.org/10.1136/jnnp-2016-314414
Delcourt, Candice ; Zheng, Danni ; Chen, Xiaoying ; Hackett, Maree ; Arima, Hisatomi ; Hata, Jun ; Heeley, Emma ; Al-Shahi Salman, Rustam ; Woodward, Mark ; Huang, Yining ; Robinson, Thompson ; Lavados, Pablo M. ; Lindley, Richard I. ; Stapf, Christian ; Davies, Leo ; Chalmers, John ; Anderson, Craig S. ; Sato, Shoichiro. / Associations with health-related quality of life after intracerebral haemorrhage : Pooled analysis of INTERACT studies. In: Journal of Neurology, Neurosurgery and Psychiatry. 2017 ; Vol. 88, No. 1. pp. 70-75.
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AU - Zheng, Danni

AU - Chen, Xiaoying

AU - Hackett, Maree

AU - Arima, Hisatomi

AU - Hata, Jun

AU - Heeley, Emma

AU - Al-Shahi Salman, Rustam

AU - Woodward, Mark

AU - Huang, Yining

AU - Robinson, Thompson

AU - Lavados, Pablo M.

AU - Lindley, Richard I.

AU - Stapf, Christian

AU - Davies, Leo

AU - Chalmers, John

AU - Anderson, Craig S.

AU - Sato, Shoichiro

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N2 - Background and purpose Limited data exist on health-related quality of life (HRQoL) after intracerebral haemorrhage (ICH). We aimed to determine baseline factors associated with HRQoL among participants of the pilot and main phases of the Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trials (INTERACT 1 and 2). Methods The INTERACT studies were randomised controlled trials of early intensive blood pressure (BP) lowering in patients with ICH (<6 hours) and elevated systolic BP (150-220 mm Hg). HRQoL was determined using the European Quality of Life Scale (EQ-5D) at 90 days, completed by patients or proxy responders. Binary logistic regression analyses were performed to identify factors associated with poor overall HRQoL. Results 2756 patients were included. Demographic, clinical and radiological factors associated with lower EQ-5D utility score were age, randomisation outside of China, antithrombotic use, high baseline National Institutes of Health Stroke Scale (NIHSS) score, larger ICH, presence of intraventricular extension and use of proxy responders. High (≥14) NIHSS score, larger ICH and proxy responders were associated with low scores in all five dimensions of the EQ-5D. The NIHSS score had a strong association with poor HRQoL (p<0.001). Female gender and antithrombotic use were associated with decreased scores in dimensions of pain/discomfort and usual activity, respectively. Conclusions Poor HRQoL was associated with age, comorbidities, proxy source of assessment, clinical severity and ICH characteristics. The strongest association was with initial clinical severity defined by high NIHSS score. Trial registration numbers NCT00226096 and NCT00716079; Post-results.

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