Astrocytes in the spinal dorsal horn and chronic itch

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Chronic itch is a hallmark symptom of inflammatory skin conditions, such as atopic dermatitis. Existing treatment for chronic itch is largely ineffective. Despite recent progress in our understanding of the neuronal basis for itch sensation in the peripheral and central nervous systems, the mechanisms underlying how itch turns into a pathological chronic state remain poorly understood. Recent studies have uncovered the causal role of astrocytes in the spinal dorsal horn using mouse models of chronic itch, including atopic dermatitis. Understanding the key roles of astrocytes may provide us with exciting insights into the mechanisms for the chronicity of itch sensation and clues to develop novel therapeutic agents for treating chronic itch.

Original languageEnglish
Pages (from-to)9-14
Number of pages6
JournalNeuroscience Research
Volume126
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

Atopic Dermatitis
Astrocytes
Peripheral Nervous System
Central Nervous System
Skin
Therapeutics
Spinal Cord Dorsal Horn

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Astrocytes in the spinal dorsal horn and chronic itch. / Makoto, Tsuda.

In: Neuroscience Research, Vol. 126, 01.01.2018, p. 9-14.

Research output: Contribution to journalReview article

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