Astrocytic Ca2+ responses in the spinal dorsal horn by noxious stimuli to the skin

Kohei Yoshihara, Tsuyoshi Matsuda, Yuta Koro, Hidetoshi Saitoh, Kazuhide Inoue, Tsuda Makoto

Research output: Contribution to journal › Article

3 Citations (Scopus)

Abstract

The role of astrocytes in the spinal dorsal horn (SDH) for sensory information processing under normal conditions is poorly understood. In this study, we investigated whether SDH astrocytes respond to noxious and innocuous stimuli to the skin of normal mice using in vivo two-photon Ca2+ imaging under anesthesia. We found that noxious stimulation evoked by intraplantar formalin injection provoked an elevation in intracellular Ca2+ levels in SDH astrocytes. By contrast, neither instantaneous noxious pinching nor innocuous stimuli (cooling or brushing) to the hindpaw elicited astrocytic Ca2+ responses. Thus, SDH astrocytes could respond preferentially to a strong and/or sustained noxious stimulus.

Original languageEnglish
Pages (from-to)101-104
Number of pages4
JournalJournal of Pharmacological Sciences
Volume137
Issue number1
DOIs
Publication statusPublished - May 1 2018

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Astrocytes
Skin
Automatic Data Processing
Photons
Formaldehyde
Anesthesia
Injections
Spinal Cord Dorsal Horn

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

Cite this

Astrocytic Ca2+ responses in the spinal dorsal horn by noxious stimuli to the skin. / Yoshihara, Kohei; Matsuda, Tsuyoshi; Koro, Yuta; Saitoh, Hidetoshi; Inoue, Kazuhide; Makoto, Tsuda.

In: Journal of Pharmacological Sciences, Vol. 137, No. 1, 01.05.2018, p. 101-104.

Research output: Contribution to journal › Article

Yoshihara, K, Matsuda, T, Koro, Y, Saitoh, H, Inoue, K & Makoto, T 2018, 'Astrocytic Ca2+ responses in the spinal dorsal horn by noxious stimuli to the skin', Journal of Pharmacological Sciences, vol. 137, no. 1, pp. 101-104. https://doi.org/10.1016/j.jphs.2018.04.007
Yoshihara K, Matsuda T, Koro Y, Saitoh H, Inoue K, Makoto T. Astrocytic Ca2+ responses in the spinal dorsal horn by noxious stimuli to the skin. Journal of Pharmacological Sciences. 2018 May 1;137(1):101-104. https://doi.org/10.1016/j.jphs.2018.04.007
Yoshihara, Kohei ; Matsuda, Tsuyoshi ; Koro, Yuta ; Saitoh, Hidetoshi ; Inoue, Kazuhide ; Makoto, Tsuda. / Astrocytic Ca2+ responses in the spinal dorsal horn by noxious stimuli to the skin. In: Journal of Pharmacological Sciences. 2018 ; Vol. 137, No. 1. pp. 101-104.
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