Asymmetric α-arylation of amino acid derivatives by clayden rearrangement of ester enolates via memory of chirality

Keisuke Tomohara, Tomoyuki Yoshimura, Ryuichi Hyakutake, Pan Yang, Takeo Kawabata

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

A method for asymmetric α-arylation of amino acid derivatives has been developed. The arylation was performed by Clayden rearrangement of ester enolates via memory of chirality to give hydantoins with an aryl-substituted tetrasubstituted carbon with up to 99% ee.

Original languageEnglish
Pages (from-to)13294-13297
Number of pages4
JournalJournal of the American Chemical Society
Volume135
Issue number36
DOIs
Publication statusPublished - Sep 11 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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