Abstract
A method for asymmetric α-arylation of amino acid derivatives has been developed. The arylation was performed by Clayden rearrangement of ester enolates via memory of chirality to give hydantoins with an aryl-substituted tetrasubstituted carbon with up to 99% ee.
| Original language | English |
|---|---|
| Pages (from-to) | 13294-13297 |
| Number of pages | 4 |
| Journal | Journal of the American Chemical Society |
| Volume | 135 |
| Issue number | 36 |
| DOIs | |
| Publication status | Published - Sep 11 2013 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Catalysis
- Chemistry(all)
- Biochemistry
- Colloid and Surface Chemistry
Cite this
Asymmetric α-arylation of amino acid derivatives by clayden rearrangement of ester enolates via memory of chirality. / Tomohara, Keisuke; Yoshimura, Tomoyuki; Hyakutake, Ryuichi; Yang, Pan; Kawabata, Takeo.
In: Journal of the American Chemical Society, Vol. 135, No. 36, 11.09.2013, p. 13294-13297.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Asymmetric α-arylation of amino acid derivatives by clayden rearrangement of ester enolates via memory of chirality
AU - Tomohara, Keisuke
AU - Yoshimura, Tomoyuki
AU - Hyakutake, Ryuichi
AU - Yang, Pan
AU - Kawabata, Takeo
PY - 2013/9/11
Y1 - 2013/9/11
N2 - A method for asymmetric α-arylation of amino acid derivatives has been developed. The arylation was performed by Clayden rearrangement of ester enolates via memory of chirality to give hydantoins with an aryl-substituted tetrasubstituted carbon with up to 99% ee.
AB - A method for asymmetric α-arylation of amino acid derivatives has been developed. The arylation was performed by Clayden rearrangement of ester enolates via memory of chirality to give hydantoins with an aryl-substituted tetrasubstituted carbon with up to 99% ee.
UR - http://www.scopus.com/inward/record.url?scp=84884178706&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84884178706&partnerID=8YFLogxK
U2 - 10.1021/ja406653n
DO - 10.1021/ja406653n
M3 - Article
VL - 135
SP - 13294
EP - 13297
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
SN - 0002-7863
IS - 36
ER -