Asymmetric 1,2-addition of organolithiums to aldimines catalyzed by chiral ligand

Isao Inoue, Mitsuru Shindo, Kenji Koga, Kiyoshi Tomioka

Research output: Contribution to journalArticlepeer-review

87 Citations (Scopus)

Abstract

An asymmetric 1,2-addition reaction of organolithiums with imines 3, 7 was catalysed by a 0.05-1.3 equivalent of a chiral amino ether 2 to provide the corresponding optically active amines 4, 8.

Original languageEnglish
Pages (from-to)4429-4438
Number of pages10
JournalTetrahedron
Volume50
Issue number15
DOIs
Publication statusPublished - Apr 11 1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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