TY - JOUR
T1 - Asymmetric alkylation of carboxyamides by using trans-2,5-disubstituted pyrrolidines as chiral auxiliaries
AU - Kawanami, Yasuhiro
AU - Ito, Yoshio
AU - Kitagawa, Toshiyuki
AU - Taniguchi, Yoshiyuki
AU - Katsuki, Tsutomu
AU - Yamaguchi, Masaru
PY - 1984
Y1 - 1984
N2 - trans-2,5-Bis(methoxymethyl)- and trans-2,5-bis(methoxymethoxymethyl)pyrrolidines proved to be excellent chiral auxiliaries for the asymmetric alkylation of the corresponding carboxyamide enolates giving good chemical yield and high stereoselectivity (invariably over 95% de), with remarkable flexibility to substrates and reaction conditions.
AB - trans-2,5-Bis(methoxymethyl)- and trans-2,5-bis(methoxymethoxymethyl)pyrrolidines proved to be excellent chiral auxiliaries for the asymmetric alkylation of the corresponding carboxyamide enolates giving good chemical yield and high stereoselectivity (invariably over 95% de), with remarkable flexibility to substrates and reaction conditions.
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U2 - 10.1016/S0040-4039(01)80046-0
DO - 10.1016/S0040-4039(01)80046-0
M3 - Article
AN - SCOPUS:0000176388
VL - 25
SP - 857
EP - 860
JO - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
IS - 8
ER -