Asymmetric alkynylation of aldehydes catalyzed by an In(III)/BINOL complex

Ryo Takita, Kenichiro Yakura, Takashi Ohshima, Masakatsu Shibasaki

Research output: Contribution to journalArticle

207 Citations (Scopus)

Abstract

Asymmetric alkynylation of both aromatic and aliphatic aldehydes using catalytic amounts of In(III)/BINOL is described. Dual activation of both substrates due to the "bifunctional character" of the indium(III) catalyst enables a broad range of substrate generality with high enantioselectivity (83 to > 99% ee).

Original languageEnglish
Pages (from-to)13760-13761
Number of pages2
JournalJournal of the American Chemical Society
Volume127
Issue number40
DOIs
Publication statusPublished - Oct 12 2005
Externally publishedYes

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Indium
Aldehydes
Enantioselectivity
Substrates
Chemical activation
Catalysts
naphthol BINOL

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

Asymmetric alkynylation of aldehydes catalyzed by an In(III)/BINOL complex. / Takita, Ryo; Yakura, Kenichiro; Ohshima, Takashi; Shibasaki, Masakatsu.

In: Journal of the American Chemical Society, Vol. 127, No. 40, 12.10.2005, p. 13760-13761.

Research output: Contribution to journalArticle

Takita, Ryo ; Yakura, Kenichiro ; Ohshima, Takashi ; Shibasaki, Masakatsu. / Asymmetric alkynylation of aldehydes catalyzed by an In(III)/BINOL complex. In: Journal of the American Chemical Society. 2005 ; Vol. 127, No. 40. pp. 13760-13761.
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