Asymmetric alkynylation of aldehydes catalyzed by an In(III)/BINOL complex

Ryo Takita, Kenichiro Yakura, Takashi Ohshima, Masakatsu Shibasaki

Research output: Contribution to journalArticlepeer-review

214 Citations (Scopus)

Abstract

Asymmetric alkynylation of both aromatic and aliphatic aldehydes using catalytic amounts of In(III)/BINOL is described. Dual activation of both substrates due to the "bifunctional character" of the indium(III) catalyst enables a broad range of substrate generality with high enantioselectivity (83 to > 99% ee).

Original languageEnglish
Pages (from-to)13760-13761
Number of pages2
JournalJournal of the American Chemical Society
Volume127
Issue number40
DOIs
Publication statusPublished - Oct 12 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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