Asymmetric construction of binaphthyl by the chiral diether-mediated conjugate addition of naphthyllithium to naphthalenecarboxylic acid 2,6-di-t-butyl-4-methoxyphenyl ester

Mitsuru Shindo, Yasutomo Yamamoto, Ken Ichi Yamada, Kiyoshi Tomioka

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Two ways for the synthesis of binaphthyl were examined based on a chiral ligand-mediated asymmetric conjugate addition of 1-naphthyllithium to naththalene-2-carboxylic acid 2,6-di-t-butyl-4-methoxyphenyl esters. The one pot method by conjugate addition-elimination gave a relatively higher enantioselectivity than the two step synthesis based on addition and subsequent oxidative aromatization.

Original languageEnglish
Pages (from-to)752-754
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume57
Issue number7
DOIs
Publication statusPublished - Jul 1 2009

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

Fingerprint Dive into the research topics of 'Asymmetric construction of binaphthyl by the chiral diether-mediated conjugate addition of naphthyllithium to naphthalenecarboxylic acid 2,6-di-t-butyl-4-methoxyphenyl ester'. Together they form a unique fingerprint.

  • Cite this