Asymmetric dihydroxylation of chiral olefins. High control of diastereofacial selection

Tohru Oishi, Kyo ichiro Iida, Masahiro Hirama

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

Highly diastereoselective dihydroxylation of 4,5-dihydroxy-2-pentenoate with osmium tetroxide using chiral N,N'-dialkyl-2,2′-bipyrrolidine ligands (1) is described. Either syn or anti selection was achieved for acetate (2d) and methyl ether (2e) by employing the enantiomeric ligands.

Original languageEnglish
Pages (from-to)3573-3576
Number of pages4
JournalTetrahedron Letters
Volume34
Issue number22
DOIs
Publication statusPublished - May 28 1993
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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