Highly diastereoselective dihydroxylation of 4,5-dihydroxy-2-pentenoate with osmium tetroxide using chiral N,N'-dialkyl-2,2′-bipyrrolidine ligands (1) is described. Either syn or anti selection was achieved for acetate (2d) and methyl ether (2e) by employing the enantiomeric ligands.
|Number of pages||4|
|Publication status||Published - May 28 1993|
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry