Asymmetric Hydrogenation of Azaindoles: Chemo- and Enantioselective Reduction of Fused Aromatic Ring Systems Consisting of Two Heteroarenes

Yusuke Makida, Masahiro Saita, Takahiro Kuramoto, Kentaro Ishizuka, Ryoichi Kuwano

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

High enantioselectivity was achieved for the hydrogenation of azaindoles by using the chiral catalyst, which was prepared from [Ru(η3-methallyl)2(cod)] and a trans-chelating bis(phosphine) ligand (PhTRAP). The dearomative reaction exclusively occurred on the five-membered ring, thus giving the corresponding azaindolines with up to 97:3 enantiomer ratio.

Original languageEnglish
Pages (from-to)11859-11862
Number of pages4
JournalAngewandte Chemie - International Edition
Volume55
Issue number39
DOIs
Publication statusPublished - Jan 1 2016

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phosphine
Enantiomers
Enantioselectivity
Chelation
Hydrogenation
Ligands
Catalysts

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

Cite this

Asymmetric Hydrogenation of Azaindoles : Chemo- and Enantioselective Reduction of Fused Aromatic Ring Systems Consisting of Two Heteroarenes. / Makida, Yusuke; Saita, Masahiro; Kuramoto, Takahiro; Ishizuka, Kentaro; Kuwano, Ryoichi.

In: Angewandte Chemie - International Edition, Vol. 55, No. 39, 01.01.2016, p. 11859-11862.

Research output: Contribution to journalArticle

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