Asymmetric Lewis acid catalysis of aluminum(salalen) complexes: Friedel-Crafts reaction of indole

Keitaro Suyama; Kazuhiro Matsumoto; Tsutomu Katsuki

doi:10.3987/COM-08-S(F)93

Asymmetric Lewis acid catalysis of aluminum(salalen) complexes: Friedel-Crafts reaction of indole

Keitaro Suyama, Kazuhiro Matsumoto, Tsutomu Katsuki

Division for Experimental Natural Science

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

We examined the Lewis acid catalysis of chiral Al(salalen)X complexes and found that complex 1b (X = Br) serves as an efficient catalyst for the Friedel-Crafts reaction of indole with N-[(E)-alkenoyl]oxazolidin-2-ones. High enantioselectivity (up to 98% ee) was obtained under the optimized conditions.

Original language	English
Pages (from-to)	817-824
Number of pages	8
Journal	Heterocycles
Volume	77
Issue number	2
DOIs	https://doi.org/10.3987/COM-08-S(F)93
Publication status	Published - Feb 1 2009

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Pharmacology
Organic Chemistry

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abstract = "We examined the Lewis acid catalysis of chiral Al(salalen)X complexes and found that complex 1b (X = Br) serves as an efficient catalyst for the Friedel-Crafts reaction of indole with N-[(E)-alkenoyl]oxazolidin-2-ones. High enantioselectivity (up to 98% ee) was obtained under the optimized conditions.",

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AB - We examined the Lewis acid catalysis of chiral Al(salalen)X complexes and found that complex 1b (X = Br) serves as an efficient catalyst for the Friedel-Crafts reaction of indole with N-[(E)-alkenoyl]oxazolidin-2-ones. High enantioselectivity (up to 98% ee) was obtained under the optimized conditions.

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Asymmetric Lewis acid catalysis of aluminum(salalen) complexes: Friedel-Crafts reaction of indole

Abstract

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