Asymmetric Lewis acid catalysis of aluminum(salalen) complexes: Friedel-Crafts reaction of indole

Keitaro Suyama, Kazuhiro Matsumoto, Tsutomu Katsuki

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

We examined the Lewis acid catalysis of chiral Al(salalen)X complexes and found that complex 1b (X = Br) serves as an efficient catalyst for the Friedel-Crafts reaction of indole with N-[(E)-alkenoyl]oxazolidin-2-ones. High enantioselectivity (up to 98% ee) was obtained under the optimized conditions.

Original languageEnglish
Pages (from-to)817-824
Number of pages8
JournalHeterocycles
Volume77
Issue number2
DOIs
Publication statusPublished - Feb 1 2009

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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