Asymmetric organolithium additions to imines

Kiyoshi Tomioka, Isao Inoue, Mitsuru Shindo, Kenji Koga

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

The reaction of methyllithium with 4-methoxyphenylimine of 1-naphthalenecarbaldehyde (1) in the presence of the chiral ligand A afforded, contrary to 1,4-addition with the cyclohexylimine, the corresponding 1,2-addition product as an optically active amine (2) in 70% ee.

Original languageEnglish
Pages (from-to)6681-6684
Number of pages4
JournalTetrahedron Letters
Volume31
Issue number46
DOIs
Publication statusPublished - 1990

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this