Asymmetric Reduction of α-Methyl β-Keto Esters by Microbial Cells Immobilized with Prepolymer

Hiroyuki Akita, Hiroko Matsukura, Takeshi Oishi, Atsuo Tanaka, Kenji Sonomoto

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6 Citations (Scopus)


Asymmetric reduction of a-methyl β-keto esters using microbial cells immobilized by the prepolymer method was examined. It was found that by a proper selection of the prepolymer in the stage of immobilization, the chemical and optical yields were both improved appreciably in some cases compared to those obtained by reduction with the native microorganisms.

Original languageEnglish
Pages (from-to)4985-4987
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Issue number12
Publication statusPublished - Jan 1 1987


All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

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