Asymmetric synthesis of α-amino β-hydroxy phosphonic acids via BINAP-ruthenium catalyzed hydrogenation

Masato Kitamura, Makoto Tokunaga, Trang Pham, William D. Lubell, Ryoji Noyori

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

BINAP-Ru catalyzed hydrogenation of configurationally labile α-amido β-keto phosphonic esters gives the (R,R)- or (S,S)-α-amido β-hydroxy phosphonic esters in a highly enantio- and diastereoselective manner.

Original languageEnglish
Pages (from-to)5769-5772
Number of pages4
JournalTetrahedron Letters
Volume36
Issue number32
DOIs
Publication statusPublished - Aug 7 1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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