Asymmetric synthesis of multisubstituted dihydrobenzofurans by intramolecular conjugate addition of short-lived C-O axially chiral enolates

Keisuke Tomohara, Koji Kasamatsu, Tomoyuki Yoshimura, Takumi Furuta, Takeo Kawabata

Research output: Contribution to journalArticle

6 Citations (Scopus)


Enantioselective intramolecular conjugate addition reactions of short-lived C-O axially chiral enolates have been developed. The reactions proceeded with inversion of the configuration and provided dihydrobenzofurans with contiguous tetra- and trisubstituted carbon centers in up to 96% enantiomeric excess (ee).

Original languageEnglish
Pages (from-to)899-906
Number of pages8
JournalChemical and Pharmaceutical Bulletin
Issue number7
Publication statusPublished - Jan 1 2016
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

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