Asymmetrical allocation of NMDA receptor ε2 subunits in hippocampal circuitry

Ryosuke Kawakami, Yoshiaki Shinohara, Yuichiro Kato, Hiroyuki Sugiyama, Ryuichi Shigemoto, Isao Ito

Research output: Contribution to journalArticle

150 Citations (Scopus)

Abstract

Despite its implications for higher order functions of the brain, little is currently known about the molecular basis of left-right asymmetry of the brain. Here we report that synaptic distribution of N-methyl-D-aspartate (NMDA) receptor GluRε2 (NR2B) subunits in the adult mouse hippocampus is asymmetrical between the left and right and between the apical and basal dendrites of single neurons. These asymmetrical allocations of ε2 subunits differentiate the properties of NMDA receptors and synaptic plasticity between the left and right hippocampus. These results provide a molecular basis for the structural and functional asymmetry of the mature brain.

Original languageEnglish
Pages (from-to)990-994
Number of pages5
JournalScience
Volume300
Issue number5621
DOIs
Publication statusPublished - May 9 2003

All Science Journal Classification (ASJC) codes

  • General

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    Kawakami, R., Shinohara, Y., Kato, Y., Sugiyama, H., Shigemoto, R., & Ito, I. (2003). Asymmetrical allocation of NMDA receptor ε2 subunits in hippocampal circuitry. Science, 300(5621), 990-994. https://doi.org/10.1126/science.1082609